pharmaphorum
JULY 28, 2022
Alnylam Pharma has made a name for itself, developing gene-silencing therapies for rare disorders, but its latest discovery could take it into a much larger category – metabolic and cardiovascular disease. Transgenic mice in which the gene has been deleted have improved control of blood glucose and insulin sensitivity.
The Pharma Data
JULY 12, 2021
The AI approach helps model a disease using a map of successive changes in gene expression at the onset and during the progression of the disease. The underlying algorithms ensure that the identified gene expression patterns are ‘invariant’ regardless of different disease cohorts. HUMANOID Center of Research Excellence?
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
The Pharma Data
APRIL 11, 2023
Based on these data, a first-in-human trial with BAY 2965501 in patients with advanced solid tumors was initiated and is currently enrolling patients. For the first time, Bayer will present the design of the clinical trial and the preclinical activity profile of the inhibitor in human epidermal growth factor receptor 2 (HER2) mutant NSCLC.
XTalks
APRIL 15, 2021
Late-stage clinical trial failures are largely to blame for the lack of effective treatment options for patients with HFpEF, and poor five-year survival rates make this an area of great unmet need. A lack of efficacy is the greatest reason for clinical trial failures, especially in Phase II and Phase III,” says Dr. Tyl.
The Pharma Data
JULY 8, 2021
Managed by the Broad Institute of MIT and Harvard, the browser gives access to results from analyses of whole exome sequencing data from 300,000 UK Biobank research participants. (Nasdaq: BIIB) and Pfizer (NYSE: PFE). These genetic data have been paired with detailed health information to create this browsable resource.
Drug Discovery World
OCTOBER 30, 2023
We previously conducted a hypothesis-free study using genotype data from the UK Biobank, which resulted in the first mechanism-based stratification of endometriosis patients. SG: Chronic diseases, like endometriosis, are polygenic, caused by a complex interplay of multiple genes and other factors.
Drug Discovery World
JANUARY 24, 2024
Fibrocor is on track to complete all IND-enabling work to support IND filing and initiation of clinical trials in 2024. The gene expression data were generated by RNAseq on biopsies stored at -78°C. He has been responsible for all aspects of drug discovery, preclinical research, CM&C, Phase I and Phase II clinical trials.
Expert insights. Personalized for you.
52 
Let's personalize your content