Rethinking Clinical Trials

JANUARY 3, 2024

In this Friday's PCT Grand Rounds, Rui Wang of Harvard Medical School will offer the final session in our special series, Advances in the Design and Analysis of Pragmatic Clinical Trials, with "Methods for Handling Missing Data in Cluster Randomized Trials." The session will be held on Friday, January 5, at 1:00 pm eastern.

Trials 286

Trials Clinical Trials Clinical Trials Medicine 286

Rethinking Clinical Trials

AUGUST 9, 2023

Data Sharing and Pragmatic Clinical Trials: Law & Ethics Amidst a Changing Policy Landscape Description Kayte Spector-Bagdady and Stephanie Morain discuss the impact of a changing policy landscape on data sharing and pragmatic clinical trials.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Medicine 130

pharmaphorum

JANUARY 17, 2023

Late last year, pharmaphorum spoke with AstraZeneca’s Ben Challis, VP and head of translational science and experimental medicine, cardiovascular, renal, and metabolism (CVRM), together with Magnus Jörnten-Karlsson, executive director of Unify. Unify, launched in December 2020, is AstraZeneca’s patient app and clinical trial support tool.

Clinical Trials 98

Clinical Trials Clinical Trials Medicine Trials 98

Rethinking Clinical Trials

JUNE 28, 2023

In this Friday’s PCT Grand Rounds, Adrian Hernandez, Pamela Tenaerts, and Craig Lipset will present “Decentralized Trials – From Guidance to Reality & What’s Left.” Tenaerts is the chief scientific officer of Medable, a cloud computing platform for decentralized clinical trials. Join the online meeting.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Clinical Research 130

Rethinking Clinical Trials

JULY 31, 2023

Building a Study Team for a Pragmatic Clinical Trial Description NIH Collaboratory investigator Dr. Lesley Curtis shares tips for building effective study teams for pragmatic clinical trials.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Clinical Research 130

Drug Discovery World

APRIL 29, 2024

Myeloma Patients Europe (MPE) has launched a new online tool to facilitate the search of clinical trials in myeloma. Solène Clavreul, Head of Medical Education and Scientific Engagement at MPE, said: “Many patients are not aware of clinical trial options.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Medicine 52

BioSpace

APRIL 29, 2024

The FDA has cleared a clinical trial of an ex vivo prime editing candidate in patients with a rare disease, Prime Medicine announced Monday. The technique taps CRISPR technology to rewrite defective genes without breaking DNA double helix strands.

Gene Editing 90

Gene Editing Gene Medicine In-Vivo 90

Pharmaceutical Technology

NOVEMBER 21, 2023

The new scheme will launch in 2024 and aims to save the National Health Service (NHS) £14bn over five years.

Clinical Trials 246

Clinical Trials Clinical Trials Medicine Trials 246

Antidote

OCTOBER 3, 2023

Clinical trials are an integral part of the medical industry, as they are required for any new treatment to be approved. Every medicine used today, whether prescription or over the counter, is a result of the rigorous research process that is a clinical trial — and for these trials to take place, volunteers are vital.

Clinical Trials 119

Clinical Trials Clinical Trials Trials Medicine 119

Rethinking Clinical Trials

DECEMBER 20, 2023

Yet enrollment of ethnic minorities in NIH clinical trials and for trials studying approved devices and drugs remains low. There are several strategies that will help increase diversity in CVD trials. The biggest barrier for CV medicine is the lack of women leaders in CV. We have to change how we are practicing.

Clinical Trials 169

Clinical Trials Clinical Trials Trials Cardiology 169

Rethinking Clinical Trials

MARCH 6, 2024

Schell Professor of Management and Applied Economics MIT Sloan School of Management Slides Keywords Food-as-Medicine, Randomized Clinical Trial, Diabetes Key Points Diabetes is common and costly. Food-as-Medicine observational studies have had a large correlation with improved health. 9% of the U.S.

Clinical Trials 141

Clinical Trials Clinical Trials Medicine Trials 141

Rethinking Clinical Trials

JUNE 27, 2022

A special series of articles addressing pragmatic and virtual trials appears this week in the journal Contemporary Clinical Trials and offers practical approaches to the many challenges clinical trials face. The special issue can be found on the Contemporary Clinical Trials website.

Clinical Trials 141

Clinical Trials Clinical Trials Trials Clinical Research 141

Drug Discovery World

APRIL 4, 2024

EnteroBiotix, a Glasgow, UK based biotechnology company, has dosed the first patient in a clinical trial designed to evaluate EBX-102-02 for the treatment of irritable bowel syndrome (IBS). The trial will be delivered in partnership with the Functional Gut Clinic, a leading IBS diagnosis and treatment centre.

Clinical Trials 98

Clinical Trials Clinical Trials Trials Drugs 98

Pharmaceutical Technology

JUNE 15, 2023

But before pharmaceutical companies can go to market with a breakthrough drug, they need to ensure safety and efficacy through clinical trials. Pharma R&D teams are solving this problem by leveraging the power of artificial intelligence (AI) in clinical trials to save time and money.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Development 130

Pharmaceutical Technology

MARCH 23, 2023

This week, the Medicines and Healthcare products Regulatory Agency (MHRA) is introducing major changes to clinical trial regulation in the UK with expedited timelines at several stages. The MHRA hopes this new framework “will remove obstacles to innovation” and “streamline the regulation of clinical trials” amongst other things.

Clinical Trials 147

Clinical Trials Clinical Trials Regulation Trials 147

Pharmaceutical Technology

APRIL 13, 2023

Following the increased use of telemedicine during the Covid-19 pandemic, the potential of digital technologies in communication, data collection, and analysis has become increasingly realised by patients, healthcare systems, and clinical trial sponsors.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Dermatology 130

ACRP blog

JANUARY 3, 2024

Historically, patient recruitment and retention have been pressing issues within the clinical trial space. Eighty-five percent of trials fail to recruit enough patients, while 80% are delayed due to other factors like participant dropouts.

Clinical Trials 122

Clinical Trials Clinical Trials Trials Medicine 122

XTalks

JANUARY 17, 2024

Given this hotbed of activity, innovation in the space to drive faster decisions and more efficient trials is intense. They discussed the top new trends in oncology trial design that sponsors are either incorporating into clinical trials or need to start planning to include.

Clinical Trials 124

Clinical Trials Clinical Trials Trials Gene Therapy 124

Rethinking Clinical Trials

AUGUST 17, 2022

Michelle Kelsey will present “Inclusion and Diversity in Clinical Trials: Actionable Steps to Drive Lasting Change.” Dr. Bloomfield is an associate professor of medicine and global health and Dr. Kelsey is an assistant professor of medicine at Duke University. Join the online meeting. Join the online meeting.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Medicine 130

Drug Discovery World

MAY 17, 2023

Leveraging historical trial databases has become commonplace in assessing the feasibility of trials in therapeutic areas with a large breadth of clinical development history. EHR data also has a key role to play in designing future clinical trials.

Clinical Trials 52

Clinical Trials Clinical Trials Medicine Trials 52

Rethinking Clinical Trials

AUGUST 7, 2023

Keynote: Diverse Representation Among Clinical Trial Participants: Why It’s Important and How Can We Improve Description Dr. Clyde Yancy presents the keynote session for the Diversity Workshop Grand Rounds series. Biography Clyde W.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Medicine 130

Rethinking Clinical Trials

AUGUST 24, 2022

Areef Ishani of the University of Minnesota will present “The Diuretic Comparison Project: A Large Pragmatic Clinical Trial.” The post August 24, 2022: Diuretic Comparison Project, a Point-of-Care Clinical Trial, to Be Featured in PCT Grand Rounds appeared first on Rethinking Clinical Trials.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Medicine 130

Olympian Clinical Research

MARCH 19, 2024

Clinical trials are essential for advancing medical knowledge and developing new treatments that can improve patient care and outcomes. Participating in a clinical trial is a significant decision that can have profound benefits, not only for the individual participant but also for future patients and the broader medical community.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Clinical Research 52

Rethinking Clinical Trials

APRIL 10, 2024

Corita Grudzen, principal investigator of PRIM-ER In this Friday’s PCT Grand Rounds, Corita Grudzen of the Memorial Sloan Kettering Cancer Center will present “Primary Palliative Care for Emergency Medicine, a Cluster Randomized Stepped-Wedge Trial Across 33 Emergency Departments,” including the results of the PRIM-ER trial.

Trials 169

Trials Clinical Trials Clinical Trials Medicine 169

Rethinking Clinical Trials

FEBRUARY 28, 2024

            Speakers Adrian Hernandez, MD Executive Director, Duke Clinical Research Institute Vice Dean, Duke University School of Medicine Christopher J. The global decentralized clinical trial market is expected to grow at a compound annual growth rate of 30.1% from 2021 to 2026.

Clinical Trials 141

Clinical Trials Clinical Trials Trials Clinical Research 141

Pharmaceutical Technology

APRIL 20, 2023

The face of clinical research is evolving. Rather than bringing patients to sites, study teams are now exploring ways they can bring the trial to patients using a varying combination of direct-to-patient drug shipments, home nursing, video conferencing, and electronic data collection. Everybody got used to doing things remotely.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Nurses 130

XTalks

AUGUST 22, 2023

Recruiting participants is perhaps the most challenging aspect of any clinical trial, regardless of the therapeutic area. Yet this one piece is also the most vital, with a trial’s ability to enroll and retain participants being a key predictor of a study’s future success. What is Clinical Trials For All?

Clinical Trials 97

Clinical Trials Clinical Trials Trials Clinical Research 97

ACRP blog

APRIL 29, 2024

Every May 20th, our community celebrates Clinical Trials Day. It was on this day in 1747 when Dr. James Lind conducted what is largely considered to be the first clinical trial, testing different treatments for scurvy among sailors aboard a ship and reliably proving the therapeutic solution of vitamin C.

Clinical Trials 59

Clinical Trials Clinical Trials Trials Clinical Research 59

XTalks

FEBRUARY 21, 2024

Black participation in clinical trials, and the underrepresentation of minority groups in general in trials, remains low. It is therefore important to work towards increasing Black participation in clinical trials, which begins with understanding the barriers to participation and taking steps to address them.

Clinical Trials 59

Clinical Trials Clinical Trials Trials Life Science 59

Rethinking Clinical Trials

MARCH 27, 2024

Amit Garg and Stephanie Dixon In this Friday’s PCT Grand Rounds, Amit Garg and Stephanie Dixon of Western University’s Schulich School of Medicine and Dentistry will present “Effect of a Multicomponent Intervention to Improve Patient Access to Kidney Transplant and Living Kidney Donation: A Pragmatic, Cluster-Randomized Trial.”

Trials 161

Trials Clinical Trials Clinical Trials Medicine 161

Rethinking Clinical Trials

APRIL 18, 2023

The 5 platform protocols are integrated rather than siloed, disparate studies to achieve efficiencies, allow researchers to rapidly assess targeted therapeutics and pivot as needed to new treatment arms, maximize knowledge gained from patient participation, and to enable cross-trial analysis and accelerated knowledge acquisition.

Clinical Trials 219

Clinical Trials Clinical Trials Trials Immune Response 219

ACRP blog

MARCH 12, 2024

Global Disruptions, Health Equity, and Data Sharing International clinical trials are essential to evaluating the safety and efficacy of new treatments, but their success can be hampered by a variety of challenges. When time is of the essence, how do you scale trials internationally for success? This is a sponsored message.

Clinical Trials 59

Clinical Trials Clinical Trials Trials Regulation 59

Rethinking Clinical Trials

APRIL 4, 2024

The results of the study were published this week in the New England Journal of Medicine. ICD-Pieces, an NIH Collaboratory Trial , was a cluster randomized, pragmatic clinical trial testing an intervention that used an electronic health record–based algorithm and practice facilitators in 141 primary care practices. .

Trials 161

Trials Clinical Trials Clinical Trials Medicine 161

Cloudbyz

DECEMBER 15, 2023

Veterinary clinical trials and human clinical trials share some similarities, but there are key differences owing to the distinct nature of the subjects involved—animals versus humans. The aim is to improve the well-being of animals, enhance veterinary medicine, and contribute to public health (e.g.,

Clinical Trials 64

Clinical Trials Clinical Trials Trials Medicine 64

Drug Discovery World

NOVEMBER 8, 2023

Deepika Khedekar , Associate Centralized Clinical Lead at IQVIA, explains how artificial intelligence could make clinical trials more accurate, accessible and standardised. Tapping into the capabilities of AI One reason AI may accelerate clinical trials is its ability to rapidly process and analyse vast amounts of data.

Clinical Trials 72

Clinical Trials Clinical Trials Trials Drugs 72

BioPharma Reporter

MARCH 5, 2024

Neurogene, a clinical-stage company developing genetic medicines, is expanding its ongoing phase 1/2 clinical trial investigating NGN-401 as a treatment for female pediatric patients with Rett Syndrome.

Clinical Trials 59

Clinical Trials Clinical Trials Gene Therapy Trials 59

XTalks

MAY 19, 2023

Clinical trials play a vital role in advancing patient treatment and medical care. This article delves into ten trends and statistics in the world of clinical trials for 2023. Increasing Number of Registered Clinical Trials As of May 17, 2023, there are 452,604 registered clinical trials globally on ClinicalTrials.gov.

Clinical Trials 97

Clinical Trials Clinical Trials Trials Clinical Research 97