Roots Analysis

NOVEMBER 30, 2021

Bioassay – A Prerequisite for the Cell and Gene Therapy Development. Over the past few years, investigational new drug (IND) filings for cell and gene therapy product have significantly increased. Bioassays are biochemical procedures that are used to evaluate the potency, purity and efficacy of a drug substance.

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Drug Discovery World

NOVEMBER 9, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Croasdale-Wood will then participate in a keynote chat, interviewed by Miho.

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Engineer Antibody Protein In-Vivo 52

Drug Discovery World

NOVEMBER 30, 2023

Next-generation immunotherapies In the session focused on cell-based immunotherapies, Steven Quistad, Senior Applications Scientist, DNA Script, presented on how to rapidly assemble genes in a laboratory using automated enzymatic oligo synthesis. To demonstrate the utility of the company’s SYNTAX system in gene assembly, the 1.7

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Antibody Protein Engineer In-Vivo 59

Drug Discovery World

MAY 4, 2023

Here, new bioassay technologies helped testing, but more definite answers were required. Expression patterns, proteomic profiles, bioassay results, and structures could now be captured en masse in normal and disease conditions. Thus, there was a dire need for new and effective drug targets.

Medicine 52

Medicine Protein Drugs Bioassay 52

Drug Discovery World

MAY 10, 2023

Carcinogenicity testing For decades, the two-year rodent bioassay has been the regulatory standard used to determine the carcinogenic potential of new drugs. This process historically involved lifetime carcinogenicity bioassays in two species. Figure 1: Comparing Carcinogenicity Testing Timelines in Transgenic vs. Standard Mice.

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The Pharma Data

MAY 13, 2021

Aspartame bioassay findings portend human cancer hazards. Journal of Food Engineering. Opiate-like effects of sugar on gene expression in reward areas of the rat brain. Huang D, Dhawan T, Young S, et al. Fructose impairs glucose-induced hepatic triglyceride synthesis. Lipids Health Dis. 2011;10:20 DOI: 10.1186/1476-511X-10-20 .

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Insulin Production Hormones Medicine 52