Roots Analysis

APRIL 15, 2024

These complex entities, such as antibodies, antibody drug conjugates, cell therapies, gene therapies, and therapeutic proteins, are highly specific molecules that are designed to precisely target biomarkers associated with a particular disease pathway.

Manufacturing 40

Manufacturing Production Contract Manufacturing Contamination 40

Roots Analysis

JANUARY 23, 2024

Moreover, these short chains of amino acids, distinct from proteins in their shorter length, serve as essential building blocks for various scientific investigations. Additionally, peptides may offer enhanced absorption compared to proteins, swiftly entering the bloodstream by easily permeating the skin and intestines.

Development 40

Development Contract Manufacturing Drugs Manufacturing 40

pharmaphorum

AUGUST 7, 2020

Under the terms of the agreement Pfizer will become one of several external partners who manufacture the investigational treatment for the disease. Pfizer will provide contract manufacturing services at its facility in McPherson, Kansas, to supply the drug to Gilead.

Manufacturing 117

Manufacturing Contract Manufacturing Protein Allergies 117

Pharmaceutical Technology

JULY 29, 2022

Pfizer (New York, New York) and Moderna’s (Cambridge, Massachusetts) Omicron-specific Covid-19 vaccines are in late-stage development, have demonstrated good efficacy against the variant and will likely be available to the public later this year to provide an additional booster and increase demand for injectable manufacturing.

Manufacturing 130

Manufacturing Vaccination Vaccine Packaging 130

Roots Analysis

FEBRUARY 26, 2024

In fact, the share of biologics in the overall pharmaceutical contract manufacturing market has increased from 16% in 2006 to over 25% in 2017. Biologics constitute a majority of the top selling drugs and represent one of the fastest growing segments of the overall pharmaceutical industry.

Drug Delivery Systems 52

Drug Delivery Systems Drug Delivery Drugs Contract Manufacturing 52

XTalks

JANUARY 29, 2021

They are both checkpoint inhibitors targeted towards programmed cell death protein 1 (PD-1 inhibitors), a protein that is responsible for downregulating the immune system and preventing it from killing cancer cells. As both products target the same pathway, they naturally compete in many indications (Table 1).

Clinical Trials 104

Clinical Trials Clinical Trials Production Trials 104

pharmaphorum

NOVEMBER 5, 2020

After infusion, the nanoparticles are taken up by tumour cells, says Genprex, and leads to the expression of the TUSC2 gene into a protein that reprograms them to die. The post Genprex cancer gene therapy paired with AZ, Merck lung cancer drugs appeared first on.

Gene Therapy 98

Gene Therapy Gene Drugs Contract Manufacturing 98

Roots Analysis

FEBRUARY 18, 2022

In the 20 th century, major research went into discovery of a therapeutic class with the primary purpose of interfering with the RNA expression linked to disease causing proteins, nowadays classified as oligonucleotides. These contract service providers are actively entering into strategic collaborations to augment their existing portfolios.

Contract Manufacturing 52

Contract Manufacturing Manufacturing Drug Delivery Systems RNA 52

pharmaphorum

DECEMBER 18, 2020

GSK has been ramping up its manufacturing for Benlysta in anticipation of the new approval, including in-house capacity at its Rockville plant in Maryland, US, and through a contract manufacturing deal with Samsung Biologics. The anti-CD20 mechanism could also lead to some competition for GSK in SLE and lupus nephritis.

FDA Approval 89

FDA Approval Contract Manufacturing Sales Trials 89

Roots Analysis

MARCH 9, 2022

In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines, and gene therapies), by the US FDA, have steadily risen. Biopharmaceutical Excipient Manufacturing Market.

Manufacturing 52

Manufacturing Marketing Contract Manufacturing Protein 52

Roots Analysis

OCTOBER 24, 2023

The ADCs bind to specific proteins or peptides in cancer cells with very high specificity and efficacy influencing the biological functions. A molecule having 2-50 amino acids is considered as peptide whereas, group of peptides are responsible for forming a protein.

Manufacturing 40

Manufacturing Hormones Contamination Containment 40

pharmaphorum

JANUARY 6, 2021

RNAi uses small RNA molecules to bind to messenger RNA, which is responsible for synthesising proteins, and either destroy it or recruit other cellular factors that regulate its activity. The nomination of a first candidate in the collaboration that will advance into development triggers a $2.5

Gene Silencing 60

Gene Silencing Gene RNA Contract Manufacturing 60

XTalks

FEBRUARY 27, 2024

TIL vs CAR T-Cell Therapies While CAR T-cell therapies involve inserting a CAR engineered to target a specific cancer cell protein into a patient’s T cells, TIL-based T-cell therapies like Amtagvi involve separating TILs from a patient’s tumor (in autologous therapies) and expanding them ex vivo.

FDA Approval 52

FDA Approval Manufacturing In-Vivo Trials 52

XTalks

JANUARY 23, 2024

This venture also led me to identify a gap in the market for contract manufacturing of recombinant proteins. Together, we developed the world’s first growth hormone receptor antagonist, Somavert (pegvisomant), targeting acromegaly.

Development 72

Development Hormones Drugs Trials 72

Roots Analysis

MARCH 13, 2022

In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines and gene therapies), by the US FDA, have steadily risen. Over the years, the rising popularity of biologics has led to a paradigm shift in the healthcare industry.

Manufacturing 52

Manufacturing Drug Delivery Marketing Drug Delivery Systems 52

Roots Analysis

AUGUST 8, 2023

Disposable bioreactors have transformed the process of conventional biomanufacturing, and their adoption is increasing rapidly for production of various biologics, such as antibody, recombinant proteins, cell and gene therapy.

Manufacturing 52

Manufacturing Production Marketing Gene Therapy 52

XTalks

APRIL 11, 2024

Moreover, rather than producing antibodies, the cancer cells produce abnormal proteins that can cause complications. In last month’s call, Legend CEO Ying Huang, PhD, shared that the partners are aiming to increase manufacturing capacity at their New Jersey plant.

FDA Approval 52

FDA Approval Manufacturing Trials Clinical Trials 52

The Pharma Data

MARCH 22, 2022

Pfizer continues to invest to support the manufacturing and distribution of PAXLOVID, including exploring potential contract manufacturing options. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus.

In-Vitro 52

In-Vitro Contract Manufacturing Manufacturing Production 52

Drug Discovery World

DECEMBER 14, 2023

The Institute has particular strengths in understanding how cancer hijacks the cell’s energy factories and how it manipulates the body to provide the resources it needs to grow and spread, like protein scaffolding and blood vessels. Discoveries in these areas will identify new treatments which will become the cancer drugs of the future.”

Drugs 75

Drugs Life Science Research Scientist 75

The Pharma Data

OCTOBER 6, 2021

Hightech production facility In the LSCC, Boehringer Ingelheim will produce biopharmaceuticals for its own product portfolio as well as for third-party contract manufacturing. Biopharmaceutical Contract Manufacturing Boehringer Ingelheim is one of the leading manufacturers of biopharmaceuticals.

Production 52

Production Contract Manufacturing Manufacturing Branding 52

Roots Analysis

FEBRUARY 13, 2023

Messenger ribonucleic acid (mRNA) is a single-stranded molecule, which carries coding sequence and plays a prominent role in protein synthesis. It transfers genetic information form to DNA to ribosomes, a specialized structure, or organelle, which decodes genetic information into a protein.

Manufacturing 52

Manufacturing Drug Delivery Systems Genetic Engineering RNA 52

Pfizer

DECEMBER 13, 2021

In separate countries, joined by a common purpose, they worked to formulate lipid nanoparticles - a notoriously tricky process - that would protect and guide the mRNA, which programs cells to produce antibodies to fight off COVID-19 by introducing a protein found on the surface of the virus.

Manufacturing 52

Manufacturing Vaccination Vaccine Production 52

pharmaphorum

NOVEMBER 12, 2020

It added that AAV-mediated gene therapy can “drive a fundamental change in how diseases are treated with the ability to remove or add disease-related proteins with a single treatment.”. Handl has also tapped into the development and manufacturing capabilities at Novasep, a contract manufacturing organisation (CMO) also based in Belgium.

Gene Therapy 52

Gene Therapy Gene Manufacturing Contract Manufacturing 52

The Pharma Data

DECEMBER 23, 2020

Cellular (T cell) response were observed to multiple regions of the spike protein including the RBD region. . The 1.0 mg and 2.0 mg dose group both demonstrated seroconversion in 95% of the subjects, respectively, with 78% demonstrating neutralizing antibodies in the 1.0 mg dose group.

DNA 40

DNA Vaccination Vaccine Immune Response 40

Drug Discovery World

SEPTEMBER 6, 2022

Indeed, the growth of the cell and gene therapy market, coupled with the demand that the pandemic placed on manufacturing capacity, means the industry faces shortages of these crucial materials. This genetic vaccination is an extension of the gene therapy modality,” says Francis. .

Gene Therapy 52

Gene Therapy Gene Manufacturing Medicine 52

XTalks

FEBRUARY 11, 2021

The drugmaker is targeting various steps in the manufacturing process, beginning right at the DNA stage, which is required as the template from which the mRNA for the SARS-CoV-2 spike protein in the vaccine is made. The USA Today got a peek into the process of making Pfizer’s mRNA vaccine and outlined the details in its report.

Manufacturing 52

Manufacturing Vaccination Vaccine DNA 52

Drug Discovery World

FEBRUARY 2, 2023

RRx-001 directly and irreversibly binds to a specific amino acid cysteine residue on a protein complex called the NLRP3 inflammasome, which serves as the “on switch” for inflammation.

Manufacturing 52

Manufacturing Clinical Trials Clinical Trials Drugs 52

Roots Analysis

OCTOBER 3, 2023

For instance, In March 2022, Mabion ordered four Kuhner Orbital Shaken Bioreactors (OSB) for contract manufacturing of the first protein-based COVID 19 vaccine developed by Novavax.

Vaccination 40

Vaccination Vaccine Production Manufacturing 40

Pharmaceutical Technology

APRIL 24, 2023

“Biologics products may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.

Contract Manufacturing 130

Contract Manufacturing Manufacturing Protein Sales 130

Roots Analysis

JANUARY 24, 2024

Presently, close to 60 manufacturers have adopted end to end continuous manufacturing and semi-continuous manufacturing process for various types of biologics, including antibodies, enzymes, proteins / peptides, vaccines and viral vectors.

Manufacturing 40

Manufacturing Contract Manufacturing Production Marketing 40

XTalks

NOVEMBER 11, 2021

The COVID-19 vaccine patent is for the specific genetic sequence of the spike protein used in the Spikevax vaccine. But it remains to be seen how Moderna will achieve the goal of producing more doses as it hasn’t announced any new partnerships with contract manufacturers for increasing production of the vaccine.

Vaccination 98

Vaccination Vaccine Scientist Contract Manufacturing 98

The Pharma Data

MAY 4, 2021

billion, primarily driven by Pfizer CentreOne, Pfizer’s contract manufacturing operation, reflecting sales of legacy Upjohn products to Viatris (4) and remdesivir to Gilead Sciences Inc., Hospital products, which grew 10% operationally to $2.3 down 7%, which reflects relatively stable U.S.

Vaccination 40

Vaccination Vaccine Production Sales 40

Pharmaceutical Technology

DECEMBER 15, 2022

The Singapore Government has launched Biologics Pharma Innovation Programme Singapore (BioPIPS), which aims to increase the country’s manufacturing capacity for biologics, including recombinant proteins and vaccines. Most of the approximately 30 contract manufacturing facilities in Singapore are foreign-owned.

Manufacturing 264

Manufacturing Vaccination Vaccine Production 264