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For bacteria, a small genome means some serious decluttering — even in the ribosome

Scienmag

Researchers from Skoltech, Lomonosov Moscow State University, and the Kharkevich Institute for Information Transmission Problems have studied the genomes of some 200 strains of bacteria to determine which proteins in the ribosome, part of the key cell machinery, can be safely lost and why.

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Boehringer backs AI-powered anti-infective startup ArrePath

pharmaphorum

The approach combines phenotypic screening, proteomics, and genomics-based technologies with machine learning-powered analysis of data, avoiding the use of standard growth inhibition assays which can be slow and may miss potentially promising mechanisms. million deaths a year, according to the 2019 Gram Report. Dr Zemer Gitai.

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‘Living medicine’ created to treat drug-resistant infections

Scienmag

Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. Credit: María Lluch/CRG Researchers at […].

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How digital innovation is helping therapeutics to get to market faster

Drug Discovery World

Researchers from the University of Oslo, University of Chicago Pritzker School of Medicine, and Insilico Medicine used an AI target discovery engine to analyse transcriptomic data to identify dual targets for cancer and ageing 5. Digital tech is also helping researchers to find target candidates for some of the most challenging disease areas.

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One world, one health: The interconnected web of antimicrobial resistance

pharmaphorum

That’s according to a newly published report from the US National Academies of Sciences, Engineering, and Medicine, which calls for a One Health approach that recognises the scale of the challenge, and the interconnectivity of its potential solutions. Surveillance.

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Winship Cancer Institute of Emory University Joins Caris’ Precision Oncology Alliance

The Pharma Data

By leveraging the comprehensive genomic, transcriptomic and proteomic profiling available through the Caris Molecular Intelligence® platform, physicians from Winship will be able to further prioritize therapeutic options and determine which clinical trial opportunities may benefit their patients.

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Researchers develop technique to functionally identify and sequence soil bacteria one cell at a time

Scienmag

Credit: LIU Yang Researchers from the Single-Cell Center at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences have developed a technique to sort and sequence the genome of bacteria in soil one bacterial cell at a time, while also identifying what its function is in the soil environment. […]. (..)