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Gene Therapy and Pharmacokinetics

Camargo

The technology of gene therapy is possible due to extensive DNA research and our resulting understanding of many diseases on the genetic level, and it encompasses several mechanisms such as introducing new genes (gene addition) and inactivating or replacing mutated genes (gene editing). Formulation Considerations.

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Leading innovators in coronavirus vaccine components

Pharmaceutical Technology

The key component in all vaccines is one or more active ingredients made from viruses or bacteria, also called antigens, which generates an immune response. The active component of the Pfizer-BioNTech vaccine tozinameran, contains the genetic code for the coronavirus spike protein, inside a lipid (fat) capsule.

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Mutations leading to omicron variant did not enable virus to fully escape immune system

The Pharma Data

People who gained immunity – either through vaccination or exposure – against the original strain of SARS-CoV-2, the virus that causes COVID-19, also are likely to have some protection against the pathogen’s omicron variant. The samples were stored after the researchers measured the T cell response. population.

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mRNA vaccine 100% effective against deadly bacteria

Drug Discovery World

For the first time, researchers have developed an mRNA vaccine that is 100% effective against a type of bacteria that is lethal to humans, paving the way for effective vaccination against antibiotic-resistant bacteria. However, until now scientists believed that mRNA vaccines against bacteria were biologically undoable.

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Research Roundup: Different Antibody Responses to COVID-19 and More

The Pharma Data

People with severe COVID-19 have low proportions of antibodies that target the spike protein. In milder cases, the antibodies seem to do a better job of binding to the spike protein. The spike protein binds to the ACE2 receptor on human cells, which allows the virus to enter the cell.

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Mouse study findings suggest new approach to treating Alzheimer’s 

Drug Discovery World

Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage. The mice were genetically modified to express a mutant form of the human brain protein tau, which builds up and causes damage to neurons and atrophy of their brains by nine months of age.

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Research Roundup: Blood Test for Severe COVID-19 and More

The Pharma Data

They are now working to identify what genetic aberrations are causing ALS in about half of the Maltese patients. How the Immune System Drives Brain Aging. The initial work involved infecting mice with a stomach infection while feeding them ovalbumin, a protein in egg white that is often used as a model food antigen.