Cardiology and Genomics - Clinical Research Informer

New statement provides path to include ethnicity, ancestry, race in genomic research

Scienmag

JULY 26, 2021

American Heart Association Scientific Statement DALLAS, July 26, 2021 — Genomic studies have produced advances in how to calculate and reduce heart-disease risk, however, the benefits don’t necessarily apply to people from historically marginalized racial and ethnic groups and Indigenous populations.

Genome

Genome Genomics Research Cardiology

Weill Cornell Medicine, NewYork-Presbyterian Hospital, and Illumina collaborate on scalable clinical whole-genome sequencing initiative

Scienmag

DECEMBER 3, 2020

Associated collaboration with the New York Genome Center to expand patient access to advanced genomic technologies Seeking to advance the scope of precision medicine, Weill Cornell Medicine, NewYork-Presbyterian Hospital, and Illumina, Inc.

Genome

Genome Genomics Medicine Genetics

Hypertensive disorders in pregnancy correlated with a higher risk of coronary artery disease and stroke

Medical Xpress

FEBRUARY 22, 2023

Genomic analysis by researchers from the UK and the Netherlands has found links between hypertensive disorders in pregnancy (HDPs) and a higher risk of coronary artery disease and stroke.

Genome

Genome Genomics Research Cardiology

How Phosphorus’ GeneCompass Preventative Genetic Test Can Help People Manage Their Health

XTalks

JULY 19, 2021

Phosphorus, a leading preventative genomics company, has developed the first comprehensive preventative genetic test for consumers. Like other consumer genomic tests, the Phosphorus GeneCompass test also involves the collection of saliva samples that consumers send to the Phosphorus lab located in Secaucus, NJ for analysis.

Genetics

Genetics Genome Genomics Gene

Teens knowing results of their cardiomyopathy genetic tests may improve family function

Scienmag

JULY 13, 2021

Circulation: Genomic and Precision Medicine Journal Report DALLAS, July 13, 2021 — Sharing the results of genetic testing for cardiomyopathy in adolescents ages 13-18 does not appear to cause emotional harm to families or adversely impact family function or dynamics, according to new research published today in Circulation: Genomic and Precision (..)

Genetics

Genetics Genome Genomics Medicine

Using CRISPR-Cas9 as an intervention to protect the heart from ischemia-reperfusion damage

Medical Xpress

JANUARY 20, 2023

In their paper published in the journal Science, the group describes using the gene editing system to modify two bases in the mouse genome to prevent hyperactivation of a protein that can lead to heart disease.

Gene Editing

Gene Editing Genome Genomics Gene

Listen: CRISPR for the heart, biotech’s recovery, & what it means to be a ‘hot girl’

STAT News

JULY 14, 2022

Sek Kathiresan, cardiologist and CEO of Verve Therapeutics, joins us to explain the company’s work on preventing heart disease with genome editing. We cover all that and more this week on “The Readout LOUD,” STAT’s biotech podcast.

Life Science

Life Science Genome Genomics Cardiology

Allelica’s polygenic risk score data published in Circulation

Scienmag

MARCH 8, 2021

Identifies people at high risk of heart attack despite average LDL cholesterol levels Rome, Italy, March 8, 2021 – Allelica, a leading genomics software company specialising in developing polygenic risk scores (PRS) for personalised medicine, today announced publication of a study in Circulation (Vol.

Genome

Genome Genomics Medicine Development

Genetic background influences disease risk from single-gene variants

Scienmag

AUGUST 20, 2020

In people with a single-gene variant that puts them at high risk for heart disease, breast cancer, or colorectal cancer, the rest of the genome can alter that risk Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can […]. (..)

Genetics

Genetics Gene Genome Genomics

HFpEF vs. HFrEF: How To Improve Heart Failure Drug Development

XTalks

APRIL 15, 2021

New advances in heart failure genomics are helping to address this challenge. Experts from Servier and Genuity Science recently spoke on a webinar about using genomics data to drive drug development in heart failure and identify new targets for novel therapeutics. Watch this on-demand webinar to hear from these experts.

Development

Development Drugs Genome Genomics

AstraZeneca to Acquire Alexion, Accelerating the Company’s Strategic and Financial Development

The Pharma Data

DECEMBER 12, 2020

AstraZeneca has developed a broad range of technologies, initially focused on small molecules and biologics and with a growing focus in precision medicine, genomics, oligonucleotides and epigenetics. More recently, AstraZeneca has increased its efforts in immunology research and the development of medicines for immune-mediated diseases.

Development

Development Regulation Medicine Containment

Large Babies Could Be at Risk for Later Atrial Fibrillation

The Pharma Data

OCTOBER 28, 2020

28, 2020 — There may be a positive causal relationship between elevated birth weight and risk for future atrial fibrillation in adulthood, according to a study presented at the annual Great Wall International Congress of Cardiology, held virtually from Oct. The genome-wide association study included 321,223 individuals.

Cardiology

Cardiology Genetics Genome Genomics

Cardiac Biomarkers in Cardiovascular Clinical Trials: Caveats and Considerations

XTalks

NOVEMBER 19, 2021

This is a part of the precision cardiology approach and could lead to their use as prognostic indicators. Dr. Januzzi describes a “biomarker Phase II,” which involves applying an unbiased inductive approach using omics-based approaches, such as proteomics, metabolomics, genomics and transcriptomics, to identify plausible drug-marker pairs.

Clinical Trials

Clinical Trials Clinical Trials Trials In-Vitro

Clinical Research Informer

New statement provides path to include ethnicity, ancestry, race in genomic research

Weill Cornell Medicine, NewYork-Presbyterian Hospital, and Illumina collaborate on scalable clinical whole-genome sequencing initiative

Trending Sources

Hypertensive disorders in pregnancy correlated with a higher risk of coronary artery disease and stroke

How Phosphorus’ GeneCompass Preventative Genetic Test Can Help People Manage Their Health

Teens knowing results of their cardiomyopathy genetic tests may improve family function

Using CRISPR-Cas9 as an intervention to protect the heart from ischemia-reperfusion damage

Listen: CRISPR for the heart, biotech’s recovery, & what it means to be a ‘hot girl’

Allelica’s polygenic risk score data published in Circulation

Genetic background influences disease risk from single-gene variants

HFpEF vs. HFrEF: How To Improve Heart Failure Drug Development

AstraZeneca to Acquire Alexion, Accelerating the Company’s Strategic and Financial Development

Large Babies Could Be at Risk for Later Atrial Fibrillation

Cardiac Biomarkers in Cardiovascular Clinical Trials: Caveats and Considerations

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