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Scientists engineer safe, virus-resistant E coli for research

Drug Discovery World

In a step forward for genetic engineering and synthetic biology, US researchers have modified E coli bacteria to be immune to infection by all natural viruses tested so far. The team used two safeguard methods to prevent the bacteria and their modified genes from escaping into the wild.

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Biopharmaceutical Filtration: A Deep Dive

Roots Analysis

Biopharmaceutical filtration is a critical step in the production of biopharmaceuticals, including proteins, antibodies, and vaccines. It involves the separation of unwanted particles from biological materials to obtain contaminant free products. For example, ultrafiltration retains proteins, allowing other molecules to pass through.

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Improving quality control for CAR T cell therapies

Drug Discovery World

The immune system typically identifies foreign entities such as bacteria and viruses and activates lymphocytes such as T cells to destroy them with overwhelming force. To overcome this evasion tactic, the CAR protein was developed to recognise other markers on cancer cells. Identifying the right CAR T cell target.