Osimertinib Resistance and EGFR Mutations in NSCLC Treatment
Bioengineer
JANUARY 16, 2024
This mutation hinders the drug’s binding to the mutant EGFR protein. Osimertinib, however, can covalently bind to the T790M and cysteine-797 (C797) residue at the protein’s ATP binding site, overcoming resistance mechanisms. T790M loss has been linked to earlier resistance and poorer survival in other cohorts.
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