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Biopharma Update on the Novel Coronavirus: October 20

The Pharma Data

DB ( Becton, Dickinson and Company ) received a CE mark for its BD Multitest 6-Color TBNK Reagent with BD Trucount Tubes for assessing immune function in COVID-19 patients. It allows the test to be used for people without any symptoms or suspicion of COVID-19, supporting widespread population testing. Please read more here. .

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CRISPR breakthroughs: New solutions for common diseases

Drug Discovery World

Current research is focused on designing CRISPR-enhanced CAR T cells that are resistant to immunosuppressive cytokines such as transforming growth factor-β (TGF-β) 2 , programmed cell death protein (PD-1) 3 , or other negative T cell regulators 4 (CTLA-4, LAG-3, and TIM-3), thus improving anti-tumour functions.

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Overcoming inefficiencies to improve access to cell and gene therapy 

Drug Discovery World

Before 2019, CGT drug developers still had a young, academic mindset, ordering reagents, materials, and equipment haphazardly and assuming they would show up when needed. Jude Children’s Research Hospital where she researched mechanisms of immune regulation. Prior to joining KBI, she was Director of Immunology at Opexa Therapeutics.

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Delivering on the promise of gene editing

Drug Discovery World

Potential solutions: For CRISPR systems, the likelihood of off-target editing has been shown to be influenced by a variety of factors, ranging from the design of the gRNA 1 and Cas9 protein 2 , to the targeted cell type 3 , to name a few examples. Topping the list of alternatives are lipid nanoparticles (LNPs) and electroporation.