Rethinking Clinical Trials

MARCH 1, 2023

We got both Merck and Lily to work together in the Phase II trial, then the data from that trial that showed survival benefit led to the Phase III study. There is a strong mechanistic rationale. They are both approved and used widely in lung cancer, and combining two existing agents is logistically and clinically simpler.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Packaging 130

pharmaphorum

APRIL 5, 2022

The one-year survival rate with the drug was 73%, compared to 58% in a group receiving standard-of-care – off-label immune checkpoint inhibitors used for other forms of melanoma like Merck & Co’s Keytruda (pembrolizumab) and Bristol-Myers Squibb’s Yervoy (ipilimumab) or chemotherapy with dacarbazine.

Sales 52

Sales Protein Drugs Trials 52

pharmaphorum

JANUARY 5, 2021

First-line immunotherapy for NSCLC is dominated by Merck & Co’s PD-1 inhibitor Keytruda (pembrolizumab), transforming the prospects of some patients and propelling the drug to multibillion-dollar sales. The post Roche nabs breakthrough tag for TIGIT cancer immunotherapy appeared first on.

Immune Response 52

Immune Response FDA Approval Drugs Sales 52

pharmaphorum

NOVEMBER 27, 2022

Fully integrated and automated ingredient to consumer batch tracking using barcoding, RFID tagging, or IoT temperature logging and timestamping significantly reduces the chance of these mix-ups, providing complete traceability records from ingredient manufacturer to patient, and ensures the safety of the product.

Production 105

Production Manufacturing Drugs Marketing 105

pharmaphorum

NOVEMBER 28, 2022

Substra is the software that powered the MELLODDY platform, a collaboration in which Amgen, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, GSK, Janssen, Merck, Novartis, and Servier all agreed to share drug discovery data — but not with each other directly, nor with Owkin.

Pharma Companies 72

Pharma Companies Life Science Research Development 72

Delveinsight

DECEMBER 3, 2020

It has been speculated that modifications to the epigenome drive cell ageing, especially a process known as DNA methylation, by which methyl groups are tagged onto DNA. Merck chooses TriNKET cancer immunotherapy program. Merck has snapped up Dragonfly’s TriNKET cancer immunotherapy program.

Gene Therapy 52

Gene Therapy Gene Antibody Research 52

XTalks

AUGUST 17, 2020

Cue Biopharma has an autoimmune disease collaboration with Merck, from which early data from a type 1 diabetes program was released earlier this year by the pharma company. The beauty with Neo-STAT is that you can make the entire [HLA-based] scaffold along with the IL-2 elements for cancer immunotherapy without a peptide.

Protein 98

Protein Engineer Immune Response In-Vivo 98

Drug Discovery World

NOVEMBER 13, 2023

Immunocytokines Following chairperson’s remarks from Stefan Zielonka, PhD, Global Head of Antibody Discovery and Protein Engineering, Merck Healthcare KGaA; Professor of Biomolecular Immunotherapy, Technical University of Darmstadt, there will be a keynote presentation from Roberto De Luca, PhD, Head, Therapeutic Antibodies, Philochem.

Protein 59

Protein Antibody Engineer Scientist 59

The Pharma Data

MAY 5, 2021

Roger Perlmutter, former Merck R&D head, becomes CEO of super-microscopy startup ( STAT ) ( Endpoints ). AbbVie’s Humira regains top pharma TV spender spot, while sibling brands Rinvoq and Skyrizi tag along ( Fierce ). Merck KGaA raises forecast for full year 2021 ( Pharmaletter ).

Vaccination 52

Vaccination Vaccine Gene Therapy Contract Packaging 52