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Neutralizing antibodies protect against severe COVID-19

Scienmag

Scientists at the Ragon Institute of MGH, MIT and Harvard find that neutralizing antibody potency predicts severe or fatal COVID-19. BOSTON — Understanding the body’s immune response to SARS-CoV-2, the virus that causes COVID-19, is key to developing effective treatments and long-lasting vaccines.

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This week in drug discovery (8-12 January) 

Drug Discovery World

The top stories: Excitement over new antibiotics that can kill drug-resistant bacteria A novel antibiotic class targeting a major global pathogen and threat to human health has been discovered by scientists from Roche and Harvard University (Cambridge, MA, US).

Drugs 52
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Finding clues to a successful immune response in the T cells of COVID-19 patients

Scienmag

While antibodies may fade fast, T cells appear to be long-lived and might confer lasting immunity.

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Zydus starts Phase II COVID-19 vaccine trial; Taysha raises $95M; FDA declines DBV’s peanut allergy patch; Combating COVID-19 with decoy target

Delveinsight

By ordering human cells to make the protein, ZyCoV-D could cause an immune response against the coronavirus. Scientists have already isolated many highly potent neutralizing antibodies from patients who recovered from COVID-19. FDA turns back peanut allergy patch of DBV Technologies.

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New Research Shows IBS Symptoms May be Caused by Gut Infections

XTalks

Researchers at KU Leuven in Belgium have found a potential mechanism underlying irritable bowel syndrome (IBS) that involves activation of immune cells primed by past gastrointestinal infections. However, IBS patients do not have allergies to any given foods, nor any gastrointestinal conditions, such as celiac disease.

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Mutations leading to omicron variant did not enable virus to fully escape immune system

The Pharma Data

That’s because the mutations that led to the variant’s emergence aren’t found in the regions of the virus that stimulates one type of cellular immune response, says an international research team from Johns Hopkins Medicine, in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) and ImmunoScape, a U.S.-Singapore

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Moderna’s COVID-19 vaccine trial; Freenome secures $270 M; CRISPR treats obesity in mice; Breast cancer research updates

Delveinsight

Moderna’s COVID-19 vaccine triggers an immune response in older adults. The phase 1 study that is being run by the National Institute of Allergy and Infectious Diseases tests three dose levels of the vaccine, mRNA-1273, given in two injections a month apart in 120 adults.