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Gene Switch: A Novel Platform for Switching Genes On and Off

Roots Analysis

For instance, studies have demonstrated that gene switches incorporated in gene therapies being developed for the treatment of anemia can regulate the production of hormone erythropoietin. Additionally, the genetically modified cell therapies might transform into uncontrollable mutant cells when the switch is inactivated.

Gene 40
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Accelerating NDA filing through faster carcinogenicity assessment

Drug Discovery World

They encourage an integrated analysis of risk considering many factors, including drug target biology and evidence for hormonal or immunological perturbation. Moving forward The latest revisions to ICH S1B represent a significant modernisation of carcinogenicity assessment of small molecule drugs. Toxicologic Pathology. 2011;39(4):716-744.