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EverGrain’s Line of Barley-Based Products Scores Upcycled Certification

XTalks

After five years of research and development, the brand found a way to transform saved grain from brewing into nutrient-rich, barley-based proteins and fibers that have a variety of applications in the food and beverage industry. billion by 2027 at a compound annual growth rate (CAGR) of two percent, according to Research and Markets.

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CycPeptMPDB: A database aimed at promoting drug design using cyclic peptides

The Pharma Data

CycPeptMPDB, a novel database – created by Tokyo Tech researchers – focused on the membrane permeability of cyclic peptides, could accelerate the development of drugs based on these promising compounds. That is why, in recent years, cyclic peptides have become a very active research area.

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The impact of AI and ML on the future of drug discovery  

Drug Discovery World

JV: A key bottleneck in the research and development of a drug is the lengthy experimentation that is required to gain the confidence to run clinical trials. Here, she discusses with DDW’s Megan Thomas the impact of AI and ML on the drug discovery process. MT: How does AI and ML accelerate the drug discovery process?

Drugs 109
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Cell-penetrating peptides as a delivery system for oligonucleotides

Drug Discovery World

Oligonucleotides act on the RNA level through different molecular pathways, but there is a major drawback when using them as drugs: their poor bioavailability and cellular uptake. These peptides typically contain up to 30 amino acids and can be cationic, amphipathic or both. These considerations limit their application as therapeutics.

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Kronos Bio Announces Publication of Preclinical Study Results for Investigational CDK9 Inhibitor KB-0742 in Cell Chemical Biology

The Pharma Data

Research s howed KB-0742 i nhibited a ndrogen r eceptor -d ependent a ctivity and r educed t umor g rowth in c astration -r esistant p rostate c ancer. We designed KB-0742 to be an orally bioavailable CDK9 inhibitor with a differentiated selectivity profile,” said Norbert Bischofberger, Ph.D., SAN MATEO, Calif., and CAMBRIDGE, Mass.,

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Sosei Heptares’ COVID-19 Program Identifies Potent Broad Spectrum Anti-Viral Small Molecules for Further Development

The Pharma Data

These compounds have demonstrated high potency in inhibiting the activity of the M pro protease as well as promising oral bioavailability and blood plasma levels in animal studies. The Company has created a covid19@soseiheptares.com contact address for companies and researchers who would like to discuss possible collaborations.

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Addressing the challenge of salt forms in drug discovery

Drug Discovery World

Some 5% of commercially available research compounds aresold as salt forms. These can have better properties than their parents, including preferable stability, solubility, bioavailability, and manufacturability. The research chemical supply market. The importance of salt forms in the commercially available chemicals market.

Drugs 52