Trials, Vaccination and Vaccine - Clinical Research Informer

BioNTech targets infectious diseases for vaccine development

Pharmaceutical Technology

MARCH 28, 2023

Following on from its Covid-19 vaccine programmes, BioNTech has set its sights on a range of infectious diseases for vaccine development. The company saw major successes with its Covid-19 vaccine, developed in collaboration with Pfizer. In response to the lower vaccine sales forecasts, BioNTech shares opened at 3.9%

Vaccination

Vaccination Vaccine Development Clinical Trials

BioNTech’s RNA vaccine sparks potential in pancreatic cancer

Pharmaceutical Technology

MAY 11, 2023

Results published in Nature for a personalised pancreatic cancer vaccine that uses neoantigens from patients’ tumours have lent further support to early positive signals. The vaccine, developed by BioNTech, led to half of the patients with pancreatic cancer in the Phase I trial remaining cancer-free 18 months later.

RNA

RNA Vaccination Vaccine Trials

Experimental Alzheimer’s Vaccine Shown to Delay Symptoms in Mice

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 3, 2023

An experimental vaccine that aims to slow down or prevent the progression of Alzheimer’s disease has been trialed in mice with promising early results. Mice engineered with genes that put them at greater risk of an Alzheimer’s-like disease had fewer amyloid plaques following the vaccine.

Vaccination

Vaccination Vaccine Engineer Gene

Brazil’s ANVISA approves Takeda’s dengue vaccine candidate Qdenga

Pharmaceutical Technology

MARCH 14, 2023

The National Health Surveillance Agency (ANVISA) in Brazil has granted approval for Takeda ’s dengue virus vaccine candidate, Qdenga (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003). The vaccine has received approval for preventing dengue disease in people aged four years to 60 years.

Vaccination

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“Game-changing” personalised cancer vaccine enters UK clinical trials

Drug Discovery World

APRIL 26, 2024

A clinical trial of a personalised mRNA cancer vaccine for melanoma patients has been launched in the UK. The vaccines are personalised to each patient after a tumour sample is removed during surgery and then analysed using DNA sequencing. in the combination arm and 62.2%

Clinical Trials

Clinical Trials Clinical Trials Vaccination Vaccine

Pfizer begins plan to challenge Shingrix with an mRNA vaccine

Bio Pharma Dive

FEBRUARY 10, 2023

The pharma and partner BioNTech have kicked off the first human trial of a messenger RNA shot for shingles, believing there’s room to clear the high bar set by GSK’s rival vaccine.

Vaccination

Vaccination Vaccine RNA Trials

Malaria Could Be Eliminated by 2040: New Vaccine Offers Hope

AuroBlog - Aurous Healthcare Clinical Trials blog

OCTOBER 8, 2023

The World Health Organization has approved a new vaccine that scientists argue will be a game-changer in the fight against malaria, which kills half a million people in Africa every year.

Vaccination

Vaccination Vaccine Scientist Trials

HIV vaccines suffer setbacks but new approaches could turn the tide

Pharmaceutical Technology

FEBRUARY 3, 2023

Only a few weeks into the new year, the prospect of getting a successful advanced HIV vaccine shrank after the discontinuation of yet another late-stage trial. On January 18, Janssen, a Johnson & Johnson (J&J) subsidiary, stated that its vaccine was not effective in preventing HIV infections.

Vaccination

Vaccination Vaccine Antibody Trials

Radical Vaccine Strategy Could Help Quash Parasite Afflicting Millions

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 11, 2024

Using viruses that infect bacteria to detect proteins sprouted by a notorious parasite, scientists have honed in on possible vaccine targets for schistosomiasis, a neglected tropical disease that currently affects an estimated 600 million people worldwide, causing 280,000 deaths per year.

Vaccination

Vaccination Vaccine Bacteria Protein

UK MHRA approves Takeda’s dengue vaccine Qdenga

Pharmaceutical Technology

FEBRUARY 7, 2023

The UK Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorisation for Takeda ’s dengue virus vaccine candidate, Qdenga (Dengue Tetravalent Vaccine [Live, Attenuated]). The vaccine candidate has been approved for active immunisation against the infection in people from four years of age.

Vaccination

Vaccination Vaccine Genetics Trials

Ghana becomes first country to approve Oxford’s malaria vaccine

Pharmaceutical Technology

APRIL 14, 2023

Ghana’s Food and Drug Authority (FDA) has approved R21/Matrix-M malaria vaccine in children aged 5 to 36 months, marking the first regulatory clearance for the University of Oxford-developed vaccine in any country in the world. Children between the ages of five and 36 months are at highest risk of death from malaria.

Vaccination

Vaccination Vaccine Manufacturing Containment

MinervaX raises $57m for Phase III trial of maternal strep vaccine

Pharmaceutical Technology

OCTOBER 11, 2023

MinervaX is currently conducting Phase II trials of the prophylactic maternal vaccine against group B streptococcus bacterial infections.

Vaccination

Vaccination Vaccine Trials

China grants EUA to Covid-19 vaccine against XBB descendent lineages

Pharmaceutical Technology

JUNE 9, 2023

5+delta) protein vaccine (Sf9 cell). This marks the world’s first Covid-19 vaccine approved for emergency use against XBB descendent lineages of SARS-CoV-2. The vaccine has been developed by WestVac Biopharma along with the West China Medical Center and Sichuan University. recombinant Covid-19 trivalent (XBB.1.5+BA.5+delta)

Vaccination

Vaccination Vaccine HR Protein

Nouscom extends Series C round to $82m for cancer vaccine trials

Pharmaceutical Technology

MARCH 21, 2024

Nouscom is part of a cancer vaccine landscape that has recently jump-started following years of dormancy.

Vaccination

Vaccination Vaccine Trials

Successful clinical trial for re-engineered Covid vaccine

Drug Discovery World

NOVEMBER 24, 2023

The University of Queensland’s re-engineered clamp platform has produced a vaccine that is equally safe and virus-neutralising as an approved Covid vaccine considered among the best in its class. The Clamp2 trial group showed a 2.5-fold fold boost in neutralising ‘titres’ and it was 2.1 in the Novavax group.

Clinical Trials

Clinical Trials Clinical Trials Engineer Vaccination

Health Canada approves Novavax’s Covid-19 vaccine for adolescents

Pharmaceutical Technology

DECEMBER 7, 2022

Health Canada has granted approval for a supplement to a New Drug Submission (sNDS) of Novavax ’s Covid-19 vaccine (Recombinant protein, Adjuvanted), Nuvaxovid (NVX-CoV2373), for use in adolescents aged 12 to 17 years. The trial is designed to analyse the safety and effectiveness of the vaccine.

Vaccination

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GSK sets high bar with trial results for RSV vaccine

Bio Pharma Dive

OCTOBER 13, 2022

With data expected for several other vaccines for the respiratory disease, GSK reported positive clinical trial results showing efficacy above 80%.

Vaccination

Vaccination Vaccine Trials Clinical Trials

CMV Vaccine Trials: Moderna’s CMV mRNA Vaccine Enters Phase III

XTalks

FEBRUARY 19, 2024

Moderna has been testing an experimental mRNA vaccine aimed at combating the human cytomegalovirus (CMV), which poses significant health risks to newborns and immunocompromised patients. The team used the data and patient samples from a gB/MF59 Phase II trial in adolescent girls as a benchmark to assess the new mRNA-based vaccine.

Vaccination

Vaccination Vaccine Trials Clinical Trials

India grants approval for Bharat Biotech’s intranasal Covid-19 vaccine

Pharmaceutical Technology

SEPTEMBER 7, 2022

Indian company Bharat Biotech International has secured approval from Central Drugs Standard Control Organisation (CDSCO) under Restricted Use in Emergency Situation for its intranasal Covid-19 vaccine, iNCOVACC (BBV154), for usage in people aged 18 years and older. It is formulated to permit intranasal delivery via nasal drops.

Vaccination

Vaccination Vaccine Clinical Trials Clinical Trials

Extreme Case of Man Who Had 217 COVID Vaccines Surprises Scientists

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 12, 2024

That’s how many vaccines a man in Germany claims to have received for COVID-19 in just 29 months – and his body isn’t reacting the way some scientists thought it would. Two hundred and seventeen. The 62-year-old male from the city of Magdeburg made headlines a few years ago for his private and risky decision […]

Scientist

Scientist Vaccination Vaccine Clinical Trials

Pfizer and BioNTech post early win for combination Covid-19/flu vaccine

Pharmaceutical Technology

OCTOBER 26, 2023

A pivotal Phase III trial will be initiated in the coming months to further evaluate the lead formulations of the combination vaccine.

Vaccination

Vaccination Vaccine Trials

Moderna, in bid for transparency, discloses detailed plan of coronavirus vaccine trial

Bio Pharma Dive

SEPTEMBER 17, 2020

The biotech, among the furthest along in coronavirus vaccine development, is the first developer to share the so-called study protocol of its large Phase 3 trial.

Vaccination

Vaccination Vaccine Trials Development

Gates, Wellcome-backed TB vaccine starts phase 3 trial

pharmaphorum

MARCH 20, 2024

A highly anticipated phase 3 trial of a new tuberculosis vaccine developed by GSK has started in Africa, funded by the Gates MRI and Wellcome.

Vaccination

Vaccination Vaccine Trials Development

GSK speeds up the race to bring first RSV vaccine for older adults to market

Pharmaceutical Technology

OCTOBER 31, 2022

After decades of setbacks, the respiratory syncytial virus (RSV) vaccine field has bounced back with positive Phase III trial results in older adults. There are currently five players in the race, with vaccines in Phase III of development from GlaxoSmithKline (GSK) , Pfizer , Johnson & Johnson , Moderna and Bavarian Nordic.

Vaccination

Vaccination Vaccine Marketing Trials

Pfizer, after delay, completes enrollment in Lyme vaccine trial

Bio Pharma Dive

DECEMBER 5, 2023

The announcement ends a lengthy setback that began when the company and partner Valneva accused a clinical trial site operator of study misconduct.

Trials

Trials Clinical Trials Clinical Trials Vaccination

Moderna follows Pfizer in beginning trial of omicron vaccine

Bio Pharma Dive

JANUARY 26, 2022

New data, meanwhile, help affirm the benefit of a third dose of Moderna's current vaccine. The study will test a version of the biotech's COVID-19 shot that's tailored to the infectious variant.

Vaccination

Vaccination Vaccine Trials

HIV vaccine being developed by Johnson & Johnson fails clinical trial

STAT News

JANUARY 18, 2023

Yet another experimental HIV vaccine has failed. The National Institute of Allergy and Infectious Diseases reported Wednesday that a Phase 3 clinical trial of a vaccine was stopped because the vaccine was ineffective at preventing HIV infection. Read the rest…

Clinical Trials

Clinical Trials Clinical Trials Vaccination Vaccine

Merck to Start Trials of New HPV Vaccine and Single-Dose Gardasil Shot

BioSpace

MARCH 13, 2024

Merck is looking to expand its offerings in the human papillomavirus space with a new vaccine and to study a single-shot variant of Gardasil 9, both of which will start trials toward the end of 2024.

Vaccination

Vaccination Vaccine Trials

CanSino, Canada abandon plans for a coronavirus vaccine trial

Bio Pharma Dive

AUGUST 27, 2020

Canada was set to help CanSino produce its experimental shot as part of a deal to run what would've been the country's first coronavirus vaccine study.

Vaccination

Vaccination Vaccine Trials

Novavax’s Covid-19 vaccine gets Taiwan FDA EUA for use in adults

Pharmaceutical Technology

JUNE 24, 2022

Novavax has obtained emergency use authorization (EUA) for its Covid-19 vaccine, Nuvaxovid (NVX-CoV2373), from the Taiwan Food and Drug Administration for use in people of the age 18 years and above. The protein-based vaccine is engineered from the genetic sequence of the SARS-CoV-2 virus’ initial strain.

Vaccination

Vaccination Vaccine Clinical Trials Clinical Trials

ICON partners with US Government for clinical trials of Covid-19 vaccines

Pharmaceutical Technology

SEPTEMBER 14, 2023

ICON will conduct Phase IIb clinical trials for the US BARDA-selected Covid-19 vaccine candidates as part of ‘Project NextGen’.

Clinical Trials

Clinical Trials Clinical Trials Vaccination Vaccine

Chinese drugmaker Clover says vaccine prevents COVID-19 in large trial

Bio Pharma Dive

SEPTEMBER 22, 2021

Positive results from Clover's Phase 3 study could mean another coronavirus vaccine option for the many countries still grappling with short supplies.

Vaccination

Vaccination Vaccine Trials

Novavax says vaccine 90% effective against COVID-19 in large trial

Bio Pharma Dive

JUNE 14, 2021

Highly anticipated results from a Phase 3 study testing the biotech company's shot showed it to be strongly protective and safe, a potential boon for the world's vaccination efforts.

Vaccination

Vaccination Vaccine Trials

EC approves Novavax’s Covid-19 vaccine CMA expansion for adolescents

Pharmaceutical Technology

JULY 6, 2022

The European Commission (EC) has granted approval for the expanded conditional marketing authorization (CMA) of Novavax’s Covid-19 vaccine, Nuvaxovid (NVX-CoV2373), in the European Union (EU) for adolescents of the age 12 to 17 years. A protein-based vaccine, NVX-CoV2373 is made from the genetic sequence of the SARS-CoV-2 virus’ first strain.

Vaccination

Vaccination Vaccine Protein Clinical Trials

India’s CDSCO approves Bharat Biotech’s intra-nasal vaccine for Covid-19

Pharmaceutical Technology

DECEMBER 2, 2022

India’s Central Drugs Standard Control Organisation (CDSCO) has granted approval for Bharat Biotech’s BBV154 vaccine for treating Covid-19. BBV154 is claimed to be the first intra-nasal vaccine for Covid-19 in the world.

Vaccination

Vaccination Vaccine Clinical Trials Clinical Trials

YS Biopharma’s Rabies Vaccine Outperforms Commercial Competitor in Phase III Trial

BioSpace

APRIL 10, 2024

Late-stage study results released Tuesday show YS Biopharma’s rabies vaccine candidate can induce twice the seroconversion rate at seven days versus a standard, globally marketed comparator.

Vaccination

Vaccination Vaccine Trials Marketing

Moderna’s HIV vaccine prepped for trials in Africa

pharmaphorum

MAY 19, 2022

Moderna has joined forces with non-profit organisation IAVI on a third phase 1 trial of its candidate HIV vaccine in Africa, where the burden of the virus is still being keenly felt. One candidate – mRNA-1644 – has already shown its potential in an earlier phase 1 trial (IAVI G001) run in the US.

Vaccination

Vaccination Vaccine Trials Immune Response

Breakthrough UTI vaccine could prevent infections for nine years

BioPharma Reporter

APRIL 8, 2024

Recurring urinary tract infections (UTIs) can be prevented for up to nine years with a simple oral spray vaccine, a âbreakthroughâ British trial has shown.

Vaccination

Vaccination Vaccine Trials Development

Diakonos’ brain tumour vaccine wins FDA’s orphan drug designation

Pharmaceutical Technology

JANUARY 3, 2024

The immuno-oncology company has also completed enrolment in a Phase I trial investigating its dendritic cell vaccine DOC1021.

Vaccination

Vaccination Vaccine Drugs Trials

Ebola experimental vaccine trial may begin soon in Uganda

STAT News

SEPTEMBER 29, 2022

A clinical trial of one or perhaps two experimental vaccines designed to protect against the Ebola Sudan virus could soon begin in Uganda, as long as the country agrees to allow the research to take place, an official of the World Health Organization said Wednesday. Read the rest…

Vaccination

Vaccination Vaccine Trials Clinical Trials

Africa-led HIV vaccine trial ends in failure

pharmaphorum

DECEMBER 8, 2023

Africa-led HIV vaccine trial ends in failure Phil.Taylor Fri, 08/12/2023 - 10:24 Bookmark this

Vaccination

Vaccination Vaccine Trials

Mixed results for Moderna mRNA flu vaccine trial

Medical Xpress

FEBRUARY 16, 2023

US biotech company Moderna said Thursday it had mixed results from a large-scale trial of its mRNA flu shot, based on the same technology used in its successful Covid-19 vaccine.

Vaccination

Vaccination Vaccine Trials

Velocity Wins the 2024 Vaccine Industry Excellence Award for Best Clinical Trial Company

Velocity Clinical Research

APRIL 3, 2024

Velocity has won the 2024 Vaccine Industry Excellence (ViE) award for Best Clinical Trial Company at The World Vaccine Congress in Washington, DC. The recognition is based on performance metrics, diversity of vaccine trial capabilities, and key initiatives to support vaccine research. and Europe.

Clinical Trials

Clinical Trials Clinical Trials Vaccination Vaccine

Clinical trial will test novel inhaled TB vaccine

Drug Discovery World

JANUARY 16, 2024

A new study will compare whether giving tuberculosis vaccine by inhalation is better at protecting against tuberculosis (TB) than injection into the skin. The Jenner Institute at the University of Oxford is conducting the study using Bacille Calmette-Guérin (BCG), the current licensed vaccine against TB.

Clinical Trials

Clinical Trials Clinical Trials Vaccination Vaccine

BioNTech targets infectious diseases for vaccine development

BioNTech’s RNA vaccine sparks potential in pancreatic cancer

Trending Sources

Experimental Alzheimer’s Vaccine Shown to Delay Symptoms in Mice

Brazil’s ANVISA approves Takeda’s dengue vaccine candidate Qdenga

“Game-changing” personalised cancer vaccine enters UK clinical trials

Pfizer begins plan to challenge Shingrix with an mRNA vaccine

Malaria Could Be Eliminated by 2040: New Vaccine Offers Hope

HIV vaccines suffer setbacks but new approaches could turn the tide

Radical Vaccine Strategy Could Help Quash Parasite Afflicting Millions

UK MHRA approves Takeda’s dengue vaccine Qdenga

Ghana becomes first country to approve Oxford’s malaria vaccine

MinervaX raises $57m for Phase III trial of maternal strep vaccine

China grants EUA to Covid-19 vaccine against XBB descendent lineages

Nouscom extends Series C round to $82m for cancer vaccine trials

Successful clinical trial for re-engineered Covid vaccine

Health Canada approves Novavax’s Covid-19 vaccine for adolescents

GSK sets high bar with trial results for RSV vaccine

CMV Vaccine Trials: Moderna’s CMV mRNA Vaccine Enters Phase III

India grants approval for Bharat Biotech’s intranasal Covid-19 vaccine

Extreme Case of Man Who Had 217 COVID Vaccines Surprises Scientists

Pfizer and BioNTech post early win for combination Covid-19/flu vaccine

Moderna, in bid for transparency, discloses detailed plan of coronavirus vaccine trial

Gates, Wellcome-backed TB vaccine starts phase 3 trial

GSK speeds up the race to bring first RSV vaccine for older adults to market

Pfizer, after delay, completes enrollment in Lyme vaccine trial

Moderna follows Pfizer in beginning trial of omicron vaccine

HIV vaccine being developed by Johnson & Johnson fails clinical trial

Merck to Start Trials of New HPV Vaccine and Single-Dose Gardasil Shot

CanSino, Canada abandon plans for a coronavirus vaccine trial

Novavax’s Covid-19 vaccine gets Taiwan FDA EUA for use in adults

ICON partners with US Government for clinical trials of Covid-19 vaccines

Chinese drugmaker Clover says vaccine prevents COVID-19 in large trial

Novavax says vaccine 90% effective against COVID-19 in large trial

EC approves Novavax’s Covid-19 vaccine CMA expansion for adolescents

India’s CDSCO approves Bharat Biotech’s intra-nasal vaccine for Covid-19

YS Biopharma’s Rabies Vaccine Outperforms Commercial Competitor in Phase III Trial

Moderna’s HIV vaccine prepped for trials in Africa

Breakthrough UTI vaccine could prevent infections for nine years

Diakonos’ brain tumour vaccine wins FDA’s orphan drug designation

Ebola experimental vaccine trial may begin soon in Uganda

Africa-led HIV vaccine trial ends in failure

Mixed results for Moderna mRNA flu vaccine trial

Velocity Wins the 2024 Vaccine Industry Excellence Award for Best Clinical Trial Company

Clinical trial will test novel inhaled TB vaccine

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