Remove Bacteria Remove Engineer Remove Genome Remove Protein
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For bacteria, a small genome means some serious decluttering — even in the ribosome

Scienmag

Researchers from Skoltech, Lomonosov Moscow State University, and the Kharkevich Institute for Information Transmission Problems have studied the genomes of some 200 strains of bacteria to determine which proteins in the ribosome, part of the key cell machinery, can be safely lost and why.

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How digital innovation is helping therapeutics to get to market faster

Drug Discovery World

Sanofi has stated that it intends to become the first pharma company “powered by AI at scale”, and as part of this ambition, agreed a collaboration with BioMap to co-develop advanced AI models and protein Large Language Models that that it hopes will enable biologics design and multiparametric optimisation 2. Obulytix is not alone.

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2020 Year in Review: COVID-19, CRISPR and Immunotherapies Define the Year for the Life Sciences

XTalks

From isolating SARS-CoV-2 in early January to sequencing its genome shortly thereafter and having a prototype vaccine against it within days, scientific process and progress have held steadfast throughout the pandemic. Most antibody drugs and vaccines have been developed to target parts of the spike protein. Innovations.

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Winship Cancer Institute of Emory University Joins Caris’ Precision Oncology Alliance

The Pharma Data

By leveraging the comprehensive genomic, transcriptomic and proteomic profiling available through the Caris Molecular Intelligence® platform, physicians from Winship will be able to further prioritize therapeutic options and determine which clinical trial opportunities may benefit their patients.

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Improving quality control for CAR T cell therapies

Drug Discovery World

Finally, in 2017, after years of improving T cell engineering techniques, the first chimeric antigen receptor (CAR) T cell therapy received FDA approval. The immune system typically identifies foreign entities such as bacteria and viruses and activates lymphocytes such as T cells to destroy them with overwhelming force.

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Can artificial intelligence help craft new medicines?

Drug Discovery World

The magic bullet was the drug, while the specific mark it would reach in the syphilis causing bacteria to eliminate the disease was the drug target. The drug target for Penicillin is a protein that helps bacteria to synthesise its cell wall. Salvarsan was soon overtaken by the Penicillin antibiotics.

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Stanford researchers construct the most complete synthetic microbiome

Drug Discovery World

While scientists routinely silence a gene or remove a protein from a specific cell or even an entire mouse, there is no such set of tools to remove or modify one species among the hundreds in a given faecal sample. “So They introduced hCom1 to mice that are carefully designed to have no bacteria present. Building the ark.