Worldwide Clinical Trials

FEBRUARY 6, 2023

When using genetic screening to identify clinical trial volunteers, a sponsor’s obligations for further testing and disclosure of results to patients and families are unclear, especially when the results have no impact on medical management. Guidance in this area is much needed.

Genetics 130

Genetics Clinical Trials Clinical Trials Genotype 130

Drug Discovery World

FEBRUARY 27, 2024

While we have made a lot of progress in targeted therapeutics by identifying molecular tumour drivers that define patient subsets, genomics has not quite produced the same level of understanding for tumour-immune biology. Ron A : One of the most important problems to solve in drug discovery is improving the probability of clinical success.

Genome 52

Genome Genomics Genotype Medicine 52

XTalks

APRIL 24, 2023

For rare disease studies where there is little or no clinical trial experience, outcome assessments would have to be validated within a clinical development program. Early and ongoing engagement with regulators greatly helps clinical development planning.

Gene Therapy 95

Gene Therapy Gene Trials Clinical Trials 95

Drug Discovery World

OCTOBER 30, 2023

RA: You’ve recently announced a collaboration with the University of Oxford to access genotype data on women with endometriosis. We previously conducted a hypothesis-free study using genotype data from the UK Biobank, which resulted in the first mechanism-based stratification of endometriosis patients.

Genome 72

Genome Genomics Genotype Clinical Trials 72