Drug Discovery World

APRIL 12, 2024

The top stories: Genetically engineered dendritic cells enhance lung cancer therapy A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendritic cells directly into cancerous lung tumours can help promote a stronger immune response.

Drugs 52

Drugs Genetic Engineering Immune Response Engineer 52

Scienmag

MARCH 15, 2021

Engineered T cells can recognize and destroy cells with loss of one gene copy Credit: Elizabeth Cook Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers.

Genetics 54

Genetics Immune Response Engineer Gene 54

Pharmaceutical Technology

JUNE 28, 2022

The alliance will utilise the cancer-fighting potential of iADCs as a new modality, along with the expertise of Sutro to engineer complex conjugated antibodies and the global oncology research and development (R&D) capabilities of Astellas. It can potentially enhance the anti-cancer effect.

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Development Antibody Immune Response Production 264

Drug Discovery World

JANUARY 11, 2023

AbbVie and Immunome have agreed a worldwide collaboration with the aim of discovering up to 10 novel antibody-target pairs arising from three specified tumour types using Immunome’s Discovery Engine. . We look forward to utilising their Discovery Engine to enhance our existing oncology pipeline.” .

Antibody 52

Antibody Engineer Immune Response Sales 52

XTalks

AUGUST 8, 2022

The company has developed a proprietary discovery platform called I-ReSToRE ( RE ceptor S election and T argeting t o R einstate immune E quilibrium) that has the potential to support the development of agonist antibodies targeting immune inhibitory receptors to treat inflammatory diseases.

Immune Response 98

Immune Response Antibody Life Science Engineer 98

Drug Discovery World

FEBRUARY 20, 2024

Licensing for human use Adjuvants are components of vaccines that help to enhance the magnitude, breadth, and duration of the immune response to vaccination. Imagine a future where vaccines are not only more affordable but also provide consistent protection in fewer doses, without causing discomfort or requiring refrigeration.”

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Vaccination Vaccine Development Immune Response 52

BioTech 365

OCTOBER 28, 2020

RTX-321 Induces Antigen-Specific Stimulation Combined with Broad Stimulation of Innate and Adaptive Immune Responses CAMBRIDGE, Mass., Nasdaq:RUBY), a clinical-stage biopharmaceutical company that is genetically engineering red blood cells to create an … Continue reading →

Genetic Engineering 40

Genetic Engineering Immune Response Engineer Genetics 40

Pharmaceutical Technology

SEPTEMBER 14, 2022

Successful TIL therapy depends on the infusion product containing tumour-reactive T cells that, on infusion, generate an anti-tumour immune response that causes disease regression. The use of engineered immune cytokines that selectively induce the expansion of TILs is being investigated as an alternative to IL-2 stimulation.

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Immune Response In-Vivo Production Manufacturing 246

Drug Discovery World

NOVEMBER 30, 2022

million to support further development of the re-engineered technology for use in the global response to future disease outbreaks. . Importantly, this re-engineered technology does not pose any issue with diagnostic interference as was encountered in 2020.” . Clamp technology .

Vaccination 52

Vaccination Vaccine Immune Response Engineer 52

BioTech 365

OCTOBER 22, 2020

-Proof-of-concept achieved for VY-UC to engineer donor cells without the complexities of gene-editing -Novel platform abrogates cellular immune response and obviates the need for immunosuppressive drugs TAMPA, Fla. & & STOCKHOLM–(BUSINESS WIRE)–#celltherapy–Vycellix, Inc.,

Gene Editing 52

Gene Editing Immune Response Life Science Engineer 52

The Pharma Data

DECEMBER 17, 2020

Merck will select cancer targets and harness Janux’s proprietary Tumor Activated T Cell Engager (TRACTr) technology to engineer novel, T cell engager drug candidates. Janux technology can be applied to immunotherapies that target all three stages of an anti-tumor immune response.

Immune Response 52

Immune Response Engineer Development Licensing 52

Drug Discovery World

APRIL 11, 2024

We have noted that cancer patients can develop powerful anti-tumour immune responses that can result in complete cure of the disease and we call these patients ‘elite responders’. By understanding what triggers the adaptive immune response in “elite responders” we have identified new targets and therapeutic antibodies.

Research 59

Research Immune Response Antibody Medicine 59

Drug Discovery World

AUGUST 2, 2022

Secondary endpoints will evaluate treatment efficacy, including progression-free and overall survival as well as any immune response to NeuroNova. . NeuroNova is an allogeneic “off-the-shelf” therapy comprised of an immortalised Neural Stem Cell (NSC) line loaded with an engineered oncolytic adenovirus.

Trials 52

Trials Immune Response Clinical Trials Clinical Trials 52

Drug Discovery World

NOVEMBER 16, 2022

They regulate tissue repair and regeneration, organ development, and immune response to disease but remain understudied by biopharma due to low abundance, higher structural complexity, and the massive search space to map secreted proteins to disease-reversing effects in specific target cells across human organs.

Protein 52

Protein Engineer Immune Response Insulin 52

pharmaphorum

FEBRUARY 18, 2021

Researchers from the University of Texas Medical Branch based their findings on lab tests using SARS-CoV-2 coronaviruses that were genetically engineered to have the same mutations as those in the strain that is causing scientists so much concern.

Immune Response 52

Immune Response Genetic Engineering Vaccination Vaccine 52

Scienmag

MARCH 1, 2021

Credit: Earlham Institute Respiratory viruses such as SARS-CoV-2 (causing COVID-19) can often catalyse an overactive immune response that leads to a life-threatening cycle, known as a cytokine storm.

Immune Response 59

Immune Response Bioinformatics Allergies Genetics 59

Cloudbyz

MARCH 6, 2024

For example, monoclonal antibodies, a type of biologic, can selectively bind to specific targets such as proteins or cells involved in disease processes, thereby modulating immune responses or inhibiting disease progression.

Gene 71

Gene Immune Response Manufacturing Gene Therapy 71

Pharmaceutical Technology

MAY 2, 2023

The most widely utilised IO class is immune checkpoint inhibitors (ICIs), which work by blocking the inhibitory interactions between tumour cells and T-cells, facilitating an anti-tumour immune response. There are more than 20 marketed ICIs with approvals across a very wide spectrum of solid tumour indications.

Genetic Engineering 130

Genetic Engineering Antibody Clinical Trials Clinical Trials 130

The Pharma Data

DECEMBER 16, 2020

Currently in Phase 3 clinical testing in the United Kingdom for the prevention of COVID-19, NVX-CoV2373 is a recombinant protein vaccine adjuvanted with Novavax’ proprietary Matrix-M to enhance the immune response. About Novavax. Novavax, Inc.?(Nasdaq: Novavax Forward Looking Statements.

Protein 52

Protein Vaccination Vaccine Immune Response 52

Drug Discovery World

JANUARY 22, 2024

The MIS is developing novel vaccine concepts for broad and potent protective immune responses against influenza virus for patients, as well as to provide a mechanistic principle for designing vaccines for other hypervariable pathogens such as coronaviruses and HIV-1 2.

Engineer 59

Engineer Immune Response Drugs Vaccination 59

Scienmag

MARCH 19, 2021

Delivering vaccines directly to the lungs can boost immune responses to respiratory infections or lung cancer, study finds. CAMBRIDGE, MA — Many viruses infect their hosts through mucosal surfaces such as the lining of the respiratory tract.

Vaccination 48

Vaccination Vaccine Immune Response Development 48

The Pharma Data

DECEMBER 13, 2020

SYNB1891 is an investigational drug for the intra-tumoral treatment of solid tumors and lymphoma, composed of an engineered Synthetic Biotic designed to activate the STING pathway in the tumor microenvironment in order to upregulate the patient’s immune response. Synlogic’s President and Chief Executive Officer.

Immune Response 40

Immune Response Engineer Clinical Trials Clinical Trials 40

pharmaphorum

APRIL 8, 2022

It was shown to activate cell-killing immune responses via natural killer (NK) and CD8+ cells, as well as antigen-presenting cells. The deal is also a first partnership focusing on Werewolf’s PREDATOR protein engineering platform, which also includes IL-2 (WTX-124) and IL-12 (WTX-330) candidates preclinical development.

Drugs 105

Drugs Immune Response Licensing Licensing 105

The Pharma Data

APRIL 22, 2023

However, many of those therapies cause severe side effects in different parts of the body, including the immune system itself, and thus carry significant health risks. Now, a research team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard John A.

Immune Response 40

Immune Response Engineer In-Vivo Containment 40

pharmaphorum

JANUARY 10, 2023

Since then, the two partners have developed multiple AI-based applications including a platform for selecting neoantigens for use in individualised cancer vaccines and an early warning system for high risk SARS-CoV-2 variants based on how well they can evade the immune system and their transmissibility.

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Vaccination Vaccine Clinical Trials Clinical Trials 116

pharmaphorum

MARCH 3, 2021

Novavax’s vaccine is a sequence of protein engineered from the genetic sequence of the SARS-CoV-2 virus that mimics the “Spike” protein found on the pathogen’s surface. It cannot replicate or cause the disease but does produce a strong immune response that neutralises the virus in the event of an infection.

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Vaccination Vaccine Regulation Immune Response 130

pharmaphorum

NOVEMBER 23, 2021

The French drugmaker has been enticed by an artificial intelligence (AI) algorithm developed by Chinese tech giant Baidu, which controls most of China’s search engine traffic and is sometimes referred to as the country’s Google.

Licensing 105

Licensing Licensing Vaccination Vaccine 105

The Pharma Data

NOVEMBER 22, 2020

The Agreement extends an existing relationship between the companies and gives Pandion the option to use standard phage display or mammalian display as the engines for the discovery of next generation antibodies.

Antibody 52

Antibody Immune Response Engineer Protein 52

pharmaphorum

JANUARY 17, 2023

The company’s pipeline rests on a proprietary lymph node-targeting Amphiphile (AMP) technology, targeting the site in the body where immune responses are orchestrated. Darrell Irvine.

Immune Response 93

Immune Response Trials Engineer Sales 93

Drug Discovery World

SEPTEMBER 9, 2022

A new genetically engineered herpes virus has delivered a one-two punch against advanced cancers in initial findings from a Phase I trial. The genetically engineered RP2 virus, which is injected directly into the tumours, is designed to have a dual action against tumours. Of these, six remained progression-free at 14 months.

Research 52

Research Genetic Engineering Engineer Immune Response 52

XTalks

AUGUST 17, 2020

Cue Biopharma is a Cambridge, Massachusetts-based clinical-stage biotechnology company that is focused on developing injectable immune biologics using its proprietary Immuno-STAT (Selective Targeting and Alteration of T cells) platform. Cell-Based Immunotherapy vs. Immune Biologics. Immune system modulators (i.e.

Protein 98

Protein Engineer Immune Response In-Vivo 98

Drug Discovery World

FEBRUARY 19, 2024

The paper evaluated a transplant of Sana Biotechnology’s engineered allogeneic, HIP-modified pancreatic islet cells into a fully immunocompetent, diabetic NHP. C-peptide levels reached normal levels and there was no indication that the allogeneic HIP p-islet graft induced any immune recognition or any type of immune response at any time.

Insulin 52

Insulin Immune Response Engineer Antibody 52

XTalks

NOVEMBER 30, 2023

Preclinical data demonstrated that HB-500 was well-tolerated, eliciting robust, high-quality and enduring immune responses, including antigen-specific T cells and antibodies, in non-human primates. In November 2023, Hookipa Pharma Inc., Notably, it significantly reduced viral load and clinical illness compared to a placebo.

FDA Approval 111

FDA Approval Gene Therapy Clinical Trials Clinical Trials 111

Advarra

JANUARY 11, 2024

After injection of such a vaccine, the mRNA instructs cells to produce proteins designed to stimulate an immune response against these same protein targets when they show up in viruses or in tumor cells. Adoptive T Cell Therapies Adoptive T cell therapy is another form of cancer treatment leveraging the patient’s immune system.

Vaccination 52

Vaccination Vaccine Protein Antibody 52

pharmaphorum

OCTOBER 21, 2022

Hookipa’s proprietary arenavirus platform is based on engineering arenaviruses to carry and deliver virus-specific or tumour-specific genes directly in patients in order to evoke an immune response by T cells, also known as CD8+ T cells.

Licensing 52

Licensing Licensing Immune Response Engineer 52

Cloudbyz

MARCH 5, 2024

They are often used to mimic or enhance natural biological processes, such as immune responses. Immunogenicity : Small Molecules: Generally have a lower risk of inducing an immune response in the body. Biologics: Biologics can work in a variety of ways, including targeting specific cells, proteins, or pathways.

Development 75

Development Drugs Manufacturing Immune Response 75

pharmaphorum

MARCH 10, 2021

The study suggests that serum taken from patients injected with the mRNA shot, also known as BNT162b2, was able to neutralise a genetically engineered version of SARS-CoV-2 with the P.1 1 – that is worrying health officials around the world. . 1 mutations, as well as variants from the UK and South Africa.

Vaccination 66

Vaccination Vaccine Genetic Engineering Engineer 66