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Sanford Burnham Prebys receives $3M NIH award for drugs that restore immune response to COVID-19

Scienmag

Scientists will study how SARS-CoV-19 hijacks the immune system and creates a ‘cytokine storm’ Credit: Sanford Burnham Prebys Medical Discovery Institute.

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This week in drug discovery (8-12 January) 

Drug Discovery World

The top stories: Excitement over new antibiotics that can kill drug-resistant bacteria A novel antibiotic class targeting a major global pathogen and threat to human health has been discovered by scientists from Roche and Harvard University (Cambridge, MA, US).

Drugs 52
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Zydus starts Phase II COVID-19 vaccine trial; Taysha raises $95M; FDA declines DBV’s peanut allergy patch; Combating COVID-19 with decoy target

Delveinsight

By ordering human cells to make the protein, ZyCoV-D could cause an immune response against the coronavirus. Scientists have already isolated many highly potent neutralizing antibodies from patients who recovered from COVID-19. FDA turns back peanut allergy patch of DBV Technologies. The agency raised no safety concerns.

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The Lancet: New polio vaccine against strain that threatens eradication is safe and generates immune response in adults, young children, and infants

Scienmag

Scientists have developed the first poliovirus […].

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Deeper insight into how tick spit suppresses cattle immunity

Scienmag

Credit: itabajara da Silva Vaz Jr) A tick saliva study reveals immune responses that could lead to better protection for cattle.

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Finding clues to a successful immune response in the T cells of COVID-19 patients

Scienmag

While antibodies may fade fast, T cells appear to be long-lived and might confer lasting immunity.

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Experimental vaccine protects against deadly Sudan virus

Drug Discovery World

One of these candidates is VSV-SUDV, developed and tested by scientists at NIH’s National Institute of Allergy and Infectious Diseases in Hamilton, Montana. The fact that four control animals got sick demonstrates that pre-existing immunity to EBOV and VSV-EBOV has limited effect on protection from SUDV.