The Pharma Data

JANUARY 3, 2021

Nanoform’s capabilities span the small to large molecule development space and the company focuses on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications. Certified Adviser: Danske Bank A/S, Finland Branch, +358 40 562 1806. For more information please visit [link].

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The Pharma Data

JANUARY 20, 2021

In addition to its potent local effect, another advantage of using this active substance is that it has very low bioavailability, i.e. around 90% of it is inactivated in the liver before it reaches the systemic circulation. Forward-Looking Statements. This information was brought to you by Cision [link].

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Drug Discovery World

AUGUST 3, 2022

Oligonucleotides act on the RNA level through different molecular pathways, but there is a major drawback when using them as drugs: their poor bioavailability and cellular uptake. These peptides typically contain up to 30 amino acids and can be cationic, amphipathic or both. These considerations limit their application as therapeutics.

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The Pharma Data

NOVEMBER 26, 2020

Nanoform’s capabilities span the small to large molecule development space and the company focuses on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications. Certified Adviser: Danske Bank A/S, Finland Branch, +358 40 562 1806. For more information please visit [link].

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The Pharma Data

DECEMBER 8, 2020

Kura’s most advanced drug candidate is tipifarnib, a potent, selective and orally bioavailable farnesyl transferase inhibitor currently in a registration-directed trial (AIM-HN) in patients with recurrent or metastatic HRAS mutant head and neck squamous cell carcinoma. Forward-Looking Statements.

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The Pharma Data

NOVEMBER 19, 2020

These compounds have demonstrated high potency in inhibiting the activity of the M pro protease as well as promising oral bioavailability and blood plasma levels in animal studies. This press release contains forward-looking statements, including statements about the discovery, development and commercialization of products.

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The Pharma Data

OCTOBER 21, 2020

We designed KB-0742 to be an orally bioavailable CDK9 inhibitor with a differentiated selectivity profile,” said Norbert Bischofberger, Ph.D., Forward-Looking Statements This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

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Camargo

AUGUST 22, 2021

The FDA also issued the Study Data Technical Conformance Guide , which contains detailed information on how to meet the requirements contained in the DSC. 3.1.1: Bioavailability Study Reports. 3.1.1: Bioavailability Study Reports. Where Are the Technical Rejection Criteria for Study Data Applied? Validation Code.

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The Pharma Data

DECEMBER 3, 2020

Maribavir, an orally bioavailable anti-CMV compound, is the only antiviral agent presently in Phase 3 development for the treatment of post-transplant patients with CMV in SOT or HSCT. In transplant recipients, reactivation of CMV can lead to serious consequences including loss of the transplanted organ and, in extreme cases, can be fatal.

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Pharmaceutical Technology

NOVEMBER 24, 2022

Given our expertise in the provision of IVMT studies to investigate the absolute bioavailability of oral drug molecules, we have developed a particular focus in recent years on the conduct of integrated IVMT/ADME studies. What makes Quotient Sciences’ approach to these study types unique?

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Drug Discovery World

DECEMBER 7, 2022

Different polymorphs of the same active pharmaceutical ingredient (API) can have profound effects on solubility, permeability, and bioavailability, as well as manufacturability. Different crystalline structures mean that these polymorphs will very likely have different properties such as bioavailability and solubility.

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Pharmaceutical Technology

AUGUST 3, 2022

Milling is a central part of powder processing, as this is where coarse particles are broken down into smaller ones for a variety of processability, bioavailability, reactivity, and safety-related reasons. The pharmaceutical industry is certainly no stranger to the unique challenges posed by their process development.

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Drug Discovery World

OCTOBER 25, 2023

It contains structure-related data for more than 3 million compounds, over 5000 unique animal and human validation datasets, and physiological parameters of 196 different subject populations (different species, gender, strain, sub-strain) and counting.

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Pharmaceutical Technology

MAY 10, 2023

Within the pharmaceutical industry, it is critical to measure particle size as it influences surface area and porosity, impacting a drug’s bioavailability, effectiveness, and shelf life. Alternatively, they can come as a product component of formulations such as cleaning agents and polymers.

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The Pharma Data

MAY 14, 2021

The natural green tea contained by this formula, and the broccoli leaf extracts are also powerful ingredients. The Journal of Synthetic Chemistry confirms that broccoli leaf extracts have extremely powerful and valuable nutrients, ones that are required to maintain the good health of the prostate.

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FDA Law Blog

JANUARY 23, 2023

This subsection requires sponsors of any phase 3 or other pivotal drug study (other than bioavailability or bioequivalence studies) to submit diversity action plans by the time they submit the study protocol. Clinical Trial Diversity Under FDORA FDORA adds subsection 505(z) to the Food, Drug, and Cosmetic Act (FDC Act).

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The Pharma Data

JANUARY 27, 2021

Each study is planned to be carried out over an approximately two-week period as an open label, randomized, crossover, two-period, two-sequence, single dose pilot study to assess the relative bioavailability of each product.

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Drug Discovery World

AUGUST 12, 2022

These can have better properties than their parents, including preferable stability, solubility, bioavailability, and manufacturability. Some 5% of commercially available research compounds aresold as salt forms. This can have devastating experimental consequences. Suppose you want to makeup a 0.1

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The Pharma Data

NOVEMBER 17, 2020

The strong results from this Phase 1 readout reinforce our view that LYT-100 has the potential to offer a tolerability and bioavailability profile that could be highly differentiated at the same exposure levels as pirfenidone,” said Daphne Zohar, co-founder and chief executive officer of PureTech. Forward Looking Statement.

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The Pharma Data

MAY 16, 2021

Contains a unique “living chemistry” that was poorly understood until recently…. We’ll start with all-natural food #1 which contains powerful compounds that…. Because this food also contains a mineral that’s proven to help men over 45 burn fat, build muscle, and bound with energy…. Because the next ingredient contains….

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Pharmaceutical Technology

APRIL 12, 2023

Containment and controlled substance capabilities are defining and necessary features for these manufacturing facilities, but not all contract manufacturers have the specialist equipment and capabilities required for high potency small molecule API production.

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Pharmaceutical Technology

MARCH 7, 2023

Safety issues must also be addressed, such as containment and potential ignition factors. Frewitt’s expertise also includes solutions to the API containment space, with both rigid and flexible isolators. The team required narrow nanoparticle size distribution with a short processing time and a stable low temperature milling profile.

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Pharmaceutical Technology

JUNE 14, 2023

This, coupled with small pharma companies being unable to acquire or access containment capabilities in-house, means that the demand for innovative specialized small molecule capabilities remains high. Premium specialized equipment is necessary because high containment facilities call for the separation of the operator from the product.

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Pharmaceutical Technology

FEBRUARY 3, 2023

Additionally, OSD manufacturing approaches are well developed, with processes that ensure a repeatable distribution of ingredients, uniformity in dissolution, and bioavailability, which verify that the drug product is safe and effective.

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