pharmaphorum
AUGUST 5, 2021
Whereas targets like receptors contain an obvious ligand-binding site for drug molecules to interact with, PPIs comprise a more complex structure. The interface is highly hydrophobic, hence any compounds containing water would be repelled. Current challenges and conventional approaches in targeting PPIs.
Drug Discovery World
AUGUST 12, 2022
This has an important knock-on effect if the compound’s MF and MW are calculated algorithmically from the structure diagram, as they may no longer accurately reflect the effective MF value which has been normalised to the version of the salt/hydrate that contains a single molecule of the parent compound. Suppose you want to makeup a 0.1
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Drug Discovery World
MAY 4, 2023
Here, new bioassay technologies helped testing, but more definite answers were required. Expression patterns, proteomic profiles, bioassay results, and structures could now be captured en masse in normal and disease conditions. The MorCVD database contains all the human proteins that can be potentially involved in heart disease.
Drug Discovery World
NOVEMBER 30, 2023
The poster shows how the company systematically built and evaluated 17 bispecific designs, including a number of well-utilised formats, in order to find that Fc-containing formats and the placement of scFv can influence the expression dramatically, while discovering that interface stability for heterodimeric constructs is equally important.
The Pharma Data
MAY 13, 2021
Fructose Containing Sugars at Normal Levels of Consumption Do Not Effect Adversely Components of the Metabolic Syndrome and Risk Factors for Cardiovascular Disease. Fructose-containing sugars, blood pressure, and cardiometabolic risk: a critical review. Aspartame bioassay findings portend human cancer hazards. Arq Gastroenterol.
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