Conversations from ESMO Targeted Anticancer Therapies Congress 2024
Drug Discovery World
MARCH 26, 2024
We were excited to unveil data showing that two distinct chemical series exhibit METTL1 inhibition in vitro at low nanomolar concentrations with minimal interference with other RNA and protein methyltransferases. In vivo, METTL1 inhibitors induce tumour growth inhibition in both immune-deficient and immune-competent mouse strains.
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