ESMO 2022 – PAOLA-1, ovarian cancer, and treatment innovation
pharmaphorum
OCTOBER 27, 2022
It can be caused by different types of mutation, including within the BRCA gene and other forms of altered gene expression. HRD impairs cells’ ability to repair structural DNA breaks, leading to additional changes in the DNA of the tumour (known as genomic instability), and how that tumour will respond to certain treatments.
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