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Unlocking the potential of mRNA for the future treatment of rare diseases 

Drug Discovery World

At this stage, qPCR can be used to check for IVT efficiency, residual DNA contamination and adventitious agents such as microbes. The identity of the transcript is confirmed by Sanger sequencing.

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Biopharmaceutical Filtration: A Deep Dive

Roots Analysis

It involves the separation of unwanted particles from biological materials to obtain contaminant free products. Biopharmaceutical filtration systems are designed to remove impurities and contaminants, to improve safety, purity and shelf life of the product. Particle Removal: This is the primary function of these filtration systems.

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Risk Assessment for use of Engineered Genetic Materials in Clinical Research

Advarra

Gene Delivery Systems Genetic material, in the form of DNA or RNA, does not easily enter cells without the aid of a delivery system. For example, the Pfizer and Moderna mRNA COVID vaccines utilize lipid nanoparticles, while other approaches utilize genetically engineered viruses.

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The Utility of Liquid Biopsy in Oncology Clinical Trials

XTalks

Liquid biopsy tests in oncology involve isolating entities such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and tumor-derived exosomes. However, Dr. Bahassi reported that the selection of CTCs using this method is often not very efficient and the CTC population is usually highly contaminated with leukocytes.

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Improving quality control for CAR T cell therapies

Drug Discovery World

Although this type of contamination has not yet been reported in humans, RCVs can form rapidly growing T cell neoplasms, another type of cancer. How ddPCR technology detects and quantifies DNA ddPCR technology is a highly sensitive and accurate tool used to detect and quantify known genetic sequences. Frontiers in Immunolology.

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COVID-19 Pandemic Coverage

XTalks

The company’s candidate vaccine, mRNA-1273, is a synthetic messenger RNA that encodes the stabilized SARS-CoV-2 spike protein. Unlike COVID-19 tests that need to be processed through PCR machines, the new rapid test is processed through a handheld DNA analyzer. Fujifilm Favipiravir (Avigan) Inhibits RNA-dependent RNA polymerase.