Clinical Research Informer

Grand Rounds December 15, 2023: Diversifying Clinical Trials: A Path Forward (Roxana Mehran, MD, FACC, FAHA, MSCAI, FESC)

Rethinking Clinical Trials

DECEMBER 20, 2023

Globally cardiovascular disease (CVD) prevalence had decreased between 1990 and 2010, but it has slightly increased since 2010. Further efforts are urgently needed to increase diversity in the cardiology workforce, which will improve clinical trial diversity and cardiovascular health for all. years for males and 5.5

Clinical Trials

Clinical Trials Clinical Trials Trials Cardiology

Grand Rounds November 17, 2023: Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study (Michael Ho, MD, PhD; Sheana Bull, PhD)

Rethinking Clinical Trials

NOVEMBER 21, 2023

In Years 2-5 (UH3 Phase) the aims were to conduct and evaluate a pragmatic patient-level randomized intervention across 3 healthcare systems to improve adherence to chronic cardiovascular (CV) medications. Patients could reply with Done and the message reminders would stop. The study would then recalculate the gaps.

Clinical Trials

Clinical Trials Clinical Trials Trials Development

Grand Rounds January 20, 2023: Collaborative Pragmatic Trials in Action: EVOLVE-MI (Mikhail Kosiborod, MD)

Rethinking Clinical Trials

JANUARY 26, 2023

There is little question about the utility of LDL lowering as a means of cardiovascular risk reduction. The treatment is on-label because anyone with an acute coronary has at risk cardiovascular disease so technically it is on-label. This study is looking at a particular subpopulation, where there is a lack of outcomes data.

Trials

Trials Clinical Trials Clinical Trials Medicine

Grand Rounds July 14, 2023: Lessons From the COORDINATE-Diabetes Trial (Christopher B. Granger, MD; Neha J. Pagidipati, MD, MPH)

Rethinking Clinical Trials

JULY 19, 2023

These therapies included an anti-hyperglycemic agent with evidence for cardiovascular benefit, ACEi/ARB/ARNI, and high-intensity statin. Tags #pctGR, @Collaboratory1 The post Grand Rounds July 14, 2023: Lessons From the COORDINATE-Diabetes Trial (Christopher B. However, these therapies are highly underused in routine clinical practice.

Trials

Trials Cardiology Medicine Nurses

Grand Rounds February 9, 2024: Pragmatic Recruitment of Underrepresented Groups – Experience From the Diuretic Comparison Project (Cynthia Hau, MPH)

Rethinking Clinical Trials

FEBRUARY 14, 2024

DCP started to understand if chlorthalidone would be more effective at preventing cardiovascular (CV) outcomes compared to hydrochlorothiazide for thiazide-type diuretic. Both drugs have a well-established safety profile and would be a good fit for a pragmatic design.

Clinical Trials

Clinical Trials Clinical Trials Cardiology Trials

Grand Rounds April 21, 2023: Personalised Cooler Dialysate for Patients Receiving Maintenance Haemodialysis (MyTEMP): A Pragmatic, Cluster-randomised Trial (Amit Garg, MD, MA, FRCPC, FACP, PhD; Stephanie N. Dixon, PhD MSc)

Rethinking Clinical Trials

APRIL 27, 2023

The primary composite outcome was cardiovascular mortality or hospital admission with MI, stroke, or heart failure. The lack of cardiovascular benefit and higher likelihood of patient discomfort provides no justification to adopt cooler dialysate as a center-wide policy vs. use of 36.5

Trials

Trials Clinical Trials Clinical Trials Medicine

American health is in for a “world of hurt”

World of DTC Marketing

NOVEMBER 3, 2020

Cardiovascular disease deaths in the US have increased by nearly 17% since 2010, and are among the reasons that life expectancy in the U.S. is lower than in other high-income countries. has also seen reversals in health improvements since 2010, partly due to increasing rates of obesity, high blood pressure, and high blood sugar. .

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Pharma Companies Scientist Medicine Research

Grand Rounds Ethics and Regulatory Series February 10, 2023: Informing and Consenting: What Are the Goals? (P. Pearl O’Rourke, MD; David S. Wendler, PhD, MA; Miguel Vazquez, MD; P. Michael Ho, MD, PhD)

Rethinking Clinical Trials

FEBRUARY 16, 2023

The Nudge Study is a pragmatic clinical trial seeking to improve medication adherence to patients’ already-prescribed cardiovascular medications through a series of theory-based text or voice messages that served as “nudges.” Opt-outs were different across health systems. Pearl O’Rourke, MD; David S.

Clinical Trials

Clinical Trials Clinical Trials Medicine Trials

Grand Rounds October 6, 2023: Hybrid Studies Should Not Sacrifice Rigorous Methods (David M. Murray, PhD; Moderator: Jonathan Moyer, PhD)

Rethinking Clinical Trials

OCTOBER 11, 2023

Through this initiative, 7 Clinical Centers are expected to test an evidence-based, multi-level intervention designed to reduce or eliminate cardiovascular and/or pulmonary health disparities. Tags #pctGR, @Collaboratory1 The post Grand Rounds October 6, 2023: Hybrid Studies Should Not Sacrifice Rigorous Methods (David M.

Clinical Trials

Clinical Trials Clinical Trials Trials Research

Grand Rounds December 2, 2022: A Randomized Controlled Trial of Mobile Health Intervention in Heart Failure and Diabetes: Lessons Learned (G. Michael Felker, MD, MHS)

Rethinking Clinical Trials

DECEMBER 6, 2022

Director, Cardiovascular and Metabolism Research, DCRI. . Speakers. Michael Felker, MD, MHS. Professor of Medicine. Pragmatic Clinical Trials, Heart Failure, Diabetes. Key Points. Sites have a lot of trials that are competing. One pays more than another.

Trials

Trials Clinical Trials Clinical Trials Compliance

Grand Rounds September 16, 2022: Using Nationwide Registries to Conduct Pragmatic Randomized Trials: The DANFLU Program (Tor Biering-Sørensen, MD, PhD, MPH)

Rethinking Clinical Trials

SEPTEMBER 22, 2022

Head of Cardiovascular Non-Invasive Imaging Research Laboratory. Head of Center for Translational Cardiology and Pragmatic Randomized Trials. Department of Biomedical Sciences. Faculty of Health and Medical Sciences. University of Copenhagen. Department of Cardiology. Copenhagen University Hospital – Herlev and Gentofte. Learn more.

Trials

Trials Cardiology Vaccination Vaccine

Gene Silencing Porphyria Treatment, Givlaari, Finally Wins Over England’s NICE Amid Stellar Long-Term Data

XTalks

OCTOBER 26, 2021

The treatment came with an initial price tag of $39,000 per vial, which amounts to a total of $575,00 each year. Experts say gene silencing through RNA interference holds great promise in the targeting of diseases ranging from cancer to Alzheimer’s and cardiovascular disease.

Gene Silencing

Gene Silencing Gene Clinical Trials Clinical Trials

Perfusion MRI and Other Perfusion Imaging Techniques for Clinical Trials

XTalks

OCTOBER 12, 2022

For ASL MR perfusion, water molecules in arterial blood from a feeder artery are magnetically tagged and tracked until they reach the region of interest. Then, the signal difference in the region of interest between the tagged images and control images can be computed to obtain cerebral blood flow (CBF) values ( Figure 3 ).

Clinical Trials

Clinical Trials Clinical Trials Trials Drugs

Grand Rounds January 19, 2024: Why Are Imaging RCTs Different? Lessons From Chest Pain Evaluation Trials (Pamela S. Douglas, MD, MACC, FASE, FAHA)

Rethinking Clinical Trials

JANUARY 23, 2024

Tags #pctGR, @Collaboratory1 The post Grand Rounds January 19, 2024: Why Are Imaging RCTs Different? The tests are so common in aggregate it is a big expense. – What is the sensitivity of portable AI ECHO devices? They are pretty good. We think about it as a screening tool to see if a patient needs an intervention.

Trials

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Grand Rounds April 7, 2023: A Nudge Towards Cardiovascular Health: Incorporating Insights From Behavioral Science to Improve Cardiovascular Care Delivery (Srinath Adusumalli, MD, MSHP, MBMI, FACC)

Rethinking Clinical Trials

APRIL 13, 2023

Tags #pctGR, @Collaboratory1 The post Grand Rounds April 7, 2023: A Nudge Towards Cardiovascular Health: Incorporating Insights From Behavioral Science to Improve Cardiovascular Care Delivery (Srinath Adusumalli, MD, MSHP, MBMI, FACC) appeared first on Rethinking Clinical Trials.

Medicine

Medicine Trials Cardiology Development

Grand Rounds January 27, 2023: The PREPARE II Trial: Embedding a Pragmatic Trial Into Clinical Care During an Emergency Procedure (Derek W. Russell, MD; Matthew W. Semler, MD, MSc)

Rethinking Clinical Trials

FEBRUARY 2, 2023

The outcome was no benefit from fluid bolus before induction at prevention of cardiovascular collapse. The occurrence of cardiovascular collapse was 18.2% Learn more Read more in JAMA: Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation.

Trials

Trials Clinical Trials Clinical Trials Medicine

Ways IoT Has Transformed The Pulse Of Healthcare, And Will Continue To Do So In The Future

Delveinsight

JULY 22, 2020

This helps in analysis and diagnosis of health conditions like cardiovascular disease. The hospital inventory is equipped with tagged sensors. The sedentary lifestyle over the past few years has given rise to many chronic diseases such as blood pressure, cardiovascular diseases, depression , diabetes , obesity and anxiety.

Doctors

Doctors Doctor Marketing Production

Grand Rounds February 17, 2023: The Heartline Trial: A New Paradigm in Conducting Virtual Clinical Trials (C. Michael Gibson, MS, MD)

Rethinking Clinical Trials

FEBRUARY 22, 2023

The question is can we pivot from very expensive trials to test cardiovascular drugs to at least a hybrid model that takes the best of what we have learned so far from the Heartline Trial? Tags #pctGR, @Collaboratory1 The post Grand Rounds February 17, 2023: The Heartline Trial: A New Paradigm in Conducting Virtual Clinical Trials (C.

Clinical Trials

Clinical Trials Clinical Trials Trials Nurses

A history of Johnson & Johnson

pharmaphorum

FEBRUARY 26, 2021

Cordis was founded in Miami in 1959 and develops and produces medical equipment to treat patients who suffer from cardiovascular disease. For all the latest pharma news on Johnson & Johnson, follow pharmaphorum’s J&J and Janssen tags. CEO Alex Gorsky, who was appointed in 2012.

Sales

Sales Production Pharma Companies Marketing

Grand Rounds November 4, 2022: The CardioNerds Clinical Trials Network: Pairing Equitable Enrollment with Trainee Development (Amit Goyal, MD, MAS)

Rethinking Clinical Trials

NOVEMBER 9, 2022

The mission is to democratize cardiovascular education by creating and disseminating education, fostering wellness and humanism, promoting diversity, equity and inclusion, providing mentorship and sponsorship, and invigorating a love of cardiovascular science. Learn more. Visit the CardioNerds website. Discussion Themes.

Clinical Trials

Clinical Trials Clinical Trials Trials Development

Grand Rounds October 27, 2023: Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial (Harlan M. Krumholz, MD, SM)

Rethinking Clinical Trials

OCTOBER 31, 2023

Tags #pctGR, @Collaboratory1 The post Grand Rounds October 27, 2023: Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial (Harlan M. Speaker Harlan M. Krumholz, MD, SM Harold H. One of the main reasons we turn people away is because they are taking a medication that does not work with Paxlovid.

Trials

Trials Medicine Research Clinical Trials

Clinical Research Informer

Grand Rounds December 15, 2023: Diversifying Clinical Trials: A Path Forward (Roxana Mehran, MD, FACC, FAHA, MSCAI, FESC)

Grand Rounds November 17, 2023: Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study (Michael Ho, MD, PhD; Sheana Bull, PhD)

Trending Sources

Grand Rounds January 20, 2023: Collaborative Pragmatic Trials in Action: EVOLVE-MI (Mikhail Kosiborod, MD)

Grand Rounds July 14, 2023: Lessons From the COORDINATE-Diabetes Trial (Christopher B. Granger, MD; Neha J. Pagidipati, MD, MPH)

Grand Rounds February 9, 2024: Pragmatic Recruitment of Underrepresented Groups – Experience From the Diuretic Comparison Project (Cynthia Hau, MPH)

Grand Rounds April 21, 2023: Personalised Cooler Dialysate for Patients Receiving Maintenance Haemodialysis (MyTEMP): A Pragmatic, Cluster-randomised Trial (Amit Garg, MD, MA, FRCPC, FACP, PhD; Stephanie N. Dixon, PhD MSc)

American health is in for a “world of hurt”

Grand Rounds Ethics and Regulatory Series February 10, 2023: Informing and Consenting: What Are the Goals? (P. Pearl O’Rourke, MD; David S. Wendler, PhD, MA; Miguel Vazquez, MD; P. Michael Ho, MD, PhD)

Grand Rounds October 6, 2023: Hybrid Studies Should Not Sacrifice Rigorous Methods (David M. Murray, PhD; Moderator: Jonathan Moyer, PhD)

Grand Rounds December 2, 2022: A Randomized Controlled Trial of Mobile Health Intervention in Heart Failure and Diabetes: Lessons Learned (G. Michael Felker, MD, MHS)

Grand Rounds September 16, 2022: Using Nationwide Registries to Conduct Pragmatic Randomized Trials: The DANFLU Program (Tor Biering-Sørensen, MD, PhD, MPH)

Gene Silencing Porphyria Treatment, Givlaari, Finally Wins Over England’s NICE Amid Stellar Long-Term Data

Perfusion MRI and Other Perfusion Imaging Techniques for Clinical Trials

Grand Rounds January 19, 2024: Why Are Imaging RCTs Different? Lessons From Chest Pain Evaluation Trials (Pamela S. Douglas, MD, MACC, FASE, FAHA)

Grand Rounds April 7, 2023: A Nudge Towards Cardiovascular Health: Incorporating Insights From Behavioral Science to Improve Cardiovascular Care Delivery (Srinath Adusumalli, MD, MSHP, MBMI, FACC)

Grand Rounds January 27, 2023: The PREPARE II Trial: Embedding a Pragmatic Trial Into Clinical Care During an Emergency Procedure (Derek W. Russell, MD; Matthew W. Semler, MD, MSc)

Ways IoT Has Transformed The Pulse Of Healthcare, And Will Continue To Do So In The Future

Grand Rounds February 17, 2023: The Heartline Trial: A New Paradigm in Conducting Virtual Clinical Trials (C. Michael Gibson, MS, MD)

A history of Johnson & Johnson

Grand Rounds November 4, 2022: The CardioNerds Clinical Trials Network: Pairing Equitable Enrollment with Trainee Development (Amit Goyal, MD, MAS)

Grand Rounds October 27, 2023: Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial (Harlan M. Krumholz, MD, SM)

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