AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 11, 2024

Using viruses that infect bacteria to detect proteins sprouted by a notorious parasite, scientists have honed in on possible vaccine targets for schistosomiasis, a neglected tropical disease that currently affects an estimated 600 million people worldwide, causing 280,000 deaths per year.

Vaccination 175

Vaccination Vaccine Bacteria Protein 175

AuroBlog - Aurous Healthcare Clinical Trials blog

DECEMBER 20, 2022

Restricting our food intake can result in a range of health benefits, including reducing the risk of obesity. But when the dieting stops, the weight often piles back on, and a new study in mice may have identified why. link] Scientists from the Shanghai Institute of Nutrition and the Chinese Academy of Sciences think they […].

Bacteria 215

Bacteria Scientist Clinical Trials Clinical Trials 215

Drug Discovery World

APRIL 10, 2023

RESP-X, Infex Therapeutics’ anti-virulence therapy to treat Pseudomonas aeruginosa (Pa) infections in non-cystic fibrosis bronchiectasis (NCFB) patients, has shown a promising interim safety and tolerability profile in its ongoing first-in-human Phase I clinical trial.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Bacteria 52

AuroBlog - Aurous Healthcare Clinical Trials blog

OCTOBER 26, 2023

Many tiny organisms including bacteria, fungi and viruses normally live on our bodies, and even inside us. These are called the microbiome. The large number of these organisms living in the gastrointestinal tract are collectively known as the gut microbiome.

Bacteria 215

Bacteria Clinical Trials Clinical Trials Clinical Research 215

XTalks

JULY 31, 2020

A study published in Nature on July 30, 2020 states that good bacteria living in our gut can do much more than just help digest food and boost our immune system. According to studies conducted by researchers at Cincinnati Children’s Hospital, the bacteria can help heal damaged intestinal tissues.

Bacteria 98

Bacteria Genetic Engineering Engineer Research 98

AuroBlog - Aurous Healthcare Clinical Trials blog

JANUARY 11, 2024

Researchers have identified an entirely new class of antibiotic that can kill bacteria that are resistant to most current drugs.

Bacterium 182

Bacterium Bacteria Drugs Research 182

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Using Bacteria For Therapy. Some trials had to be terminated due to severe toxicity.”

Bacteria 52

Bacteria Engineer Drugs Research 52

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 28, 2023

Golden staph are ubiquitous bacteria, living harmlessly on the skin or inside the nose of nearly one in three people worldwide. Yet they are duplicitous, too. In some situations, golden staph (Staphylococcus aureus) can become monsters, causing dangerous infections in the skin, blood, bones, or elsewhere.

Scientist 212

Scientist Bacteria Drugs Clinical Trials 212

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 14, 2023

Called the gut microbiome, this dazzling collection of bacteria and other microorganisms has been the source of much attention – linked to a vast array of health conditions, from autism spectrum disorder and diabetes, to depression, […]

Bacteria 174

Bacteria Clinical Trials Clinical Trials Clinical Research 174

Pfizer

FEBRUARY 16, 2023

These study participants, representing approximately half of the total recruited participants in the trial, are being discontinued following violations of Good Clinical Practice (GCP) at certain clinical trial sites run by a third-party clinical trial site operator. FDA in July 2017.

Clinical Trials 76

Clinical Trials Clinical Trials Vaccination Vaccine 76

Drug Discovery World

APRIL 26, 2024

The leading news story this week has been the launch of a new clinical trial in the UK for a melanoma personalised mRNA cancer vaccine, but there have been a number of other interesting developments in cancer drug discovery. News round-up for 22-26 April by DDW Digital Content Editor Diana Spencer.

Clinical Trials 52

Clinical Trials Clinical Trials Drugs Bacteria 52

Scienmag

MARCH 11, 2021

A new clinical study has shown that supplements of a lactic acid bacterium may have positive effects by increasing the diversity of intestinal bacteria in these infants. Extremely preterm infants can suffer from a life-threatening inflammation of the gut.

Bacteria 72

Bacteria Bacterium Research Clinical Trials 72

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 2, 2022

Scientists have discovered DNA-damaging molecules made by gut bacteria that may help explain why people with inflammatory bowel disease (IBD) have higher rates of colorectal cancer than those without the condition.

DNA 196

DNA Bacteria Scientist Research 196

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 9, 2022

Instead of the vaccine only protecting against the target bacteria – Myocbacterium tuberculosis – the tuberculosis vaccine offered broad protection against a range of unrelated infections, including respiratory infections and serious complications such as sepsis.

Vaccination 208

Vaccination Vaccine Bacteria Research 208

Pharmaceutical Technology

DECEMBER 14, 2022

Bacteria naturally develop resistance to antibiotics over time, through genetic mutation, horizontal gene transfer between bacteria, or because of selective pressure. Virus versus bacteria. Phages are viruses of bacteria. Secondly, the relationships between phages and bacteria are very specific.

Bacteria 130

Bacteria DNA Clinical Trials Clinical Trials 130

Medical Xpress

APRIL 17, 2023

A randomized clinical trial is looking at whether fecal microbiota transplantation (FMT) from healthy donors into adults with early-stage amyotrophic lateral sclerosis (ALS—one of the most common forms of motor neuron disease) can modulate the immune reaction during inflammation responses that characterize disease progression, and aims to investigate (..)

Bacteria 98

Bacteria Clinical Trials Clinical Trials Trials 98

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 7, 2022

In cases where picking at your nose damages internal tissues, critical species of bacteria have a clearer path to the brain, which responds to their presence in ways that resemble signs of Alzheimer’s disease. […].

Bacteria 130

Bacteria Development Clinical Trials Clinical Trials 130

Pharmaceutical Technology

OCTOBER 6, 2022

Additionally, it will work on non-clinical toxicity (TOX) and Clinical Trial Material batch to conduct a Phase I clinical trial of the vaccine in healthy adult subjects. This trial will evaluate the safety of the vaccine and generate efficacy data.

Vaccination 147

Vaccination Vaccine Development Bacterium 147

AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 22, 2022

The research involves using spherical vesicles secreted by bacteria coated on gold nanoparticles which can then be delivered to the immune cells. The Indian Institute of Science (IISc), Centre for BioSystems Science and Engineering, has designed a new method to deliver a vaccine candidate for tuberculosis (TB).

Vaccination 100

Vaccination Vaccine Research Bacteria 100

Medical Xpress

JANUARY 17, 2023

A promising approach to control Staphylococcus aureus bacterial colonization in people—using a probiotic instead of antibiotics—was safe and highly effective in a Phase 2 clinical trial. aureus colonization in trial participants without harming the gut microbiota, which includes bacteria that can benefit people.

Trials 81

Trials Allergies Bacteria Clinical Trials 81

Delveinsight

JANUARY 28, 2021

Nirogy’s lead program aims lactate transporters for cancer treatment and is anticipated to enter human clinical trials in 2022. The NDA submission comprises data from the SURE-1, SURE-2 and SURE-3 phase 3 clinical trials, in which oral sulopenem was well tolerated with no major drug-related adverse events.

Bacteria 52

Bacteria Trials Drugs Clinical Trials 52

Drug Discovery World

JANUARY 24, 2023

Dr Kaustav Das Gupta and Professor Matt Sweet from UQ’s Institute for Molecular Bioscience discovered that a molecule derived from glucose in immune cells can both stop bacteria growing and dampen inflammatory responses. Coli bacteria from growing,” Dr Das Gupta said. “It

Scientist 52

Scientist Bacteria Clinical Trials Clinical Trials 52

Pharmaceutical Technology

JUNE 14, 2023

The therapy comprises liposomes engineered to capture the virulence factors, which are produced by a wide range of Gram-positive and Gram-negative bacteria. The company is currently evaluating CAL02 in a Phase II clinical trial, which is expected to enrol 276 SCABP patients globally.

Bacteria 130

Bacteria Engineer Clinical Trials Clinical Trials 130

Pharmaceutical Technology

MARCH 4, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The therapeutic candidate comprises of consortia of immune-modulating microbiome-derived bacteria. VE-818 overview VE-818 is under development for the treatment of graft versus host disease (GVHD).

Bacteria 100

Bacteria Clinical Trials Clinical Trials Clinical Development 100

Pharmaceutical Technology

MARCH 4, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The therapeutic candidate comprises of consortia of immune-modulating microbiome-derived bacteria. VE-818 overview VE-818 is under development for the treatment of graft versus host disease (GVHD).

Bacteria 100

Bacteria Clinical Trials Clinical Trials Clinical Development 100

Rethinking Clinical Trials

JUNE 6, 2023

“We have a tool that not only flags a low-risk patient, but is doing it based on data from the EMR [electronic medical record] system, and is calculating risk specific to a patient, specific to a disease, and specific to a type of bacteria, and one that is unique to a hospital.

Trials 130

Trials Clinical Trials Clinical Trials Allergies 130

Drug Discovery World

JULY 17, 2023

Paul Denslow , CEO, Intus Bio, discusses how a new approach to tracking gut bacteria can revolutionse our understanding of the microbiome and bring about new discoveries for therapeutics. It’s a long-held doctrine that there’s no effective method to track the microbiome during drug research and development.

Bacteria 52

Bacteria Drugs Gene Immune Response 52

Pharmaceutical Technology

MARCH 4, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The drug candidate is consortia of live bacteria based on microbiome-derived live biotherapeutic.

Bacteria 100

Bacteria Clinical Trials Clinical Trials Drugs 100

Pharmaceutical Technology

MARCH 4, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The drug candidate is consortia of live bacteria based on microbiome-derived live biotherapeutic.

Bacteria 100

Bacteria Clinical Trials Clinical Trials Drugs 100

Drug Discovery World

JANUARY 18, 2023

The first patient has been treated in everImmune’s Phase I clinical trial evaluating its oncobiotic drug candidate Oncobax AK in lung and kidney cancer patients. . The aim of the trial is to assess the toxicity and efficacy of Oncobax AK when administered alongside an immunotherapy treatment. .

Drugs 52

Drugs Clinical Trials Clinical Trials Bacteria 52

BioTech 365

SEPTEMBER 11, 2020

Italian clinical study finds combined strains of live bacteria reduced diarrhea and prevented progression of symptoms in hospitalized COVID19-patients LAUSANNE, Switzerland–(BUSINESS WIRE)–Ormendes SA is proud to announce that one of its probiotic formulations has been used in a clinical study … Continue reading →

Clinical Trials 40

Clinical Trials Clinical Trials Bacteria Trials 40

Scienmag

APRIL 19, 2021

Researchers from Aarhus University and Aarhus University Hospital replace sick intestinal bacteria with intestinal bacteria from healthy donors in a treatment intended to help patients with cirrhosis of the liver. The Novo Nordisk Foundation supports the Credit: Simon Mark Dahl Baumwall.

Bacteria 94

Bacteria Research Clinical Trials Clinical Trials 94

Drug Discovery World

APRIL 14, 2023

The top stories: Australian sepsis study to power new antibiotic discoveries University of Queensland (UQ) researchers have led a national study on the four main bacteria that cause sepsis, providing new targets for developing antibiotics.

Drugs 52

Drugs Bacteria Vaccination Vaccine 52

Sciensano

MARCH 27, 2024

Investigations show that these counterfeit ivermectin tablets are systematically underdosed or seriously contaminated with bacteria. Although several health authorities warned the public against using this medicine outside clinical trials, the medicine was widely used on a major scale in late 2020 and in 2021.

Contamination 52

Contamination Bacteria Packaging Packaging 52

Drug Discovery World

MARCH 27, 2024

billion people estimated to be infected with the bacteria, according to the World Health Organization (WHO). The day aims to raise awareness about the devastating health, social, and economic consequences of the disease. TB remains a global pandemic, with 1.8 This year’s theme is ‘Yes, we can end TB!’

Vaccination 52

Vaccination Vaccine Bacteria Clinical Trials 52

XTalks

MAY 31, 2022

Tapinarof was discovered as an outcome of investigations into the secondary metabolites of Photorhabdus luminescens, a bioluminescent, Gram-negative bacteria. XTALKS WEBINAR: All Means All: The Road to Inclusivity in Clinical Trials. Clinical Trials of Vtama. There is 10 mg of tapinarof per gram of Vtama cream.

FDA Approval 98

FDA Approval Clinical Trials Clinical Trials Trials 98

XTalks

DECEMBER 2, 2022

difficile as certain antibiotics can disrupt the balance of bacteria in the gut, allowing bacteria like C. While Rebyota is the first of its kind pharmaceutical therapy, the concept of healing the gut via fecal matter-derived bacteria is not new. The use of certain antibiotics can contribute to infection caused by C.

FDA Approval 59

FDA Approval Bacteria Clinical Trials Clinical Trials 59