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The evolution of assays for immuno-oncology research

Drug Discovery World

Cancer is a complex heterogenous multistep disease characterised by uncontrolled cell proliferation combined with a dysregulated immune response. A healthy immune system is naturally primed to eliminate malignant and abnormal cells through a synchronised and dynamic interplay between adaptive and innate immunity.

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Delivering on the promise of gene editing

Drug Discovery World

While viral vectors can be highly active, they can lead to only transient expression (rAAV, AdV), can lead to adverse immune responses (AdV) or can integrate randomly into the genome (LV). In all cases, viral delivery vectors have limited payload capacity which can limit various use cases.