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8 Frequently Asked Questions About Genetic Testing in Clinical Trials

Worldwide Clinical Trials

Genetic testing provides patients with a diagnosis for their illness, helps patients and family members to understand risks of developing new diseases, and can be used to support clinical trial advancement. What are the benefits and limitations to using genetic testing?

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Why early participant engagement is now a top priority in genetic disease research

pharmaphorum

In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. First, start co-development with participants early on in the process.

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Osimertinib Resistance and EGFR Mutations in NSCLC Treatment

Bioengineer

Analysis of circulating tumor (ct) DNA at the time of treatment discontinuation or progression showed that 49% of patients in the AURA3 trial lacked the T790M mutation. Often, the loss of T790M is associated with the development of alternative competitive resistance mechanisms.

Genome 119
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Why a recent advancement is a giant leap for human genomics

Drug Discovery World

The remaining 8% of the genome was often referred to as the dark matter of the genome or sometimes even ‘Junk DNA’ 2. The Telomere-to-Telomere (T2T) Consortium successfully sequenced about 200 million remaining base pairs to approach 100% of the human genome by using the newly developed long read sequencing (LRS) technology 3,4,5.

Genome 52
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Nutrigenomics: The Future of Personalized Nutrition

Roots Analysis

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. Nutritional DNA testing helps in identifying foods that might lead to allergies or intolerance in an individual.

Genome 40
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Biorepositories as a Guiding Resource for Research & Drug Discovery

XTalks

Data generated through high-throughput omics approaches paired with clinical patient records can give rise to remarkably robust datasets to inform and guide disease insights and development of targeted therapeutics. Genomic biomarker discovery helps drive the development of innovative new personalized therapies. Biobanking Models.

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New HIV variant highlights the importance of monitoring virus mutations

pharmaphorum

Researchers discovered a highly virulent variant of HIV in the Netherlands that genetic sequence analysis suggests has been circulating since the 1990s. . Identified as the “VB variant,” the virus has proved to be highly virulent and to speed up the progression of a patient developing AIDS faster. Effects of the variant.

Genome 98