Sun.Jul 23, 2023

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Companies to Watch: 12 Late-Stage Contenders in Neurodegenerative Disease

BioSpace

BioSpace rounded up companies with products for Alzheimer’s, ALS, Parkinson’s and Huntington’s in the final stages of clinical testing.

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Prioritizing Relationships in Medicine

JAMA Internal Medicine

This essay discusses how the deep work of doctoring leveraged with technology can bring us close to the quadruple aim of better care, better health, lower cost, and fulfilling work.

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Roche, Alnylam Ink Potential $2.8B RNAi Partnership for Hypertension

BioSpace

With an upfront payment of $310 million in cash, Roche is partnering with Alnylam to develop the latter’s RNA interference candidate zilebesiran for hypertension patients with high cardiovascular risk.

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Gilead drops magrolimab for myelodysplastic syndromes

pharmaphorum

Gilead drops magrolimab for myelodysplastic syndromes Phil.

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European Clinical Supply Planning: Balancing Cost, Flexibility and Time

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Bavarian Nordic Drops Out of RSV Vaccine Race with Phase III Flop

BioSpace

The Danish vaccine maker’s respiratory syncytial virus candidate did not meet all primary endpoints in a late-stage study in older adults and the company is discontinuing the program.

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Teva’s smart inhaler launches in first European market

pharmaphorum

Teva’s smart inhaler launches in first European market Phil.

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New patent expiration for Sun Pharm drug WINLEVI

Drug Patent Watch

Annual Drug Patent Expirations for WINLEVI Winlevi is a drug marketed by Sun Pharm and is included in one NDA. It is available from one supplier. There are eight patents… The post New patent expiration for Sun Pharm drug WINLEVI appeared first on DrugPatentWatch - Make Better Decisions.

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Gilead Drops Late-Stage Trial for Magrolimab in Blood Cancer Treatment

BioSpace

Despite the lifting of the FDA’s partial clinical hold, Gilead will discontinue magrolimab’s development in higher-risk myelodysplastic syndromes after a Phase III study met the bar for futility.

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Switch study says patients prefer ViiV’s injectable HIV drug

pharmaphorum

Switch study says patients prefer ViiV’s injectable HIV drug Phil.

Drugs 87
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Exploring the Impact of Natural Disasters After Pfizer Plant Damaged

BioSpace

It’s still unclear if the tornado damage to Pfizer’s Rocky Mount, NC, manufacturing plant will affect supply chains, but it wouldn’t be unprecedented.

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Silicosis Among Immigrant Engineered Stone (Quartz) Countertop Fabrication Workers in California

JAMA Internal Medicine

This case series describes clinical, socioeconomic, and occupational characteristics of patients diagnosed with silicosis associated with occupational exposure to engineered stone in California.

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FDA Greenlights 35 Novel Approvals in H1, Biologics Stand Out

BioSpace

The FDA’s CBER approved nine novel therapies in the first half of 2023, with several more high-profile decisions on deck for the second half of the year.

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A Work by Rodin With a Message for Clinicians

JAMA Internal Medicine

This essay describes the author’s experience of viewing The Thinker in Paris and being reminded that clinicians too need to stop and think.

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Kodiak Sciences Scraps Late-Stage Vision Loss Biologic

BioSpace

Company shares fell over 50% after two late-stage studies failed to demonstrate vision improvements in patients with diabetes macular edema.

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Which pharmaceutical companies have the largest patent portfolios?

Drug Patent Watch

A strong patent portfolio is at the core of branded pharmaceutical firms. Accordingly, one way to assess the relative strength of pharmaceutical firms is to compare their patent-counts. This chart… The post Which pharmaceutical companies have the largest patent portfolios? appeared first on DrugPatentWatch - Make Better Decisions.

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Pfizer, Gilead, GSK to Capture Growing Infectious Diseases Market as J&J Pulls Back

BioSpace

The infectious diseases market is expected to reach $150 billion in sales by 2029, with three pharma giants reaping most of its benefits, according to data analytics and consultancy GlobalData.

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Excess Death Rates for Republican and Democratic Voters in Florida and Ohio During the COVID-19 Pandemic

JAMA Internal Medicine

This cross-sectional study examines the differences in excess death rates between Republican and Democratic voters in Florida and Ohio after the COVID-19 vaccine became available for all adults.