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Risk Assessment for use of Engineered Genetic Materials in Clinical Research

Advarra

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials.

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Scientists engineer safe, virus-resistant E coli for research

Drug Discovery World

In a step forward for genetic engineering and synthetic biology, US researchers have modified E coli bacteria to be immune to infection by all natural viruses tested so far. Genetic engineering The findings build on earlier efforts by genetic engineers, which involved genetically reprogramming E.

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Clean Bench vs Biosafety Cabinet: What’s the Difference?

Advarra

Use of hazardous materials in a clean bench can increase the risk of occupational exposure and contamination of the room in which the work is being done. The hood also blows sterile (HEPA filtered air) from the top down towards the work surface to protect the product from contamination with non-sterile ambient room air. .

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Study confirms the low likelihood that SARS-CoV-2 on hospital surfaces is infectious

Scienmag

A new study by UC Davis researchers confirms the low likelihood that SARS-CoV-2 contamination on hospital surfaces is infectious. The study, published June 24 in PLOS ONE, is the original report on recovering near-complete SARS-CoV-2 genome sequences directly from surface swabs.

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Cryomacs Freezing Bags – A Critical Component in the Successful Delivery of Biological Samples and Therapies

Roots Analysis

Since gene-modified cell therapies rely on genetic alterations made outside of the body of a patient, the corresponding cells must be maintained in a stable state in an ex-vivo setting, for a predetermined amount of time. As a result, during cryopreservation processing and storage, cryomacs bags become fragile and prone to cracking.

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Improving quality control for CAR T cell therapies

Drug Discovery World

Finally, in 2017, after years of improving T cell engineering techniques, the first chimeric antigen receptor (CAR) T cell therapy received FDA approval. Cells from solid tumours are genetically heterogeneous both between and within tumours, making it challenging to identify a single, selective antigen target for treatment.

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COVID-19 Pandemic Coverage

XTalks

CanSino Biologics is developing a vaccine that involves snipping a bit of the virus’ genetic code off and coupling it with a harmless virus to provoke a SARS-CoV-2 immune response. Several laboratories have already shown that they can detect genetic material from the virus in wastewater. Meanwhile, another 3.8