Drug Discovery World

MAY 8, 2024

What you will learn: Raw material validation through whole plasmid sequencing ITR-ITR sequencing of whole AAV genomes and truncation hotspot detection Contamination detection in bioreactor batches through sequencing of residual DNA Register for free here. The event will take place on 13 May, 4PM BST.

Gene Therapy 69

Gene Therapy Gene DNA Genome 69

Drug Discovery World

APRIL 16, 2024

Attendees will hear how library preparation, assessed data quality, and generated important rAAV metrics such as integrity of DNA cargo, truncation events, chimeric transgenes, and levels of co-packaged impurities were performed.

Packaging 52

Packaging Packaging Genome Genomics 52

Drug Discovery World

MAY 1, 2024

What you will learn: Raw material validation through whole plasmid sequencing ITR-ITR sequencing of whole AAV genomes and truncation hotspot detection Contamination detection in bioreactor batches through sequencing of residual DNA Register for free here. The event will take place on 13 May, 4PM BST.

Packaging 52

Packaging Packaging Genome Genomics 52

Advarra

JULY 28, 2022

Use of hazardous materials in a clean bench can increase the risk of occupational exposure and contamination of the room in which the work is being done. The hood also blows sterile (HEPA filtered air) from the top down towards the work surface to protect the product from contamination with non-sterile ambient room air. .

Contamination 52

Contamination Biohazard Biohazard Production 52

Drug Discovery World

APRIL 24, 2024

What you will learn: Raw material validation through whole plasmid sequencing ITR-ITR sequencing of whole AAV genomes and truncation hotspot detection Contamination detection in bioreactor batches through sequencing of residual DNA Register for free here. The event will take place on 13 May, 4PM BST.

Genome 52

Genome Genomics DNA Gene Therapy 52

Roots Analysis

APRIL 15, 2024

Over the years, these large molecules have demonstrated promising therapeutic outcomes in the treatment of myriad of chronic and challenging disorders, including autoimmune disorders, infectious diseases, genetic disorders, and oncological disorders.

Manufacturing 40

Manufacturing Production Contract Manufacturing Contamination 40

Scienmag

JUNE 25, 2021

A new study by UC Davis researchers confirms the low likelihood that SARS-CoV-2 contamination on hospital surfaces is infectious. The study, published June 24 in PLOS ONE, is the original report on recovering near-complete SARS-CoV-2 genome sequences directly from surface swabs.

Contamination 41

Contamination Genome Genomics Research 41

XTalks

JULY 26, 2021

Those who seek shorter ingredient lists and cleaner labels may object to plant-based meat due to the many additives and genetically modified proteins that tend to be crucial components of its formulation. Related: Is Cell-Based Fish the Next Big Food Innovation? Subject to Microbial Growth. Dietary and nutritional factors.

Protein 98

Protein Contamination Allergies Bacteria 98

Roots Analysis

OCTOBER 24, 2023

They consist of two or more amino acids and are synthesized naturally from transcription of a sequence of genetic code. This precaution is taken to prevent any potentially harmful contaminant from escaping the production area. This is in contrast to the containment requirements at manufacturing facilities of traditional APIs.

Manufacturing 40

Manufacturing Hormones Contamination Containment 40

Roots Analysis

SEPTEMBER 20, 2023

Cell therapies are based on the premise that the patient’s own cells ( autologous ), or those from a healthy donor ( allogeneic ), can be genetically re-programmed to combat various diseases. Contamination is a key concern when it comes to manufacturing cell therapy products.

Manufacturing 40

Manufacturing Production Contamination Gene Therapy 40

The Pharma Data

JANUARY 6, 2021

Two boys, a 23-month-old and a 6-year-old, developed lung cancers that proved an exact genetic match to cervical cancers within their mothers at the time of birth, Japanese researchers report. In both cases, doctors used genetic testing to positively link the mothers’ cervical cancers to the lung cancers in their sons.

Vaccination 52

Vaccination Vaccine Doctors Doctor 52

Cloudbyz

NOVEMBER 3, 2021

Before deploying collected samples for a project, small portions from those samples are retained as a precautionary measure, to account for any potential destruction or contamination of the originally designated portions of the samples. Let’s use the easiest example of a sample.

Biobanking 52

Biobanking Clinical Research Contamination Research 52

Drug Discovery World

FEBRUARY 28, 2023

As we turn our focus to new potential applications and disease areas for the platform, scientists and companies must consider the potential life-saving impact on rare, inherited diseases, says Archana Gupta , PhD, staff scientist in genetic sciences at Thermo Fisher Scientific.

Genetics 52

Genetics Genetic Analysis Vaccination Vaccine 52

FDA Law Blog

MAY 19, 2023

The submission will need to include a “detailed description of a protocol for continuous monitoring, identification, and handling of genetic mutations and/or novel isolates or strains.” Continuous Monitoring and Post Market Reporting Special Controls Within the Special Control for Risk Analysis are details regarding continuous monitoring.

Reagent 40

Reagent Genetics Contamination Marketing 40

XTalks

FEBRUARY 26, 2021

The controversy continues over profits, privacy of genetic information extracted from the cells and racial inequities in access to research and healthcare. It wasn’t until the early 1970s when large numbers of other cell lines were found to be contaminated with HeLa in some labs that an investigation was launched. Henrietta Lacks.

Scientist 69

Scientist Research Genetics Cosmetics 69

Pharmaceutical Technology

FEBRUARY 3, 2023

With scientists fervently developing mRNA vaccines, nucleic acid therapeutics, and viral vector-based gene therapies, clinicians are set to have a growing number of tools available to treat a wide range of conditions, from infectious diseases to genetic disorders and more. Biores Open Access. 2020 Oct 16;9(1):219-228. doi: 10.1089/biores.2020.0031.

Genome 244

Genome Genomics Medicine Gene Therapy 244

XTalks

NOVEMBER 7, 2022

However, Dr. Bahassi reported that the selection of CTCs using this method is often not very efficient and the CTC population is usually highly contaminated with leukocytes. This is a negative CTC selection technique because CD45 markers are used to remove white blood cells from the sample, leaving CTCs behind.

Clinical Trials 98

Clinical Trials Clinical Trials Trials FDA Approval 98

The Pharma Data

NOVEMBER 10, 2020

It is important to note that the E.coli strain identified in this outbreak is not genetically related to either of the E. 15 or 16 due to possible contamination with E. coli O157:H7 outbreaks that occurred in 2019 resulting in contamination of romaine lettuce in the Salinas Valley growing area. . SILVER SPRING, Md. ,

Contamination 52

Contamination Packaging Packaging Production 52

Drug Discovery World

AUGUST 10, 2022

Cells from solid tumours are genetically heterogeneous both between and within tumours, making it challenging to identify a single, selective antigen target for treatment. Although this type of contamination has not yet been reported in humans, RCVs can form rapidly growing T cell neoplasms, another type of cancer.

Manufacturing 98

Manufacturing Gene Genome Genomics 98

Roots Analysis

SEPTEMBER 18, 2023

Since gene-modified cell therapies rely on genetic alterations made outside of the body of a patient, the corresponding cells must be maintained in a stable state in an ex-vivo setting, for a predetermined amount of time. As a result, during cryopreservation processing and storage, cryomacs bags become fragile and prone to cracking.

Engineer 52

Engineer Containment In-Vivo Production 52

Drug Discovery World

AUGUST 16, 2022

Disparities resulting from genetic, environmental, social, and economic factors increase cancer risks in certain subpopulations, and negatively affect their health outcomes. Cancer risks also increase in areas with water contaminants or polluted air. Cancer health disparities and underlying contributing factors .

Research 52

Research Clinical Trials Clinical Trials Trials 52

The Pharma Data

MAY 13, 2021

every day are contaminated with at LEAST ONE TOXIC ingredient. The REAL problem lies in the fact that most of the foods we eat today have been Genetically Modified. These ingredients can be harmful and even LIFE THREATENING. These ingredients are responsible for putting your health at risk. million deaths in the United States alone.

Production 52

Production Containment Genetics Doctors 52

Drug Discovery World

FEBRUARY 8, 2023

The threat of empty capsids Capsids are the protein shell that would usually enclose the genetic material of a virus. Partially-filled capsids may also be present, and contain packaged process-related impurities or truncated genetic material. In AAV therapeutics, empty capsids are those that are not packaged with the therapeutic DNA.

Gene Therapy 52

Gene Therapy Gene Antibody Production 52

Drug Discovery World

MAY 11, 2023

In addition, there are other sources of protein contamination, such as from cell culture medium supplements — for example, bovine serum albumin.” coli, and Pichia cells. These host cells alone contain over a thousand HCPs.

Production 52

Production Gene Protein Vaccination 52

Pharmaceutical Technology

APRIL 27, 2023

When combined with rapid advancement in delivery technologies, mRNA has the potential to lead to breakthroughs in the development of tailored treatment approaches in a wide range of indications from cancer to rare genetic disorders while enabling rapid responses to emerging threats.

Manufacturing 130

Manufacturing RNA Contamination Vaccination 130

XTalks

SEPTEMBER 14, 2020

CanSino Biologics is developing a vaccine that involves snipping a bit of the virus’ genetic code off and coupling it with a harmless virus to provoke a SARS-CoV-2 immune response. Several laboratories have already shown that they can detect genetic material from the virus in wastewater.

Vaccination 92

Vaccination Vaccine Antibody Life Science 92