Roots Analysis

FEBRUARY 26, 2024

In fact, the share of biologics in the overall pharmaceutical contract manufacturing market has increased from 16% in 2006 to over 25% in 2017. Having reported over 70% increase in revenues over the past 5-6 years, the market for biologically derived products is currently estimated to be worth more than USD 200 billion.

Drug Delivery Systems 52

Drug Delivery Systems Drug Delivery Drugs Contract Manufacturing 52

Roots Analysis

JANUARY 23, 2024

However, there are several challenges and complexities that impact both product yield and purity associated with the peptide synthesis and purification of complex long-chain macromolecules. Additionally, peptides may offer enhanced absorption compared to proteins, swiftly entering the bloodstream by easily permeating the skin and intestines.

Development 40

Development Contract Manufacturing Drugs Manufacturing 40

Roots Analysis

FEBRUARY 27, 2024

Currently, product licensing agreements, technology licensing agreements, research and development agreements and clinical trial agreements are the common types of partnerships inked by developers that are currently focused on the development of ADCs pipeline.

Antibody 52

Antibody Licensing Licensing Contract Manufacturing 52

Pharmaceutical Technology

JULY 29, 2022

Pfizer (New York, New York) and Moderna’s (Cambridge, Massachusetts) Omicron-specific Covid-19 vaccines are in late-stage development, have demonstrated good efficacy against the variant and will likely be available to the public later this year to provide an additional booster and increase demand for injectable manufacturing.

Manufacturing 130

Manufacturing Vaccination Vaccine Packaging 130

Roots Analysis

OCTOBER 24, 2023

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe.

Manufacturing 40

Manufacturing Hormones Contamination Containment 40

Roots Analysis

MARCH 9, 2022

In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines, and gene therapies), by the US FDA, have steadily risen. In fact, over 8,000 biological pharmaceutical products are currently under clinical investigation worldwide. . Capacity Analysis.

Manufacturing 52

Manufacturing Marketing Contract Manufacturing Protein 52

pharmaphorum

DECEMBER 18, 2020

Approval in lupus nephritis is expected to push the product above the $1 billion threshold and into blockbuster sales territory. Benlysta binds and neutralises the B cell survival factor BAFF, while rituximab targets CD20, a protein found on the surface of B cells.

FDA Approval 99

FDA Approval Contract Manufacturing Sales Trials 99

Roots Analysis

AUGUST 8, 2023

Disposable bioreactors have transformed the process of conventional biomanufacturing, and their adoption is increasing rapidly for production of various biologics, such as antibody, recombinant proteins, cell and gene therapy. As a result, the products are also removed continuously. What is Single-use Bioreactors?

Manufacturing 52

Manufacturing Production Marketing Gene Therapy 52

Roots Analysis

FEBRUARY 18, 2022

In the 20 th century, major research went into discovery of a therapeutic class with the primary purpose of interfering with the RNA expression linked to disease causing proteins, nowadays classified as oligonucleotides. These contract service providers are actively entering into strategic collaborations to augment their existing portfolios.

Contract Manufacturing 52

Contract Manufacturing Manufacturing Drug Delivery Systems RNA 52

XTalks

FEBRUARY 27, 2024

TIL vs CAR T-Cell Therapies While CAR T-cell therapies involve inserting a CAR engineered to target a specific cancer cell protein into a patient’s T cells, TIL-based T-cell therapies like Amtagvi involve separating TILs from a patient’s tumor (in autologous therapies) and expanding them ex vivo.

FDA Approval 52

FDA Approval Manufacturing In-Vivo Trials 52

Roots Analysis

MARCH 13, 2022

In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines and gene therapies), by the US FDA, have steadily risen. In fact, over 8,000 biological pharmaceutical products are currently under clinical investigation worldwide.

Manufacturing 52

Manufacturing Drug Delivery Marketing Drug Delivery Systems 52

XTalks

JANUARY 23, 2024

This venture also led me to identify a gap in the market for contract manufacturing of recombinant proteins. Our approach is informed by historical precedents in growth hormone product reviews by the FDA, guiding our preparations for the Phase III study.

Development 72

Development Hormones Drugs Trials 72

The Pharma Data

OCTOBER 6, 2021

Adds 185,000 litres of biopharmaceutical production capacity High degree of digitalization and automation through smart technologies and artificial intelligence applications Multi-product setup enables production of a large variety of molecule formats Investment of more than 700 million EUR, creating 500 new jobs.

Production 52

Production Contract Manufacturing Manufacturing Branding 52

The Pharma Data

MARCH 22, 2022

Pfizer continues to invest to support the manufacturing and distribution of PAXLOVID, including exploring potential contract manufacturing options. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus.

In-Vitro 52

In-Vitro Contract Manufacturing Manufacturing Development 52

Pfizer

DECEMBER 13, 2021

After Pfizer and BioNtech signed a letter of intent in March 2020 to work together on a vaccine, two Pfizer facilities were swiftly selected for developing the processes and manufacturing the product at an industrial scale. Within those first 100 days, the first manufacturing run was a success. The work continues.

Manufacturing 52

Manufacturing Vaccination Vaccine Production 52

XTalks

APRIL 11, 2024

Moreover, rather than producing antibodies, the cancer cells produce abnormal proteins that can cause complications. J&J has ambitious plans for Carvykti as it is looking to target peak product sales of over $5 billion for the therapy. In 2023, the drug’s sales totalled $500 million.

FDA Approval 52

FDA Approval Manufacturing Trials Clinical Trials 52

Roots Analysis

FEBRUARY 13, 2023

Messenger ribonucleic acid (mRNA) is a single-stranded molecule, which carries coding sequence and plays a prominent role in protein synthesis. It transfers genetic information form to DNA to ribosomes, a specialized structure, or organelle, which decodes genetic information into a protein.

Manufacturing 52

Manufacturing Drug Delivery Systems Genetic Engineering RNA 52

The Pharma Data

DECEMBER 23, 2020

Cellular (T cell) response were observed to multiple regions of the spike protein including the RBD region. . The 1.0 mg and 2.0 mg dose group both demonstrated seroconversion in 95% of the subjects, respectively, with 78% demonstrating neutralizing antibodies in the 1.0 mg dose group. About INOVIO.

DNA 40

DNA Vaccination Vaccine Immune Response 40

XTalks

FEBRUARY 11, 2021

Pfizer is planning to reduce that time to an average of 60 days, cutting production time by almost 50 percent. For Pfizer-BioNTech’s vaccine, a batch consists of between one and three million doses of vaccine per production run. This in light of Pfizer having upped its production goal to two billion COVID-19 vaccine doses this year.

Manufacturing 52

Manufacturing Vaccination Vaccine DNA 52

Roots Analysis

OCTOBER 3, 2023

Bioreactors and fermenters are complex systems used across numerous sectors of the industry, for the production of pharmaceuticals, nutraceuticals, food, and beverages. These systems provide controlled conditions for cell growth by providing optimum nutrient supply, and oxygenation, enabling the production of biologics.

Vaccination 40

Vaccination Vaccine Production Manufacturing 40

Roots Analysis

JANUARY 24, 2024

Continuous manufacturing process involves the production of pharmaceutical drug substance in a single run, while operating 24×7. In this process, the drug is developed from its base ingredients / raw materials and processed to the final product in one facility, without any hold time.

Manufacturing 40

Manufacturing Contract Manufacturing Production Marketing 40

Pharmaceutical Technology

APRIL 24, 2023

“Biologics products may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.

Contract Manufacturing 130

Contract Manufacturing Manufacturing Protein Sales 130

The Pharma Data

MAY 4, 2021

Multiple innovative and biosimilar products across our portfolio delivered growth, demonstrating the strength of our business and the depth and breadth of our growth drivers. This guidance may be adjusted in the future as additional contracts are executed. Hospital products, which grew 10% operationally to $2.3

Vaccination 40

Vaccination Vaccine Production Sales 40

XTalks

NOVEMBER 11, 2021

The COVID-19 vaccine patent is for the specific genetic sequence of the spike protein used in the Spikevax vaccine. But it remains to be seen how Moderna will achieve the goal of producing more doses as it hasn’t announced any new partnerships with contract manufacturers for increasing production of the vaccine.

Vaccination 97

Vaccination Vaccine Scientist Contract Manufacturing 97

Pharmaceutical Technology

DECEMBER 15, 2022

The Singapore Government has launched Biologics Pharma Innovation Programme Singapore (BioPIPS), which aims to increase the country’s manufacturing capacity for biologics, including recombinant proteins and vaccines. Most of the approximately 30 contract manufacturing facilities in Singapore are foreign-owned.

Manufacturing 264

Manufacturing Vaccination Vaccine Production 264