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Epigenetic Editing with CRISPR Might Be Easier Than We Thought

XTalks

These modifications regulate gene expression without changing the sequence or structure of DNA. The epigenome plays a key role in many diseases such as heart disease, viral infections and cancer, and the new CRISPRoff technology could lead to powerful epigenetic therapies. It’s a great tool for controlling gene expression.”.

DNA 98
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Using CRISPR to Edit the Epigenome Might Be Easier Than We Thought

XTalks

These modifications regulate gene expression without altering the sequence or structure of DNA. The epigenome plays a key role in many diseases such as heart disease, viral infections and cancer, and the new CRISPRoff technology could lead to powerful epigenetic therapies. It’s a great tool for controlling gene expression.”.

DNA 52
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The use of base editing in stem-cell based therapies

Drug Discovery World

Adult fibroblasts were cultured in a cocktail of transcription factors to reactivate embryonic gene expression patterns 2. For editing of stem cells, this raises the possibility of designing iPSC-derived cell therapies where gene regulatory networks can be altered through the silencing or activation of specific genes and pathways.