article thumbnail

Delivering on the promise of gene editing

Drug Discovery World

Inducing double strand breaks at unintended locations in the genome can lead to off-target genetic modifications that are difficult to predict and potentially deleterious. Complicating matters even more, researchers currently lack effective and reliable methods for detecting and measuring off-target genomic events.

article thumbnail

The importance of glycan analysis and characterisation for biopharma

Drug Discovery World

This progress includes the expansion of genomic sciences and the ability to design cell bioprocessing platforms for biotherapeutics production that can be used to address previously unmet medical needs. The mechanism of action depends upon their strong affinity to molecular targets associated with disease. . The glycan database .

Protein 52
article thumbnail

Optimising AAV capsid purification through improved analytics

Drug Discovery World

First, empty capsids may have the potential to induce an elevated immune response to high concentrations of viral particles. Methods such as ELISA/qPCR offer well-established, sensitive, and specific analyses that can measure capsid titre versus genome titre, quantifying empty and full capsids 3.