Drug Discovery World

FEBRUARY 27, 2024

Reece A: What are some of the human limitations to current drug discovery research for immunotherapies? While we have made a lot of progress in targeted therapeutics by identifying molecular tumour drivers that define patient subsets, genomics has not quite produced the same level of understanding for tumour-immune biology.

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Drug Discovery World

APRIL 4, 2024

The university will also support the European Union’s 1+ Million Genomes initiative, which seeks to boost innovation in healthcare across Europe. Driving new understanding 10,000 whole human genomes will be sequenced and analysed by the Institute of Genomics at the University of Tartu.

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Biobanking Genome Genomics Genome Project 52

Advarra

FEBRUARY 28, 2023

In an effort to accelerate the sharing of biomedical research results, the National Institutes of Health (NIH) issued its finalized Data Management and Sharing (DMS) policy , effective January 25, 2023. The policy statement supported reusing existing scientific data and accessibility of high value datasets for use in future research studies.

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Research Genome Genomics Genotype 52

Drug Discovery World

NOVEMBER 23, 2023

Research that once took months to complete – requiring synthesizing and testing compounds – can now be done in days and even hours using AI. In anticipation of the long-awaited personalised medicine revolution, many different types of biobanks have emerged to catalogue samples. But the utility of biobanks varies.

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Biobanking Drugs Medicine Genome 59

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Generation of strong research dataset cohorts must begin with high-quality clinical samples. Partnerships and Establishing Research Cohorts.

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Research Biobanking Drugs Genome 98

pharmaphorum

NOVEMBER 10, 2021

“Better estimates of the burden of antimicrobial resistance in humans and animals depend on better microbiological data and more clarity on the appropriate design of epidemiological research. This database should support automatic importation from hospitals, laboratories and surveillance networks and link to genotypic data when available.”.

Medicine 104

Medicine Genome Genomics Genotype 104

Delveinsight

DECEMBER 13, 2020

Research and development in Hepatitis. However, there is still a need for further research on HCV and the risk factors that lead to the progression of fibrosis, cirrhosis, and Hepatocellular carcinoma (HCC). Typically, pan-genotypic treatments have high cure rates, few side effects, and short treatment durations (usually 8–12 weeks).

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Genotype FDA Approval DNA Drugs 52

Drug Discovery World

JULY 15, 2022

The first complete, gapless sequence of a human genome was published 1 April 2022 in a special issue of the journal Science 1. While The Human Genome Project mapped about 92% of the human genome two decades ago, sequencing the last 8% of the genome proved highly challenging.

Genome 52

Genome Genomics DNA Containment 52

XTalks

APRIL 29, 2021

However, the variant viral genomes will still persist in the latent reservoir as provirus and can be detected with proviral DNA testing. Importantly, ARV treatment does not affect the proviral DNA genome that persists in latently infected cells. Proviral DNA Genotyping. GenoSure Archive.

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DNA Drugs RNA Genotype 98

XTalks

APRIL 15, 2021

New advances in heart failure genomics are helping to address this challenge. Experts from Servier and Genuity Science recently spoke on a webinar about using genomics data to drive drug development in heart failure and identify new targets for novel therapeutics. Watch this on-demand webinar to hear from these experts.

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Development Drugs Genome Genomics 98

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. Nutrigenomics is the science studying the relationship between human genome, nutrition and health.

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Genome Genomics Genetics Gene 40

Drug Discovery World

OCTOBER 30, 2023

RA: You’ve recently announced a collaboration with the University of Oxford to access genotype data on women with endometriosis. We previously conducted a hypothesis-free study using genotype data from the UK Biobank, which resulted in the first mechanism-based stratification of endometriosis patients.

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Genome Genomics Genotype Clinical Trials 72

Drug Discovery World

MAY 2, 2023

Some of the most important breakthroughs in pharmaceutical research were adapted from naturally occurring phenomena. In an effort to defend themselves against viral infection, bacterial cells capture and copy DNA fragments of bacteriophages into their genome. The gRNA is accompanied by the Cas9 enzyme responsible for cutting DNA.

Genome 52

Genome Genomics Gene DNA 52

XTalks

APRIL 24, 2023

“Rare disease clinical trials are complex due to the additional scientific, medical, operational and regulatory requirements of newly emerging advanced therapies, such as gene therapy,” says Dr. Terence Eagleton, MB BS, Senior Medical Director at the global clinical research organization (CRO) Medpace.

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Gene Therapy Gene Trials Clinical Trials 95

Worldwide Clinical Trials

DECEMBER 12, 2022

genotyping for known variants vs sequencing only vs sequencing and concurrent deletion/duplication analysis), and whether the interpretation of the genetic testing results may have changed over time. What is the difference between a Clinical Laboratory Improvement Amendments (CLIA)-approved laboratory vs a research laboratory?

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Clinical Trials Clinical Trials Genetics Trials 130

Drug Discovery World

MARCH 1, 2023

Avtar Singh is a Senior Scientist in the Cell and Tissue Genomics Department at Genentech, where he develops new approaches for image-based screening and high-throughput biological discovery. MT: What impact have pooled CRISPR screens had on our ability to perform analyses at genome scale?

Genetics 52

Genetics Genome Genomics Genotype 52

The Pharma Data

SEPTEMBER 2, 2021

Durvalumab ± Tremelimumab + Platinum-Etoposide in 1L ES-SCLC: Exploratory Analysis of HLA Genotype and Survival in CASPIAN. A Phase 2 Study of Datopotamab Deruxtecan (Dato-DXd) in Advanced NSCLC With Actionable Genomic Alterations (TROPION-Lung05). Lead author. Abstract title. Presentation details. Immuno-Oncology. Garassino, MC.

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Trials Medicine Antibody Clinical Trials 52

pharmaphorum

FEBRUARY 17, 2022

Researchers discovered a highly virulent variant of HIV in the Netherlands that genetic sequence analysis suggests has been circulating since the 1990s. . Led by researchers from the University of Oxford ‘s Big Data Institute, the study underscores the significance of analysing viruses continually over time. The VB variant.

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Genome Genomics Genetics Genotype 98