Fri.Jan 07, 2022

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As three biotechs head to Wall Street, a battered sector braces for a pullback

Bio Pharma Dive

Amylyx, CinCor and Vigil raised about $480 million combined, a sign of continued investor interest in biotech IPOs. But industry analysts expect fewer and smaller offerings in 2022 due to investor fatigue from high valuations.

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Good Rx? Actually not

World of DTC Marketing

GoodRx promotes itself as a company that allows you to compare drug prices and find coupons at over 60,000 pharmacies across the country, but actually, most pharmacists hate it. When they say compare prescription drug prices, they mean the cost of a prescription if you aren’t using insurance. And advertising? Uh, no. GoodRx makes money in two main ways: Advertisements on their site and a percentage fee every time a GoodRx coupon is used at the pharmacy.

Pharmacy 222
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AstraZeneca adds to rare disease drug pipeline with Neurimmune deal

Bio Pharma Dive

Neurimmune, which will license to AstraZeneca an early-stage treatment for a rare form of cardiomyopathy, is probably best known for its invention of the antibody that became Biogen's Alzheimer's drug Aduhelm.

Drugs 281
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AstraZeneca goes bigger in amyloidosis with Neurimmune deal

pharmaphorum

AstraZeneca has clearly made the rare disease transthyretin amyloidosis (ATTR) a key component of its rare disease pipeline, licensing a second drug candidate in the space of a couple of months. In the latest deal, the pharma group is paying $30 million upfront with another $730 million in milestone’s for global rights to Neurimmune’s NI006, a drug in early-stage clinical for cardiomyopathy, a progressive and fatal complication affecting some patients with ATTR.

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Cancer Blood Test Developed by University of Oxford Researchers Can Detect Metastasis

XTalks

Researchers at the University of Oxford have developed a blood test for the detection of different cancers, and the test can also determine whether a cancer has metastasized. Additionally, the cancer blood test can spot disease in patients that have non-specific symptoms and can help clinicians determine the stage of a cancer. The test is based on the measurement of cancer-associated metabolite biomarkers in the blood using nuclear magnetic resonance (NMR) spectroscopy.

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Putting patient perspectives at the heart of kidney cancer research

pharmaphorum

Kidney cancer is the 14 th most common cancer, with approximately 400,000 new cases worldwide every year. Renal cell carcinoma (RCC) is by far the most prevalent type of cancer originating from the kidney, making up nine out of ten kidney cancer diagnoses. As chief medical officer, head of global medical affairs, patient safety and patient affairs – putting patient interests first is central to my role and values.

Research 105

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Another big AI deal as Sanofi taps Exscientia for 15 new drugs

pharmaphorum

If the last couple of days is an indication, 2022 is already shaping up to be the year of big-ticket alliances between big pharma companies and specialists in artificial intelligence-driven discovery. Shortly after Amgen unveiled its $1.9 billion alliance with Generate Biomedicines aimed initially at five drug molecules, Sanofi has announced a big expansion of its longstanding partnership with Exscientia that covers no fewer than 15 programmes.

Drugs 102
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Researchers develop first fully 3D-printed, flexible OLED display

Scienmag

MINNEAPOLIS / ST. PAUL (01/07/2022) — In a groundbreaking new study, researchers at the University of Minnesota Twin Cities used a customized printer to fully 3D print a flexible organic light-emitting diode (OLED) display. The discovery could result in low-cost OLED displays in the future that could be widely produced using 3D printers by anyone at home, […].

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Exscientia and Sanofi collaborate to develop AI-driven precision-engineered medicines

Pharma Times

The platform integrates primary human tissue samples into early target and drug discovery research.

Engineer 114
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Chang’E-5 lander makes first onsite detection of water on moon

Scienmag

A joint research team led by Profs. LIN Yangting and LIN Honglei from the Institute of Geology and Geophysics of the Chinese Academy of Sciences (IGGCAS) observed water signals in reflectance spectral data from the lunar surface acquired by the Chang’E-5 lander, providing the first evidence of in-situ detection of water on the Moon. Credit: […].

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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NICE recommends MSD’s Keytruda in combination with chemotherapy for routine treatment of lung cancer

Pharma Times

With over 48,000 new cases diagnosed per year, lung cancer is the third most common cancer in the UK.

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Blood test helps predict who may benefit from lung cancer screening

Scienmag

HOUSTON ? A blood test, combined with a risk model based on an individual’s history, more accurately determines who is likely to benefit from lung cancer screening than the current U.S. recommendation, according to a study published today in the Journal of Clinical Oncology led by researchers from The University of Texas MD Anderson Cancer […].

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New patent for Antares Pharma drug XYOSTED (AUTOINJECTOR)

Drug Patent Watch

Annual Drug Patent Expirations for XYOSTED+%28AUTOINJECTOR%29 Xyosted (autoinjector) is a drug marketed by Antares Pharma Inc and is included in one NDA. It is available from one supplier. There are…. The post New patent for Antares Pharma drug XYOSTED (AUTOINJECTOR) appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 52
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Forecasting capacity degradation of lithium metal batteries using a data-driven approach

Scienmag

With the long-term goal to realize carbon neutrality, lithium battery has acquired a growingly central role in the development of human society. The accurate yet efficient prognosis on battery state of health (SOH) remains vital in ensuring a safe and reliable operation. In addition, as the demand to increase battery energy density continues to grow, […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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New patent for Takeda Pharms drug ICLUSIG

Drug Patent Watch

Annual Drug Patent Expirations for ICLUSIG Iclusig is a drug marketed by Takeda Pharms Usa and is included in one NDA. It is available from one supplier. There are three…. The post New patent for Takeda Pharms drug ICLUSIG appeared first on DrugPatentWatch - Make Better Decisions.

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Study sets framework for precision surveillance of colorectal cancer

Scienmag

A team of Vanderbilt researchers has revealed some of the mechanisms by which polyps develop into colorectal cancer, setting the framework for improved surveillance for the cancer utilizing precision medicine. Credit: Vanderbilt University Medical Center A team of Vanderbilt researchers has revealed some of the mechanisms by which polyps develop into colorectal cancer, setting the […].

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Noodles & Company Debuts Low-Carb, High Protein Linguini

XTalks

Pasta is the latest food to receive a better-for-you makeover with the debut of Noodles & Company’s “LEANguini.” The fast-casual pasta chain claims the new noodle has 56 percent fewer net carbs, 30 percent fewer total carbs and 44 percent more protein than traditional wheat noodles, all while maintaining the same taste and appearance as traditional linguine.

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Researchers aim to improve diabetes management in rural and urban communities with low-cost intervention

Scienmag

Mental time travel — transporting someone from the present through imagining a personal, positive future event — has been proven to help reduce alcohol, tobacco, and drug use. Credit: Virginia Tech Mental time travel — transporting someone from the present through imagining a personal, positive future event — has been proven to help reduce alcohol, […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Durian - the King of fruits for health

Pharma Tutor

Durian - the King of fruits for health. Manisha Choudhary 1 , Rajesh Vagh 2 , MM Abid Ali Khan 3 , Raaz K. Maheshwari* 4. admin. Sat, 01/08/2022 - 11:09. Tags. Articles.

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Biotechnology could provide an environmentally more sustainable alternative to egg white protein production

Scienmag

The research by the Future Sustainable Food Systems research group at the University of Helsinki together with VTT Technical Research Centre of Finland shows that fungus-produced ovalbumin could have the potential to mitigate part of the environmental burden associated with chicken egg white powder. This is especially true when using low carbon energy sources in […].

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Mustang Bio Announces MB-106 CD20-Targeted CAR T Data Selected for Presentation at the 2022 Tandem Meetings I Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR

BioTech 365

Mustang Bio Announces MB-106 CD20-Targeted CAR T Data Selected for Presentation at the 2022 Tandem Meetings I Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR Mustang Bio Announces MB-106 CD20-Targeted CAR T Data Selected for Presentation at the 2022 … Continue reading →

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Life in the “dead” heart of Australia

Scienmag

8 January 2022, Sydney. A team of Australian and international scientists led by Australian Museum (AM) and University of New South Wales (UNSW) palaeontologist Dr Matthew McCurry and Dr Michael Frese of the University of Canberra have discovered and investigated an important new fossil site in New South Wales, Australia, containing superb examples of fossilised […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Immunovant to Present at the 40th Annual J.P. Morgan Healthcare Conference

BioTech 365

Immunovant to Present at the 40th Annual J.P. Morgan Healthcare Conference Immunovant to Present at the 40th Annual J.P. Morgan Healthcare Conference NEW YORK, Jan. 07, 2022 (GLOBE NEWSWIRE) — Immunovant, Inc.

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Budget of dissolved organic carbon in the South China Sea assessed by an eddy-resolving ocean model

Scienmag

Dissolved organic carbon (DOC) is the majority of marine organic carbon. Understanding its source and sink processes is of great significance to global carbon cycle and will provide insights in achieving carbon neutrality. How do different physical and biogeochemical processes interact to contribute to the budgets of DOC and particulate organic carbon (POC)?

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Iovance Biotherapeutics to Present Data on Tumor-Infiltrating Lymphocyte (TIL) Cell Therapy at the 2022 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT™ and CIBMTR®

BioTech 365

Iovance Biotherapeutics to Present Data on Tumor-Infiltrating Lymphocyte (TIL) Cell Therapy at the 2022 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT™ and CIBMTR® Iovance Biotherapeutics to Present Data on Tumor-Infiltrating Lymphocyte (TIL) Cell Therapy at the 2022 … Continue reading →

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Virginia Tech leads team to assess the processes and vulnerabilities of groundwater self governance

Scienmag

Marston leads a multi-institutional team of researchers that was recently awarded a nearly $1.6 million grant by the National Science Foundation to develop new theories of how socio-environment diversity determines the effectiveness, resilience, and adaptability of groundwater self-governance regimes. Their research examines the viability of these regimes under current conditions but also seeks to understand how they […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Intra-Cellular Therapies Announces Closing of $460 Million Public Offering Including Full Exercise of Underwriters’ Option to Purchase Additional Shares

BioTech 365

Intra-Cellular Therapies Announces Closing of $460 Million Public Offering Including Full Exercise of Underwriters’ Option to Purchase Additional Shares Intra-Cellular Therapies Announces Closing of $460 Million Public Offering Including Full Exercise of Underwriters’ Option to Purchase Additional Shares NEW YORK, … Continue reading →

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Eccentric exoplanet discovered

Scienmag

Led by the University of Bern, an international research team has discovered a sub-Neptune exoplanet orbiting a red dwarf star. The discovery was also made thanks to observations performed by the SAINT-EX observatory in Mexico. SAINT-EX is run by a consortium including the Center for Space and Habitability (CSH) at the University of Bern and […].

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Foghorn Therapeutics to Participate at the H.C. Wainwright BioConnect Conference

BioTech 365

Foghorn Therapeutics to Participate at the H.C. Wainwright BioConnect Conference Foghorn Therapeutics to Participate at the H.C. Wainwright BioConnect Conference CAMBRIDGE, Mass., Jan. 07, 2022 (GLOBE NEWSWIRE) — Foghorn® Therapeutics Inc.

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Current marsh pollution has dramatic, negative effects on sea anemone’s survival

Scienmag

WOODS HOLE, Mass. — Stationary marine organisms that don’t ply the ocean, but spend their lives rooted in one spot, have evolved impressive ways to capture prey. The sea anemone Nematostella, for instance, burrows into salt marsh sediments and stays there for life. But it has specialized ‘stinging cells’ that hurl toxins into passing prey, […].

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.