Scienmag

DECEMBER 1, 2020

Tagging produces detailed catalog of transcription factors key to making each cell type Credit: Gersbach Lab, Duke University DURHAM, N.C. – A team of biomedical engineers at Duke University has created a new way to turn stem cells into a desired cell type by mastering the language of gene regulatory networks.

Engineer 52

Engineer Gene Bioinformatics 52

The Pharma Data

MARCH 7, 2022

Cas9 binds and uses RNA as an address-tag. The system allows scientists, by synthesizing a specific “address-tag” RNA, to bring Cas9 to a precise location in genome and therefore cut and splice genes at specific sites. Ruohola-Baker and Levy then fused this designed protein with a disabled version of a protein called Cas9.

Protein 52

Protein Gene Genome Genomics 52

Delveinsight

DECEMBER 3, 2020

The researchers concentrated on the “Yamanaka factors,” which are four transcription factors—Oct4, Sox2, Klf4 and c-Myc. Shinya Yamanaka discovered that the factors could alter the epigenome, and in that way modify mature cells back to a stem cell-like state. Merck chooses TriNKET cancer immunotherapy program.

Gene Therapy 52

Gene Therapy Gene Antibody Research 52