ICON partners with US Government for clinical trials of Covid-19 vaccines
Pharmaceutical Technology
SEPTEMBER 14, 2023
ICON will conduct Phase IIb clinical trials for the US BARDA-selected Covid-19 vaccine candidates as part of ‘Project NextGen’.
Successful clinical trial for re-engineered Covid vaccine
Drug Discovery World
NOVEMBER 24, 2023
The University of Queensland’s re-engineered clamp platform has produced a vaccine that is equally safe and virus-neutralising as an approved Covid vaccine considered among the best in its class. The Clamp2 trial group showed a 2.5-fold fold boost in neutralising ‘titres’ and it was 2.1 in the Novavax group.
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HIV vaccine being developed by Johnson & Johnson fails clinical trial
STAT News
JANUARY 18, 2023
Yet another experimental HIV vaccine has failed. The National Institute of Allergy and Infectious Diseases reported Wednesday that a Phase 3 clinical trial of a vaccine was stopped because the vaccine was ineffective at preventing HIV infection. Read the rest…
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“Game-changing” personalised cancer vaccine enters UK clinical trials
Drug Discovery World
APRIL 26, 2024
A clinical trial of a personalised mRNA cancer vaccine for melanoma patients has been launched in the UK. The vaccines are personalised to each patient after a tumour sample is removed during surgery and then analysed using DNA sequencing. in the combination arm and 62.2%
Pfizer, after delay, completes enrollment in Lyme vaccine trial
Bio Pharma Dive
DECEMBER 5, 2023
The announcement ends a lengthy setback that began when the company and partner Valneva accused a clinical trial site operator of study misconduct.
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Naobios manufactures FluGen Inc’s M2SR influenza vaccine candidate for upcoming clinical trials
Pharma Mirror
SEPTEMBER 22, 2021
Nantes, France, Naobios, a CDMO (Contract Development and Manufacturing Organization) providing bioprocess development and GMP production of clinical batches of viral vaccines BSL2/BSL3, oncolytic viruses and viral vectors, today announces the next phase in its partnership with FluGen, Inc., The company’s.
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Pharma Mirror Q&A with Jane Myles, Vice President of Clinical Trial Innovation at Curebase
Pharma Mirror
JANUARY 23, 2023
This webinar focused on the need for a coordinated clinical trials enterprise, one that can quickly characterize emerging viral threats and evaluate the effectiveness of vaccines, therapeutics, and other countermeasures across a diversity of trial participants.
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Velocity Wins the 2024 Vaccine Industry Excellence Award for Best Clinical Trial Company
Velocity Clinical Research
APRIL 3, 2024
Velocity has won the 2024 Vaccine Industry Excellence (ViE) award for Best Clinical Trial Company at The World Vaccine Congress in Washington, DC. The recognition is based on performance metrics, diversity of vaccine trial capabilities, and key initiatives to support vaccine research. and Europe.
New cancer drug clinical trials struggling
World of DTC Marketing
OCTOBER 6, 2020
WHAT’S THIS ABOUT THEN : Researchers are rushing to launch clinical trials of experimental vaccines against the coronavirus, and treatments for COVID-19. Eli Lilly recently announced that it would halt enrolment in ongoing studies and delay the launch of new trials.
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Clinical trial will test novel inhaled TB vaccine
Drug Discovery World
JANUARY 16, 2024
A new study will compare whether giving tuberculosis vaccine by inhalation is better at protecting against tuberculosis (TB) than injection into the skin. The Jenner Institute at the University of Oxford is conducting the study using Bacille Calmette-Guérin (BCG), the current licensed vaccine against TB.
Moderna takes HIV trimer mRNA vaccine into clinical trials
BioPharma Reporter
MARCH 14, 2022
The first participant has been dosed in a Phase 1 clinical trial of HIV trimer mRNA vaccine candidate mRNA-1574.
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BioNTech targets infectious diseases for vaccine development
Pharmaceutical Technology
MARCH 28, 2023
Following on from its Covid-19 vaccine programmes, BioNTech has set its sights on a range of infectious diseases for vaccine development. The company saw major successes with its Covid-19 vaccine, developed in collaboration with Pfizer. In response to the lower vaccine sales forecasts, BioNTech shares opened at 3.9%
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Personalized mRNA vaccine to treat aggressive pancreatic cancer in clinical trial
Medical Xpress
MAY 11, 2023
A large team of medical researchers at Memorial Sloan Kettering Cancer Center, in New York, working with colleagues from the Icahn School of Medicine at Mount Sinai and German firm BioNTech has developed a personalized mRNA vaccine that shows promise against an aggressive form of pancreatic cancer in clinical trial results.
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Enhancement, Efficiency, Equity, and Engagement: Four Trends Shaping Clinical Trials in 2024
ACRP blog
JANUARY 3, 2024
Historically, patient recruitment and retention have been pressing issues within the clinical trial space. Eighty-five percent of trials fail to recruit enough patients, while 80% are delayed due to other factors like participant dropouts.
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Moderna to Launch Clinical Trials for mRNA-Based HIV Vaccine
BioSpace
AUGUST 16, 2021
Moderna is expected to launch a human clinical trial as early as this week for an mRNA-based vaccine against HIV and indicated that it is looking for 56 people ages 18 to 50 who are HIV-negative.
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The next phase of decentralisation in clinical trials
Pharmaceutical Technology
APRIL 20, 2023
The face of clinical research is evolving. Rather than bringing patients to sites, study teams are now exploring ways they can bring the trial to patients using a varying combination of direct-to-patient drug shipments, home nursing, video conferencing, and electronic data collection. Everybody got used to doing things remotely.
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GSK sets high bar with trial results for RSV vaccine
Bio Pharma Dive
OCTOBER 13, 2022
With data expected for several other vaccines for the respiratory disease, GSK reported positive clinical trial results showing efficacy above 80%.
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Why Is CVS Health Clinical Trial Services Closing?
XTalks
MAY 24, 2023
Leading health solutions company CVS Health recently disclosed that its clinical trial business will shut down just two years after its initiation in May 2021. The company will gradually wind down its CVS Health Clinical Trial Services unit with full exit by December 31, 2024.
Partnership to execute next generation Covid-19 vaccines clinical trial
Drug Discovery World
SEPTEMBER 18, 2023
Next generation Covid-19 vaccines could have the potential to expand the breadth of coverage against existing and future variants of the virus, extend the duration of protection, and offer better protection in the prevention of illness and transmission over the current state of vaccine technologies.
Improving Black Participation in Clinical Trials: Bridging the Gap
XTalks
FEBRUARY 21, 2024
Black participation in clinical trials, and the underrepresentation of minority groups in general in trials, remains low. It is therefore important to work towards increasing Black participation in clinical trials, which begins with understanding the barriers to participation and taking steps to address them.
Vaxart's oral COVID-19 tablet vaccine to enter clinical trials
BioPharma Reporter
SEPTEMBER 15, 2020
Vaxart will start a Phase 1 clinical trial for its oral COVID-19 vaccine candidate, having received Investigational New Drug (IND) clearance.
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Breaking Down Barriers to International Clinical Trials
ACRP blog
MARCH 12, 2024
Global Disruptions, Health Equity, and Data Sharing International clinical trials are essential to evaluating the safety and efficacy of new treatments, but their success can be hampered by a variety of challenges. Additionally, how do you ensure that the vaccine distribution is equitable?
10 Trends and Statistics for Clinical Trials in 2023
XTalks
MAY 19, 2023
Clinical trials play a vital role in advancing patient treatment and medical care. This article delves into ten trends and statistics in the world of clinical trials for 2023. Increasing Number of Registered Clinical Trials As of May 17, 2023, there are 452,604 registered clinical trials globally on ClinicalTrials.gov.
BioNTech to take malaria vaccine into clinical trials later this year
BioPharma Reporter
JULY 12, 2022
BioNTech is readying to take its mRNA malaria vaccine candidates into clinical trials later this year.
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CyanVac starts Phase 1 clinical trial for intranasal COVID-19 vaccine
BioPharma Reporter
SEPTEMBER 27, 2021
have enrolled the first participant in a Phase 1 clinical trial of their intranasal COVID-19 vaccine in Rochester, NY. CyanVac LLC and its subsidiary, Blue Lake Biotechnology, Inc.,
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mRNA universal influenza vaccine enters clinical trials
Drug Discovery World
MAY 18, 2023
A clinical trial of an experimental universal influenza vaccine developed by researchers at the National Institute of Allergy and Infectious Diseases’ (NIAID) Vaccine Research Center (VRC) has begun enrolling volunteers at Duke University in Durham, North Carolina.
UK scientists prepare for Nipah virus clinical trial
Drug Discovery World
SEPTEMBER 19, 2023
The University of Oxford has revealed that researchers are currently in the advanced stages of preparing for a clinical trial of a Nipah vaccine using the ChAdOx1 vector. There are currently no approved vaccines or treatments for Nipah virus infection. Seasonal outbreaks have occurred annually in Bangladesh since 2001.
Brazil’s ANVISA approves Takeda’s dengue vaccine candidate Qdenga
Pharmaceutical Technology
MARCH 14, 2023
The National Health Surveillance Agency (ANVISA) in Brazil has granted approval for Takeda ’s dengue virus vaccine candidate, Qdenga (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003). The vaccine has received approval for preventing dengue disease in people aged four years to 60 years.
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Clinical Trial Trends & Insights 2024
WCG Clinical
JANUARY 4, 2024
Download report Intelligently Connecting Data and Insight to Navigate the Clinical Research Trends of Tomorrow Advancing health is all about connections. Connecting people, data, insights, and technology for a better, more efficient clinical trial experience. Despite this improvement, disconnects remain.
NIH clinical trial for universal influenza vaccine begins
Pharma Times
SEPTEMBER 20, 2023
The universal vaccine could protect people against more strains of flu - News - PharmaTimes
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Clinical trial set to test efficacy of mixing Sputnik V and COVID-19 Vaccine AstraZeneca
BioPharma Reporter
FEBRUARY 9, 2021
Health officials in Azerbaijan have granted approval for a clinical trial to take place in that country combining Russiaâs Sputnik V vaccine with the Oxford-AstraZeneca COVID-19 shot in adults 18 years and older.
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Preparing for the Future of Clinical Trials
ACRP blog
MARCH 23, 2023
Generating evidence by integrating research into patient care Clinical trials are increasingly using longitudinal evidence generation, where repeated measurements are taken over time from the same set of patients. This is leading to changes in expectations of how research sites carry out trials.
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Clinical Trials for Celiac Disease: Insights from Beyond Celiac’s Kate Avery
XTalks
MAY 4, 2023
However, there are ongoing clinical trials for celiac disease to investigate potential new treatments. Overall, the state of clinical trials for celiac disease is promising, as researchers are actively working to develop new treatments that could help improve the lives of people with the condition.
How Does Site Location Impact Patient Diversity in Clinical Trials?
Velocity Clinical Research
APRIL 5, 2024
Velocity recently asked some key employees to come together and discuss a wide array of issues impacting diversity, equity, and inclusion (DEI) in clinical trials. At its core, Velocity’s strategy is to put sites in locations to best advance diversity in clinical trials. she said.
PI Focus: Building Relationships Through Clinical Trials in the United Kingdom
Velocity Clinical Research
JULY 18, 2023
Born and trained in Egypt, he moved to the UK several years ago after working as a general practitioner there and deciding he loved the country and the clinical trial opportunities it offered. Mutiah, originally from India, moved to the UK and became a study coordinator in 2014. By 2018, she was directing seven sites.
Investigation raises concerns about poor FDA oversight of clinical trials
Medical Xpress
NOVEMBER 16, 2022
COVID-19 vaccines and drugs were developed at "warp speed" and now experts are concerned about the US Food and Drug Administration's (FDA) inadequate surveillance of clinical trial sites, reports an investigation published by The BMJ today.
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Breakthrough Vaccine Shows High Protection Against Drug-Resistant Superbug in Mice
AuroBlog - Aurous Healthcare Clinical Trials blog
MAY 1, 2024
Scientists have developed a vaccine against a notorious drug-resistant superbug, targeting molecules on its surface that are also found on other bacteria and fungi.
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Sanofi and GSK begin clinical trials of coronavirus vaccine
pharmaphorum
SEPTEMBER 4, 2020
Sanofi and GlaxoSmithKline have begun clinical trials of their coronavirus vaccine, as AstraZeneca expanded studies of its rival into Japan. The French pharma in April joined forces with the UK’s GSK to produce the vaccine, with Sanofi contributing an antigen that produces the immune reaction.
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Experimental Alzheimer’s Vaccine Shown to Delay Symptoms in Mice
AuroBlog - Aurous Healthcare Clinical Trials blog
AUGUST 3, 2023
An experimental vaccine that aims to slow down or prevent the progression of Alzheimer’s disease has been trialed in mice with promising early results. Mice engineered with genes that put them at greater risk of an Alzheimer’s-like disease had fewer amyloid plaques following the vaccine.
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Celebrating the Critical Role of Clinical Trials in Advancing Human and Public Health
ACRP blog
MAY 16, 2023
Clinical trials have been the foundation of medical research for almost 250 years. James Lind, a Scottish naval surgeon and physician, is widely credited with performing the first comparative clinical trial. For that reason, every May 20 we proudly join the scientific community in celebrating Clinical Trials Day.
CMV Vaccine Trials: Moderna’s CMV mRNA Vaccine Enters Phase III
XTalks
FEBRUARY 19, 2024
Moderna has been testing an experimental mRNA vaccine aimed at combating the human cytomegalovirus (CMV), which poses significant health risks to newborns and immunocompromised patients. The team used the data and patient samples from a gB/MF59 Phase II trial in adolescent girls as a benchmark to assess the new mRNA-based vaccine.
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UK partners with BioNTech on clinical trials of mRNA cancer therapies
pharmaphorum
JANUARY 6, 2023
The UK has formed an partnership with German biotech BioNTech to provide up to 10,000 patients with access to personalised cancer therapies, in another example of the country embracing the mRNA technologies that underpinned COVID-19 vaccines. The post UK partners with BioNTech on clinical trials of mRNA cancer therapies appeared first on.
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Malaria Could Be Eliminated by 2040: New Vaccine Offers Hope
AuroBlog - Aurous Healthcare Clinical Trials blog
OCTOBER 8, 2023
The World Health Organization has approved a new vaccine that scientists argue will be a game-changer in the fight against malaria, which kills half a million people in Africa every year.
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India grants approval for Bharat Biotech’s intranasal Covid-19 vaccine
Pharmaceutical Technology
SEPTEMBER 7, 2022
Indian company Bharat Biotech International has secured approval from Central Drugs Standard Control Organisation (CDSCO) under Restricted Use in Emergency Situation for its intranasal Covid-19 vaccine, iNCOVACC (BBV154), for usage in people aged 18 years and older. It is formulated to permit intranasal delivery via nasal drops.
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