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FDA gives AbbVie’s c-Met lung cancer ADC a breakthrough tag

pharmaphorum

Teliso-V is currently in a 233-patient phase 2 study (LUMINOSITY) involving subjects with c-Met-positive, non-squamous NSCLC as a second- or third-line treatment after chemotherapy, immunotherapy with checkpoint inhibitors or drugs targeted at specific mutations. Preliminary results from that study showed a 53.8%

Antibody 109
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Cancer research drugs: Where is the innovation?

Drug Discovery World

Click’ chemistry used to tag proteins made by cancer cells. Targeted colon cancer treatment overcomes chemotherapy resistance. A team from the University of Geneva (UNIGE) has found a way to overcome chemotherapy resistance in colorectal cancer. Merck and Moderna to develop personalised cancer vaccine.

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Blue Note leukaemia DTx gets FDA breakthrough tag

pharmaphorum

The DTx, called BNT200, is described as a first-of-its-kind DTx to treat anxiety and depression in adults with acute myeloid leukaemia (AML) who are hospitalised for a regimen of high-intensity induction chemotherapy. The DTx is an on-demand stress management intervention with content synchronised with high-intensity chemotherapy treatment.

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Gilead tags Merck for first-line triple negative breast cancer trial

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Trodelvy has already established itself as a go-to therapy for TNBC patients whose disease has progressed after prior treatments, says Gilead, while Keytruda is approved as a first-line therapy for the cancer in combination with chemotherapy, in patients with PD-L1 scores of 10 or more. While its headline revenue of $7.4

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FDA gives Daiichi Sankyo’s HER3 drug a breakthrough tag

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Patritumab deruxtecan achieved an overall response rate of 25% when given as a therapy to patients with EGFR-mutated NSCLC whose cancer had progressed despite treatment with a third-generation EGFR inhibitor like AstraZeneca’s Tagrisso (osimertinib) and platinum-based chemotherapy.

Drugs 70
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Enhertu gets breakthrough tag in HER2-low breast cancer

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The coveted status has been awarded to the HER2-targeting antibody-drug conjugate (ADC) on the back of the DESTINY-Breast04 trial results, unveiled in February, which involved patients with HER2-low, unresectable and/or metastatic breast cancer previously treated with one to two prior lines of chemotherapy.

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Immunocore gets EU nod for TCR cancer therapy Kimmtrak

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The one-year survival rate with the drug was 73%, compared to 58% in a group receiving standard-of-care – off-label immune checkpoint inhibitors used for other forms of melanoma like Merck & Co’s Keytruda (pembrolizumab) and Bristol-Myers Squibb’s Yervoy (ipilimumab) or chemotherapy with dacarbazine.

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