Bioengineer

JANUARY 16, 2024

Often, the loss of T790M is associated with the development of alternative competitive resistance mechanisms. In patients with T790M mutant NSCLC receiving osimertinib, 63% experienced loss of T790M at progression, commonly linked to histological transdifferentiation, KRAS mutations, or gene fusions. months vs. 15.2 months, p = 0.01).

Genome 119

Genome Genomics Protein In-Vitro 119

Drug Discovery World

FEBRUARY 9, 2024

DDW recently hosted a webinar ‘Discover how iPSC derived cells can be used to support the development of drug and gene therapies’, supported by DefiniGEN. Chris explained that DefiniGEN is a liver cell company focussed on hepatocytes, particularly supporting the drug development industry in producing liver therapies.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

Drug Discovery World

SEPTEMBER 19, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype.

Gene Therapy 52

Gene Therapy Gene Development Protein 52

Drug Discovery World

SEPTEMBER 12, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. Register for free here.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

The Pharma Data

DECEMBER 9, 2020

The Chinese biopharmaceutical industry is growing in leaps and bounds, but there is still a huge unmet need when it comes to getting patients access to the breakthrough therapeutic modalities and platforms like RNAi, cell and gene therapy and others. A solution could be at hand with Overland Pharmaceuticals.

In-Vivo 52

In-Vivo In-Vitro Antibody Development 52

Drug Discovery World

AUGUST 25, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality. Also, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. However, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period.

Gene Therapy 52

Gene Therapy Gene Development Genotype 52

Drug Discovery World

SEPTEMBER 5, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype.

Development 59

Development Drugs Protein Genotype 59