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Using analytics and bioassays to de-risk your mRNA LNP drug development programme

Pharmaceutical Technology

RNA has the potential to underpin breakthrough treatments for a wide variety of diseases, including many cancers, and transform medicine as we know it. Another area where we tend to see problems is in encapsulation efficiency,” says Andrew Kondratowicz, Bioassay Team Lead, Precision NanoSystems. Where is your payload?

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RNA-based immunotherapy eradicates melanoma tumours

Drug Discovery World

Investigators at the Icahn School of Medicine at Mount Sinai have designed an RNA-based strategy to activate dendritic cells that eradicated tumours and prevented their recurrence in mouse models of melanoma. The researchers named their approach CATCH. Next, the researchers plan to start early-phase clinical trials for patients.

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How ML and automation are changing the future of protein therapeutics

Drug Discovery World

Kristen Hopson , Vice President of Preclinical Discovery and Development at Generate Biomedicines, and Yup Liu , Associate Director, HTS at Generate Biomedicines, reflect on the impact of AI, ML cloud computing, and advances in laboratory automation and high-throughput screening (HTS) on life science research.

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Can artificial intelligence help craft new medicines?

Drug Discovery World

Here, new bioassay technologies helped testing, but more definite answers were required. Expression patterns, proteomic profiles, bioassay results, and structures could now be captured en masse in normal and disease conditions. The post Can artificial intelligence help craft new medicines?

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What to expect from PEGS Europe 2023: Day 2

Drug Discovery World

Novel platforms This session will begin with chariperson’s remarks from Lars Linden, PhD, Vice President, Head, Biologics Research, Bayer HealthCare, which will be followed by a keynote presentation by Agnieszka Kielczewska, PhD, Director, Research, Antibody Discovery and Screening, Biologics Discovery, Amgen.

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Accelerating NDA filing through faster carcinogenicity assessment

Drug Discovery World

While the discovery phase – which includes target discovery, target validation, lead compound identification, and lead compound optimisation – averages several years and $200 million, the majority of the research, time, and financial spend takes place downstream in drug development. In practice, this was typically conducted in rats and mice.

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Let's Quit Sugar With Audiobook – Let's Quit Sugar

The Pharma Data

Experimental Diabetes Research. Effects of almond consumption on the reduction of LDL-cholesterol: a discussion of potential mechanisms and future research directions. The Yale Journal of Biology and Medicine. Journal of strength and conditioning research / National Strength & Conditioning Association. 2014.09.007.

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