Allergies, Development and Medicine - Clinical Research Informer

RVAC and University of Pennsylvania to develop mRNA vaccines

Pharmaceutical Technology

MARCH 20, 2023

RVAC Medicines has announced a research collaboration with the University of Pennsylvania (Penn) for the discovery and development of mRNA vaccines. The partnership will focus on developing potential new vaccines to treat certain selected autoimmune indications, as well as food allergies.

Vaccination

Vaccination Vaccine Development Allergies

Tiny molecules in breast milk may protect infants from developing allergies

Medical Xpress

NOVEMBER 15, 2022

Breastfed babies are believed to suffer fewer allergic conditions, like eczema and food allergies, than formula-fed babies; yet the reason has not been well understood.

Allergies

Allergies Development Medicine

Black, Hispanic severe allergy patients less likely to receive allergy shots

Medical Xpress

APRIL 6, 2023

Black and Hispanic patients with severe allergies are less likely to get a common treatment, allergen immunotherapy, compared to white patients, according to Penn State College of Medicine researchers.

Allergies

Allergies Medicine Development Research

Re-examining antibodies' role in childhood allergies

Medical Xpress

DECEMBER 2, 2022

The presence of food-specific IgA antibodies in the gut does not prevent peanut or egg allergies from developing in children, according to a Northwestern Medicine study published in Science Translational Medicine.

Allergies

Allergies Antibody Medicine Development

Food allergies, changes to infant gut bacteria linked to method of childbirth, ethnicity

Scienmag

APRIL 20, 2021

Babies born by caesarean section to mothers of Asian descent are eight times more likely to develop peanut allergy by age three, study shows Credit: Faculty of Medicine & Dentistry, University of Alberta Researchers have found a causal link between caesarean section birth, low intestinal microbiota and peanut sensitivity in infants, and they report (..)

Allergies

Allergies Bacteria Medicine Development

Maternal Antibodies: How Allergies Can be Passed from Mothers to Children

XTalks

NOVEMBER 4, 2020

It has long been known that mothers greatly influence the development of the growing fetus by not only providing nutrients through the placenta, but also a growing list of biological elements including beneficial antibodies, gut bacteria and now, allergies. Related: Red Meat Allergy Test Gets FDA Clearance.

Allergies

Allergies Antibody In-Vitro Development

Tackling food allergies at the source

Scienmag

NOVEMBER 17, 2020

Credit: Eliot Herman Food allergies are a big problem. suffer from some kind of food allergy. These allergies cost a whopping $25 billion in health care each year. About 7% of children and 2% of adults in the U.S. Then there’s the time lost at school or work.

Allergies

Allergies Genetics Development Research

Coronavirus vaccine may have allergy warning in US, says expert

pharmaphorum

DECEMBER 10, 2020

Moncef Slaoui, co-head of the US government’s Operation Warp Speed COVID-19 vaccine programme, made the comments after the UK drugs regulator advised those with severe allergies to avoid the vaccine. The post Coronavirus vaccine may have allergy warning in US, says expert appeared first on.

Allergies

Allergies Vaccination Vaccine Regulation

Rensselaer team receives NIAID grant to develop antiviral drug for Covid-19

Pharmaceutical Technology

JUNE 28, 2022

grant from the National Institutes of Health (NIH) unit National Institute of Allergy and Infectious Diseases (NIAID) for developing a Covid-19 oral antiviral drug. award to researchers at Michigan State University to develop artificial intelligence algorithms that could predict crucial features with the evolution of viruses.

Development

Development Bioinformatics Drugs Allergies

LASTACAFT® Provides Eye Allergy Itch Relief in Minutes that Lasts Through 16 Hours

The Pharma Data

MARCH 15, 2022

Itchy allergy eyes affect an estimated 40% of Americans 1. Allergan, an AbbVie (NYSE: ABBV) company, today announced that LASTACAFT ® (alcaftadine ophthalmic solution 0.25%) is now available without a prescription for the estimated 40% of Americans 1 who live with ocular allergies. 2 Following the recent U.S.

Allergies

Allergies Production Containment Medicine

Fewer Food Allergies in Kids If Mom Drinks Milk While Breastfeeding: Study

The Pharma Data

JANUARY 4, 2021

4, 2021 — Mothers who drink cow’s milk while breastfeeding may reduce their child’s risk of developing food allergies , a new Swedish study suggests. The findings held after the researchers took into account other factors known to increase allergy risk in children, such as genetics. MONDAY, Jan.

Allergies

Allergies Doctors Doctor Dermatology

$12 million awarded for the development of antiviral therapies

Drug Discovery World

NOVEMBER 24, 2022

Three institutions have received a share of $12 million for the development of antiviral therapies to treat diseases caused by viruses with pandemic potential. . The money was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. NIAID may award approximately $61.5

Development

Development Allergies Production Drugs

Overactive food quality control system triggers food allergies, Yale scientists say

Scienmag

JANUARY 14, 2021

Food allergies have been increasing dramatically across the developed world for more than 30 years. For instance, as many as 8% of children in the U.S. now experience potentially lethal immune system responses to such foods as milk, tree nuts, fish and shellfish. But scientists have struggled to explain why that is.

Allergies

Allergies Scientist Development Medicine

Webinar Recap: Unleashing the Power of PROs Throughout Oncology Drug Development

VirTrial

FEBRUARY 28, 2024

If you missed Signant’s February 2024 webinar about optimizing patient-reported outcomes measurement strategy throughout oncology drug development, we’ve summarized the key takeaways and provided a link for you to watch the recording. Meet the Experts Anthony Everhart, MD, FACP , is the internal medicine leader at Signant.

Development

Development Drugs Trials Clinical Development

TAS-117 by Taiho Pharmaceutical for Chondrosarcoma: Likelihood of Approval

Pharmaceutical Technology

JUNE 10, 2023

TAS-117 is under clinical development by Taiho Pharmaceutical and currently in Phase II for Chondrosarcoma. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data.

Allergies

Allergies Production Clinical Trials Clinical Trials

TAS-117 by Taiho Pharmaceutical for Chondrosarcoma: Likelihood of Approval

Pharmaceutical Technology

JUNE 10, 2023

TAS-117 is under clinical development by Taiho Pharmaceutical and currently in Phase II for Chondrosarcoma. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data.

Allergies

Allergies Production Clinical Trials Clinical Trials

Gene variants help explain connection between skin disorder and food allergy risk

Scienmag

AUGUST 14, 2020

Discovery could lead to new screening tests and potential treatments Credit: Cincinnati Children’s Two common variants in the KIF3A gene increase the risk of young children having a dysfunctional skin barrier and developing the skin condition atopic dermatitis.

Allergies

Allergies Gene Development Dermatology

University of Alberta virologist awarded Nobel Prize in Physiology or Medicine

Scienmag

OCTOBER 5, 2020

Michael Houghton discovered hepatitis C virus and now is developing a vaccine Credit: Photo: Michael Holly Michael Houghton was awarded the 2020 Nobel Prize in Physiology or Medicine today in recognition of his discovery of the hepatitis C (HCV) virus.

Medicine

Medicine Vaccination Vaccine Development

Infant antibiotic exposure can affect future immune responses toward allergies

Scienmag

APRIL 1, 2021

Early life exposure to antibotics in utero and through mother’s milk disrupts beneficial gut bacteria, compromising T-cell development, Rutgers research shows Exposure to antibiotics in utero and infancy can lead to an irreversible loss of regulatory T-cells in the colon-a valuable component of the immune system’s response toward allergens (..)

Immune Response

Immune Response Allergies Bacteria Development

Scripps Research awarded $67 million by NIH to lead new Pandemic Preparedness Center

Scienmag

MAY 18, 2022

LA JOLLA, CA—The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), is sponsoring a major new antiviral drug development center that will be led by Scripps Research.

Allergies

Allergies Research Development Drugs

DUPIXENT® (DUPILUMAB) LATE-BREAKING PHASE 3 COPD RESULTS PRESENTED AT ATS AND SIMULTANEOUSLY PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE

The Pharma Data

MAY 22, 2023

DUPIXENT® (DUPILUMAB) LATE-BREAKING PHASE 3 COPD RESULTS PRESENTED AT ATS AND SIMULTANEOUSLY PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE Regeneron Pharmaceuticals, Inc. The Dupixent Phase 3 results were presented in the 2023 American Thoracic Society (ATS) International Conference session “New England Journal of Medicine and JAMA.

Medicine

Medicine Allergies Trials Clinical Trials

How allergens trigger itching: Finding points to new targets for allergy drug development

Scienmag

OCTOBER 29, 2020

A key step in the immune system’s response to allergens has been uncovered by researchers at Massachusetts General Hospital. BOSTON – A key step in the immune system’s response to allergens has been uncovered by researchers at Massachusetts General Hospital (MGH).

Allergies

Allergies Development Drugs Research

Merck gives taxpayers the middle finger

World of DTC Marketing

OCTOBER 6, 2021

SUMMARY: Via Axios – The antiviral pill that showed promising results against severe COVID-19 was initially developed at Emory University with $35 million of taxpayer grants. government $712 for the same amount of medicine or 40 times the price. originally developed it to treat other viral diseases. The Intercept.

Clinical Trials

Clinical Trials Clinical Trials Allergies Trials

PCOS in mothers is linked to increased risk of health problems in their children

Scienmag

JULY 13, 2022

Children born to mothers with polycystic ovary syndrome (PCOS) have an increased risk of developing infections, allergies and other childhood illnesses by the age of 13, according to the largest study to investigate this.

Allergies

Allergies Medicine Development

New pre-clinical model could hold the key to better HIV treatments

Scienmag

MAY 14, 2021

Credit: National Institute of Allergy and Infectious Diseases/NIH A team led by researchers at Weill Cornell Medicine and Children’s National Hospital has developed a unique pre-clinical model that enables the study of long-term HIV infection, and the testing of new therapies aimed at curing the disease.

Allergies

Allergies Medicine Development Research

HIV vaccines suffer setbacks but new approaches could turn the tide

Pharmaceutical Technology

FEBRUARY 3, 2023

The failure of several late-stage trials highlights the challenging nature of HIV vaccine development. Since HIV integrates with the DNA, eliminating the virus from the body is very difficult, explains David Montefiori, PhD, director of the Laboratory for AIDS Vaccine Research and Development at Duke University in Durham, North Carolina.

Vaccination

Vaccination Vaccine Antibody Trials

Topline Results from NIH-Sponsored Clinical Trial of Investigational COVID-19 Hyperimmune Globulin Medicine

The Pharma Data

APRIL 3, 2021

The CoVIg-19 Plasma Alliance today announced that the Phase 3 Inpatient Treatment with Anti-Coronavirus Immunoglobulin (ITAC) clinical trial sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), did not meet its endpoints.

Clinical Trials

Clinical Trials Clinical Trials Medicine Trials

Asthma Drug Xolair Wins FDA Approval as First Treatment for Multiple Food Allergies

XTalks

FEBRUARY 26, 2024

The class of IgE-mediated food allergies includes 160 foods, with peanuts, milk, eggs, wheat, soy and tree nuts being the most common ones. According to the Centers for Disease Control and Prevention (CDC), almost six percent of people in the US in 2021 had a food allergy. million children and 13.6

Allergies

Allergies FDA Approval Drugs Protein

Making wheat and peanuts less allergenic

Scienmag

JANUARY 26, 2021

Credit: Credit: Jonathan Windham The United States Department of Agriculture identifies a group of “big eight” foods that causes 90% of food allergies. Sachin Rustgi, a member of the Crop Science Society of America, studies how we can use breeding to develop less allergenic varieties of these foods. […].

Allergies

Allergies Development Medicine Research

Complexity in Early Phase Clinical Trials with Dr. Oren Cohen?

Clinical Trial Podcast

SEPTEMBER 26, 2022

To learn more about the complexities in early phase clinical trials, I invited Dr. Oren Cohen , President of Clinical Pharmacology Services and Chief Medical Officer at Labcorp Drug Development on the show. Dr. Cohen has more than 30 years of healthcare experience which includes his work on clinical development.

Clinical Trials

Clinical Trials Clinical Trials Trials Clinical Research

Speakers announced for SLAS2024 Ignite Theater: Register now

Drug Discovery World

DECEMBER 13, 2023

She will be followed by Andrea Bortolato, Director of Drug Discovery at SandboxAQ, at 3pm, who will speak on ‘Combining physics-based methods with AI solutions to maximise the probability of success and speed of drug discovery and development’.

Allergies

Allergies Engineer Drugs Development

TAKHZYRO® (lanadelumab) for Hereditary Angioedema Patients to be Presented at European Academy of Allergy and Clinical Immunology (EAACI) Hybrid Congress

The Pharma Data

JULY 11, 2021

3 These data are being presented at the 2021 European Academy of Allergy and Clinical Immunology (EAACI) Hybrid Congress in Krakow, Poland and Madrid, Spain. Traceability: In order to improve the traceability of biological medicinal products, the name and the batch number of the administered product should be clearly recorded.

Allergies

Allergies Antibody Recombinant DNA Technology Production

Most people infected with SARS-CoV-2 develop symptoms

Scienmag

SEPTEMBER 22, 2020

A new study published in the open-access journal PLOS Medicine by Diana Buitrago-Garcia at the University of Bern, Switzerland and colleagues […].

Development

Development Medicine Allergies

UCSF launches $250M initiative to develop living therapeutics

Scienmag

JUNE 14, 2021

Investments have catalyzed research, clinical trials and revolutionary treatments across many disciplines UC San Francisco is launching a new initiative to propel the development of living therapeutics – a category of treatments broadly defined as human and microbial living cells that are selected, modified, or engineered to treat or cure disease (..)

Development

Development Engineer Clinical Trials Clinical Trials

FDA approves first rescue medication to manage asthma inflammation

Drug Discovery World

JANUARY 12, 2023

It is being developed by AstraZeneca and Avillion. . Results from the MANDALA trial were published in the New England Journal of Medicine in May 2022. . The approval by the Food and Drug Administration (FDA) was based on results from the MANDALA and DENALI Phase III trials. .

FDA Approval

FDA Approval Allergies Trials Medicine

4th Inflammasome Therapeutics Summit 2022

pharmaphorum

NOVEMBER 11, 2022

Pick the brains of 140+ senior level drug developers across industry and academia at the physical return of the only meeting dedicated to overcoming challenges in biomarker understanding, disease selection and clinical translation in inflammasome-centered drug development. Download the full event guide here for the official agenda.

Allergies

Allergies Scientist Medicine Development

Researchers identify key marker to help speed development of CMV vaccines

Scienmag

NOVEMBER 4, 2020

The finding provides a surrogate for testing the effectiveness of vaccine candidates Credit: Jennifer Jenks, Duke University School of Medicine DURHAM, N.C.

Vaccination

Vaccination Vaccine Research Development

Scientists develop novel therapy for crimean-congo hemorrhagic fever virus

Scienmag

JUNE 1, 2021

Army scientists working as part of an international consortium have developed and tested an antibody-based therapy to treat Crimean-Congo hemorrhagic fever virus (CCHFV), which is carried by ticks and kills up to 60 percent of those infected. Their results are published online today in the journal Cell.

Scientist

Scientist Development Antibody Allergies

The Lancet Respiratory Medicine: Clinical trial finds inhaled immune response protein increases odds of recovery for hospitalised COVID-19 patients

Scienmag

NOVEMBER 12, 2020

Inhaled delivery of a formulation of a key protein involved in the immune response – interferon beta-1a – to hospitalised COVID-19 patients in the UK reduced the odds that they would develop severe disease or die from SARS CoV-2 infection.

Immune Response

Immune Response Protein Clinical Trials Clinical Trials

Idacio Approved as Eighth Adalimumab Biosimilar in the US

XTalks

DECEMBER 20, 2022

Idacio (adalimumab-aacf) is a citrate-free formulation of adalimumab developed by Fresenius Kabi and is now the eighth biosimilar of Humira (adalimumab) to be approved by the US Food and Drug Administration (FDA). In the United States, we are a leading manufacturer of small-molecule injectable medicines.

FDA Approval

FDA Approval Allergies Manufacturing Clinical Trials

Breathing easy: How digital inhalers are changing asthma treatment

Pharmaceutical Technology

APRIL 26, 2023

Electronic respiratory health company Adherium has also developed a digital inhaler system focusing on patient adherence, remote monitoring, and data management. There is also huge potential to use these data to inform future drug development and clinical trials of new asthma medication,” adds Chan.

Clinical Trials

Clinical Trials Clinical Trials Allergies Research

Doubts emerge over AZ’s ‘outdated’ US vaccine trial data

pharmaphorum

MARCH 23, 2021

The company’s share price ticked down after the statement on Monday from the US National Institute for Allergy and Infectious Diseases (NIAID). Regulators including the European Medicines Agency and the UK’s Medicines and Healthcare products Regulatory Agency have already approved it.

Vaccination

Vaccination Vaccine Trials Allergies

Scientists reach new milestone in vaccine development for leishmaniasis

Scienmag

JANUARY 11, 2021

Scientists reach new milestone in vaccine development for neglected tropical disease Researchers have taken an important step forward in developing a controlled human infection model to test leishmaniasis vaccines.

Scientist

Scientist Vaccination Vaccine Development

Do bacteria in the mouth affect risk of developing rheumatoid arthritis?

Scienmag

MAY 4, 2021

Investigators found similarities in the bacterial composition of the mouth among patients with early rheumatoid arthritis and those at risk of developing the disease, compared with healthy individuals who were not at risk. The findings come from a study published in Arthritis & Rheumatology.

Bacteria

Bacteria Development Allergies Medicine

RVAC and University of Pennsylvania to develop mRNA vaccines

Tiny molecules in breast milk may protect infants from developing allergies

Trending Sources

Black, Hispanic severe allergy patients less likely to receive allergy shots

Re-examining antibodies' role in childhood allergies

Food allergies, changes to infant gut bacteria linked to method of childbirth, ethnicity

Maternal Antibodies: How Allergies Can be Passed from Mothers to Children

Tackling food allergies at the source

Coronavirus vaccine may have allergy warning in US, says expert

Rensselaer team receives NIAID grant to develop antiviral drug for Covid-19

LASTACAFT® Provides Eye Allergy Itch Relief in Minutes that Lasts Through 16 Hours

Fewer Food Allergies in Kids If Mom Drinks Milk While Breastfeeding: Study

$12 million awarded for the development of antiviral therapies

Overactive food quality control system triggers food allergies, Yale scientists say

Webinar Recap: Unleashing the Power of PROs Throughout Oncology Drug Development

TAS-117 by Taiho Pharmaceutical for Chondrosarcoma: Likelihood of Approval

TAS-117 by Taiho Pharmaceutical for Chondrosarcoma: Likelihood of Approval

Gene variants help explain connection between skin disorder and food allergy risk

University of Alberta virologist awarded Nobel Prize in Physiology or Medicine

Infant antibiotic exposure can affect future immune responses toward allergies

Scripps Research awarded $67 million by NIH to lead new Pandemic Preparedness Center

DUPIXENT® (DUPILUMAB) LATE-BREAKING PHASE 3 COPD RESULTS PRESENTED AT ATS AND SIMULTANEOUSLY PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE

How allergens trigger itching: Finding points to new targets for allergy drug development

Merck gives taxpayers the middle finger

PCOS in mothers is linked to increased risk of health problems in their children

New pre-clinical model could hold the key to better HIV treatments

HIV vaccines suffer setbacks but new approaches could turn the tide

Topline Results from NIH-Sponsored Clinical Trial of Investigational COVID-19 Hyperimmune Globulin Medicine

Asthma Drug Xolair Wins FDA Approval as First Treatment for Multiple Food Allergies

Making wheat and peanuts less allergenic

Complexity in Early Phase Clinical Trials with Dr. Oren Cohen?

Speakers announced for SLAS2024 Ignite Theater: Register now

TAKHZYRO® (lanadelumab) for Hereditary Angioedema Patients to be Presented at European Academy of Allergy and Clinical Immunology (EAACI) Hybrid Congress

Most people infected with SARS-CoV-2 develop symptoms

UCSF launches $250M initiative to develop living therapeutics

FDA approves first rescue medication to manage asthma inflammation

4th Inflammasome Therapeutics Summit 2022

Researchers identify key marker to help speed development of CMV vaccines

Scientists develop novel therapy for crimean-congo hemorrhagic fever virus

The Lancet Respiratory Medicine: Clinical trial finds inhaled immune response protein increases odds of recovery for hospitalised COVID-19 patients

Idacio Approved as Eighth Adalimumab Biosimilar in the US

Breathing easy: How digital inhalers are changing asthma treatment

Doubts emerge over AZ’s ‘outdated’ US vaccine trial data

Scientists reach new milestone in vaccine development for leishmaniasis

Do bacteria in the mouth affect risk of developing rheumatoid arthritis?

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