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Ginkgo Bioworks awarded DARPA contract for therapeutic proteins 

Drug Discovery World

The Defense Advanced Research Projects Agency (DARPA) has announced that Ginkgo Bioworks, which is building a platform for cell programming and biosecurity, has been awarded a four-year contract worth up to $18 million to reimagine how to manufacture complex therapeutic proteins.

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Sensyne, Oxford University deploy AI to find asthma targets

pharmaphorum

The three-year project – led by respiratory medicine expert Dr Timothy Hinks from the Oxford University Respiratory Medicine Unit – will use whole-genome sequencing of around 500 patients with severe asthma, comparing their gene sequences with control subjects who don’t have asthma.

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Vertex eyes controllable genetic drugs with $1.3bn Obsidian alliance

pharmaphorum

The alliance is based on Obsidian’s cytoDRIVE platform, which uses already approved small-molecule drugs alongside gene-editing medicines to control the expression of protein from a gene sequence. For example, adding a small-molecule might stabilise the medicine, allowing levels of the target protein to increase.

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Medicago, GSK’s plant-made COVID jab clears phase 2

pharmaphorum

The vaccine takes the form of SARS-CoV-2 spike protein expressed in virus-like-particles (VLPs), produced in plants that function as mini bioreactors. The purified vaccine is administered alongside GSK’s pandemic adjuvant to boost the immune response.

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A different approach: reimagining biology

Drug Discovery World

Evonetix believes this will break dependence on the service provider approach giving users the power to prepare gene sequences rapidly in their own laboratories. from 2002 as a Protein Engineer and major contributor to its disruptive NGS technology. Why enzymatic synthesis?

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Rising Demand for DNA and Gene Cloning  Service Providers

Roots Analysis

Once isolated, molecular clones can be used to generate multiple copies of DNA for the analysis of gene sequences and / or to express proteins obtained for the study or utilization of protein function. These clones can be manipulated and mutated in vitro to alter the expression and function of a protein.

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