Remove tag central-nervous-system
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Cannabinoids receptors: popular preclinical target but banned in 137 countries

Pharmaceutical Technology

CB1 receptors are primarily expressed in the brain and central nervous system, whereas CB2 receptors are expressed in T-cells in the immune system. Figure 1 shows the targets in preclinical trials for central nervous system diseases, as sourced from GlobalData’s Drugs Database.

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Cost of disease-modifying therapies for multiple sclerosis continues to rise in US

Pharmaceutical Technology

Multiple sclerosis (MS) is a primary autoimmune disease in which inflammation is a core contributor to the degeneration of the central nervous system (CNS), leading to neurological disability and affecting sensory, visual, motor, and autonomic systems. DMTs for MS have a high price tag, particularly in the US.

Marketing 246
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Leading innovators in peptide nano-particle conjugates for the pharmaceutical industry

Pharmaceutical Technology

Innovation S-curve for the pharmaceutical industry Peptide nano-particle conjugates is a key innovation area in the pharmaceutical industry By tagging peptides with nanoparticles, peptide nano-particle conjugates allow enhanced control over their biological behaviour, overcoming intrinsic limitations of the individual materials.

Antibody 130
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Beam makes USD 120M bet; GRAIL and Quest announce the collaboration; Brain organoids mimic infant’s brains; Improvement in T cells to kill cancer

Delveinsight

The company’s in vivo therapies reach the eye and central nervous system via adeno-associated viruses, while its liver therapies employ lipid nanoparticles (LNPs). Earlier, the prescription-only blood test will only be available through partner health systems, medical practices, and self-insured employers.

DNA 52
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Perfusion MRI and Other Perfusion Imaging Techniques for Clinical Trials

XTalks

Perfusion is the passage of fluid through the lymphatic system or the circulatory system to an organ or tissue, and it typically refers to the delivery of blood to a capillary bed in tissue. The other option is to tag just one of the feeder vessels to the liver, but that does not capture the full blood flow in the liver.”.

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Roche’s anti-amyloid beta antibody gantenerumab granted FDA Breakthrough Therapy Designation in Alzheimer’s disease

The Pharma Data

This designation is predicated on data showing that gantenerumab significantly reduced brain amyloid pillar, a pathological hallmark of Notice, in the ongoing SCarlet RoAD and Marguerite RoAD open- tag extension trials, as well as other studies.

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Unveiling Potential: Exploring Alpha Emitter Radiopharmaceuticals

XTalks

There is a small but real risk of extravasation as well as a known systemic effect with intravenous administration. This biological variability adds complexity, but with that complexity comes the power to choose the targets, the tags and the payloads and select combinations appropriate to the patient to personalize that therapy.

DNA 66