Medical Xpress

MARCH 22, 2023

Fiber intake is associated with a lower risk of developing cognitive decline in those old people with the apolipoprotein E ApoE ε4 genotype, regarded as a genetic risk factor linked to the development of Alzheimer's disease.

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Genotype Pharmacy Genetics Development 75

Drug Discovery World

FEBRUARY 19, 2024

The partners will first develop and validate genotypic diagnostics that provide clinicians with an accurate view of a patient’s risk of disease; then, using the molecular profile of their underlying disease mechanisms, report back effective prescribing decisions and drug discovery opportunities to improve patient outcomes.

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Genotype Engineer Clinical Trials Clinical Trials 52

Scienmag

JUNE 23, 2022

Orofacial clefts (OFCs) are congenital birth defects where the independently derived facial primordia that form the orofacial complex fail to fuse properly during embryonic development. 170 GWAS derived SNPs were genotyped on 3000 replication samples from participants in Ethiopia, Ghana, and […].

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Genotype Genome Genomics Development 58

Scienmag

AUGUST 25, 2020

Credit: Iliana Baums, Penn State Coral conservation efforts could get a boost from a newly developed genotyping “chip”–the first of its kind for corals.

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Genotype Genetics Development Research 66

Scienmag

JANUARY 13, 2021

To discover these associations, researchers need to compare the genomes of many individuals at millions of genetic locations or markers, and therefore require cost-effective genotyping technologies. A new statistical method, developed […].

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Genome Genomics Genotype Genetics 57

Worldwide Clinical Trials

FEBRUARY 6, 2023

The best course of action will depend on many variables, such as the disease or population being studied and the genotype/phenotype relationship, risk, and impact on care. Obtaining appropriate assistance to facilitate planning up front for the complexities involved will save sponsors time and effort in the long run.

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Genetics Clinical Trials Clinical Trials Genotype 130

pharmaphorum

JANUARY 18, 2023

Pharmaceutical companies and biotechs are also adapting their approaches, launching patient finding and engagement programmes that can start years before clinical trials begin and allow them to run ‘recontact by genotype’ studies that the Resilience Project would have liked to do. Giving participants something in return. About the author.

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Genetic Disease Genetics Research Genome 94

BioTech 365

AUGUST 17, 2020

ETD002 is a novel TMEM16A chloride channel potentiator Therapy applicable to all cystic fibrosis patients, independent of genotype BRIGHTON, England–(BUSINESS WIRE)–Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives … Continue reading (..)

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Genotype Trials Development 52

Pharmaceutical Technology

JUNE 6, 2023

The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress. Pharma Mar Overview Pharma Mar discovers, develops and markets marine-derived drugs to treat cancer. Its development pipeline includes PM14 for solid tumors, among others.

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Hormones In-Vitro Genotype Bacteria 100

Pharmaceutical Technology

DECEMBER 15, 2022

Since HFC replacement therapy is the mainstay of treatment for CFD, increased development of more innovative fibrinogen-based therapies will benefit both the CFD population and patients experiencing AFD. CFD is an extremely rare disease in which many patients are often asymptomatic and do not require treatment.

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Marketing Production Genotype Development 130

Drug Discovery World

JULY 3, 2023

PrecisionLife and the University of Oxford have signed a data access agreement to license the Oxford Endometriosis Gene (OXEGENE) dataset to develop new personalised treatments for endometriosis patients. We hope that the analysis of our data will lead to the development of precision medicines to improve the lives of patients.”

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Genetics Genotype Medicine Licensing 52

Delveinsight

DECEMBER 13, 2020

Due to hepatitis C, most people develop cirrhosis, or scarring of the liver, before liver cancer; about 5–25% of patients with chronic hepatitis C develop cirrhosis over 10–20 years. Research and development in Hepatitis. 2b) was developed to maintain a steady level of an active drug and reduce the frequency of administration.

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Genotype FDA Approval DNA Drugs 52

Bioengineer

JANUARY 16, 2024

Often, the loss of T790M is associated with the development of alternative competitive resistance mechanisms. Importantly, a triple mutant scenario with EGFR L858R/T790M/C797S or EGFRexon19del/T790M/C797S genotype may occur in patients with T790-positive NSCLC receiving osimertinib in second or later lines.

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Genome Genomics Protein In-Vitro 119

Drug Discovery World

MAY 22, 2023

The collaboration will accelerate findings by PrecisionLife working with the Motor Neurone Disease Association and leading clinicians at King’s College London and the University of Sheffield to analyse genotyped patient data and find novel genetic insights into the disease.

Medicine 52

Medicine Genotype Genetics Clinical Trials 52

XTalks

APRIL 3, 2024

This development, announced earlier this week, introduces a significant twist in the ongoing saga of the H5N1 virus , which has been affecting birds globally and in the US since early 2022. genotype in wild birds from November 2023. The detection of HPAI in dairy cows marks a concerning development for the US dairy industry.

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Genotype Contamination Bacteria Development 45

pharmaphorum

JANUARY 21, 2022

The findings have been submitted to the Genotype-to-Phenotype National Virology Consortium (G2P-UK), the New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) and the Joint Committee on Vaccination and Immunisation (JCVI).

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Antibody Vaccination Vaccine Genotype 113

Roots Analysis

APRIL 28, 2024

Factors Contributing to Kidney Diseases There are several factors which contribute to an increased risk of developing kidney diseases, including genetic causes and underlying metabolic causes ( diabetes, high blood pressure, aging and obesity ), which when combined with other factors increase the risk of developing kidney diseases.

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Genetics Genotype Development FDA Approval 40

pharmaphorum

JANUARY 24, 2023

Drug development has long been an issue for the pharma industry, due to the expense and the high failure rate of potential treatments. Ben Hargreaves finds that the vast amount of genetic data that exists today could help provide a faster, more targeted way of developing new drug candidates.

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Genetics Drugs Genome Project Biobanking 96

The Pharma Data

NOVEMBER 18, 2020

18, 2020 — Genetic variants in some patients with inflammatory bowel disease (IBD) are associated with a significantly increased risk for developing thromboembolic disease (TED), according to a study published online Oct. WEDNESDAY, Nov. 21 in Gastroenterology. Takeo Naito, Ph.D.,

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Genetics Genotype Genome Genomics 52

pharmaphorum

JANUARY 29, 2019

How the shift towards cancer as a phenotype/genotype is being applied in clinical trials and how they are run •What are co-clinical trials and why could they hold the key to answering unmet need in cancer treatment and beyond into broader drug development? What are the implications from these changes for clinical trials?

Medicine 52

Medicine Genome Genomics Clinical Trials 52

The Pharma Data

NOVEMBER 2, 2020

(NASDAQ:ADIL; ADILW) , a clinical-stage biopharmaceutical company focused on the development of treatments for addictions, today provided an update on its landmark ONWARD Phase 3 pivotal trial. Adial Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the development of treatments for addictions.

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Trials Genotype Marketing Production 52

Drug Discovery World

FEBRUARY 27, 2024

DDW Editor Reece Armstrong speaks to Ron Alfa , CEO & Co-founder at NOETIK, about the company’s mission to utilise artificial intelligence (AI) and spatial biology to develop better immunotherapies for cancer patients. Ron A : Our mission is to discover and develop new therapeutics to patients with diverse cancers.

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Genome Genomics Genotype Medicine 52

Drug Discovery World

SEPTEMBER 20, 2022

Each circle represents a disease-associated SNP genotype, edges represent their co-association in patients in disease signature(s), and colours represent distinct patient sub-populations. On the right: the same disease architecture view coloured to show the critical SNPs associated with each community.

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Genetics Biobanking Genotype Gene 52

XTalks

MARCH 29, 2021

Grantz, of the Division of Intramural Population Health Research at NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development. The results did not differ based on fast or slow caffeine metabolism genotype. Related: Maternal Antibodies: How Allergies Can be Passed from Mothers to Children.

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Genotype Allergies Hormones Research 98

Drug Discovery World

NOVEMBER 23, 2023

Artificial Intelligence (AI) has become a popular buzzword in the drug discovery and development lexicon but not all approaches to AI-driven drug discovery produce meaningful insights that translate into real compounds which ultimately demonstrate clinical efficacy in human trials.

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Biobanking Drugs Medicine Genome 59

The Pharma Data

SEPTEMBER 8, 2021

TIB Molbiol excels in ultra-rapid assay development for emerging infectious disease, strongly demonstrated during the COVID-19 pandemic. For example, in 2001 with anthrax and 2003 with SARS-CoV1, TIB Molbiol demonstrated their ability to develop PCR assays for the detection of new pathogens within days.

Genotype 52

Genotype Reagent Genetics Research 52

XTalks

APRIL 29, 2021

While ARV-based treatments work well to keep the virus suppressed and patients healthy — some for many years — resistance to one or more drugs in a treatment regimen can develop in some patients. HIV drug resistance occurs when virions develop mutations that make them less susceptible to given drugs. Proviral DNA Genotyping.

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DNA Drugs RNA Genotype 98

The Pharma Data

OCTOBER 9, 2021

Food and Drug Administration (FDA) Antimicrobial Drugs Advisory Committee (AMDAC) voted unanimously to recommend use of maribavir (TAK-620) for the treatment of refractory cytomegalovirus (CMV) infection and disease with genotypic resistance to ganciclovir, valganciclovir, foscarnet or cidofovir in transplant recipients. About maribavir.

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Drugs Genotype Bioavailability Medicine 52

The Pharma Data

MARCH 7, 2022

The IGA results in the equivalent genotype (genetic make-up) and short-hair coat trait seen in some conventionally bred cattle, known as a “slick” coat. This is the FDA’s first low-risk determination for enforcement discretion for an IGA in an animal for food use. “It The low-risk determination was provided to Acceligen.

Genome 52

Genome Genomics Production Marketing 52

pharmaphorum

AUGUST 11, 2022

First, members who opt-in to the program receive a saliva collection kit, which is analysed using newly developed pharmacogenomics technologies. With this promise beginning to be realised, it’s on drug makers to use genomic testing to steer their development process.

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Genome Genomics Genetics Drugs 97

XTalks

APRIL 15, 2021

Experts from Servier and Genuity Science recently spoke on a webinar about using genomics data to drive drug development in heart failure and identify new targets for novel therapeutics. The reverse could also be true whereby the development of coronary artery disease may impact heart rate. HFrEF vs. HFpEF.

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Development Drugs Genome Genomics 98

pharmaphorum

NOVEMBER 10, 2021

This database should support automatic importation from hospitals, laboratories and surveillance networks and link to genotypic data when available.”. New agents: Development and accessibility. This information would support the design and implementation of stewardship programmes.”.

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Medicine Genome Genomics Genotype 104

XTalks

JANUARY 22, 2021

Taiwan-based health and biotech company MedFluid has developed a rapid automated bacterial identification screening tool that can also tailor antibiotic treatments to an infection. It identifies bacteria using both genotypic and phenotypic assessments within 1.5

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Bacteria In-Vitro Genotype Marketing 52

XTalks

SEPTEMBER 28, 2020

The test was developed by Resolution Bioscience and the company will run test analyses in its labs. The Resolution ctDx Lung assay was developed to offer patients and clinicians with pertinent information that can inform treatment decisions. Related: Liquid Biopsies Help Match Cancer Patients to Phase I Trials.

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Gene DNA Life Science Genotype 105

XTalks

MARCH 3, 2021

BridgeBio is dedicated to developing therapies for genetic diseases with unmet needs. BridgeBio said in an announcement that the novel therapy was developed based on “BridgeBio’s commitment to developing a treatment for MoCD Type A in collaboration with the experts and families in the MoCD Type A community.”

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FDA Approval Genotype Clinical Trials Clinical Trials 64

The Pharma Data

MARCH 16, 2022

It’s critical to quickly and accurately identify variants to inform ongoing research – including the ongoing development of therapeutics and vaccines. To support customers performing human genotyping, TIB Molbiol provides custom-made LightSNiP assays for SNP analysis. 2, as well as other mutations, present in the novel B.1.1.529

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In-Vitro Genotype Reagent Protein 52

The Pharma Data

DECEMBER 9, 2020

Liebisch , Vigil Neuroscience is developing a pipeline of precision-based therapies to combat both rare and common neurodegenerative diseases by restoring the vigilance of microglia. It will if the following five companies, which all launched this year with Series A financing, have anything to say about it. . Vigil Neuroscience.

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Marketing In-Vivo Protein In-Vitro 52