Bioengineer

JANUARY 16, 2024

This mutation hinders the drug’s binding to the mutant EGFR protein. Osimertinib, however, can covalently bind to the T790M and cysteine-797 (C797) residue at the protein’s ATP binding site, overcoming resistance mechanisms. In the same study, those with T790M loss had a shorter treatment duration (6.1 months vs. 15.2

Genome 119

Genome Genomics Protein In-Vitro 119

Drug Discovery World

FEBRUARY 9, 2024

DDW recently hosted a webinar ‘Discover how iPSC derived cells can be used to support the development of drug and gene therapies’, supported by DefiniGEN. However, hepatoma lines may lack the key proteins essential for modelling. It was founded to crack one of the big problems – the rate of attrition in the drug development pipeline.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

Drug Discovery World

SEPTEMBER 19, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Gene Therapy 52

Gene Therapy Gene Development Protein 52

Drug Discovery World

SEPTEMBER 12, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

Drug Discovery World

AUGUST 25, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality. However, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Gene Therapy 52

Gene Therapy Gene Development Genotype 52

Drug Discovery World

SEPTEMBER 5, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Development 59

Development Drugs Protein Genotype 59

Drug Discovery World

SEPTEMBER 26, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Development 52

Development Drugs Protein Genotype 52