Scienmag

JULY 15, 2021

A new protein-based vaccine candidate combined with a potent adjuvant provided effective protection against SARS-CoV-2 when tested in animals, suggesting that the combination could add one more promising COVID-19 vaccine to the list of candidates for human use.

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Scienmag

OCTOBER 6, 2020

— Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system. HERSHEY, Pa.

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Scienmag

OCTOBER 14, 2020

Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction, supports a mechanism critical for survival in mouse models of sepsis and colitis Credit: UC San Diego Health Sciences The immune response to infections is a delicate balance.

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Protein Immune Response Bacteria Allergies 67

Scienmag

JUNE 30, 2021

A 7- to 15-year longitudinal study of 358 diabetics has linked 3 proteins in blood with a slower progression of diabetic kidney disease and progressive kidney failure.

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Protein Research Allergies Medicine 40

Scienmag

APRIL 22, 2021

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Researchers have identified another potential target for neutralizing antibodies on the SARS-CoV-2 Spike protein that is masked by metabolites in the blood.

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Pharmaceutical Technology

FEBRUARY 3, 2023

The Janssen vaccines studied in the Imbokodo and Mosaico studies were based on the mosaic concept, where they were intentionally designed to include a broader immunogen that could be used everywhere, says Dr. Mary Marovich, director of the Vaccine Research Program at National Institute of Allergy and Infectious Diseases (NIAID).

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Scienmag

MARCH 4, 2021

A deep sequencing study of 747 SARS-CoV-2 virus isolates has revealed mutant peptides derived from the virus that cannot effectively bind to critical proteins on the surface of infected cells and, in turn, hamper activation of CD8+ killer T cells that recognize and destroy these infected cells.

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Protein Allergies Vaccination Vaccine 54

The Pharma Data

JANUARY 11, 2021

They give the body a blueprint to create a bit of the virus that causes COVID-19, called a spike protein. Once you are vaccinated, the cell’s machinery uses the blueprint to make the spike protein. This protein then appears on the surface of the cell and the immune system responds to it.

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Scienmag

OCTOBER 14, 2020

Animal study shows treatment blocks inflammation and protects lungs without killing the flu virus COLUMBUS, Ohio – The raging lung inflammation that can contribute to death from the flu can be stopped in its tracks by a drug derived from a naturally occurring human protein, a new animal study suggests.

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Protein Drugs Allergies Medicine 40

Scienmag

JULY 23, 2021

Antibodies capable of neutralizing multiple SARS-CoV-2 strains can inform strategies for broadly protective COVID-19 booster vaccines As the SARS-CoV-2 virus that causes COVID-19 continues to evolve, immunologists and infectious diseases experts are eager to know whether new variants are resistant to the human antibodies that recognized initial versions (..)

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Drug Discovery World

JANUARY 21, 2024

It is enabling computational protein design for vaccine immunogen discovery, and high-throughput and high-definition assays for quicker and more comprehensive characterisation of vaccine candidates and vaccine-elicited immunity. His recent research focuses on vaccines against influenza and other (re)emerging viruses.

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Drug Discovery World

MARCH 23, 2023

The study was co-funded by the National Institute of Allergy and Infectious Diseases (NIAID) and led by Mark M Davis, Director of the Stanford Institute for Immunity, Transplantation and Infection and a professor of microbiology and immunology at Stanford University School of Medicine in California.

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Scienmag

JUNE 22, 2021

New research published in the Journal of Cellular and Molecular Medicine indicates that SARS-CoV-2, the virus that causes COVID-19, produces microRNAs that can have impacts on infected cells. Investigators found that the […].

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Protein Genetics Medicine Production 42

Scienmag

SEPTEMBER 28, 2020

29, 2020 – A study from the University of Pittsburgh School of Medicine and Cedars-Sinai addresses a mystery first raised in March: Why do some people with COVID-19 develop severe inflammation? The research shows how the molecular structure and sequence of the SARS-CoV-2 spike protein–part of the virus that causes […].

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Protein Medicine Development Research 64

Scienmag

JUNE 14, 2021

A new therapy prompts immune defense cells to swallow misshapen proteins, amyloid beta plaques and tau tangles, whose buildup is known to kill nearby brain cells as part of Alzheimer’s disease, a new study shows.

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Protein Medicine Research Allergies 56

The Pharma Data

MARCH 13, 2022

That’s because the mutations that led to the variant’s emergence aren’t found in the regions of the virus that stimulates one type of cellular immune response, says an international research team from Johns Hopkins Medicine, in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) and ImmunoScape, a U.S.-Singapore

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Immune Response Protein Medicine Genetics 52

Scienmag

APRIL 22, 2021

In February, the researchers introduced […].

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Production Vaccination Vaccine Protein 84

XTalks

JUNE 21, 2021

who is on a mission to help parents save their children from food allergies by providing them with a powder added to their milk bottles. Zakowski started this company because his nephew developed several severe food allergies. Related: Red Meat Allergy Test Gets FDA Clearance. The product is part of a three-step guidance system.

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pharmaphorum

DECEMBER 23, 2021

Children in England with peanut allergies could be among the first in Europe to get access to Aimmune’s oral immunotherapy Palforzia, after the drugmaker agreed a supply deal with NHS England. billion last year, is also developing immunotherapies for other indications including egg and multi-tree nut allergies.

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XTalks

SEPTEMBER 8, 2020

“Our experience in drug product fill/finish will enable timely manufacturing to make the vaccine available as soon as possible to advance bringing life-changing medicines to market.”. The genetic material contains SARS-CoV-2 spike protein. Fauci, in a statement. The Phase 3 trial is being implemented as part of Operation Warp Speed.

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Manufacturing Vaccination Vaccine Allergies 83

XTalks

SEPTEMBER 21, 2023

This groundbreaking endeavor has received support from the National Institute of Allergy and Infectious Diseases (NIAID). These T cells are engineered to recognize various HIV proteins in a unique manner compared to previous experimental HIV vaccines. mRNA, 2) BG505 MD39.3 gp151 mRNA and 3) BG505 MD39.3 gp151 CD4KO mRNA.

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Vaccination Vaccine Trials Clinical Trials 59

Scienmag

NOVEMBER 16, 2020

Cincinnati Children’s team reports controlling the BCAP protein could slow overactive immune response in IBD, rheumatoid arthritis or accelerate response against tumors Credit: Cincinnati Children’s Managing the activity of the BCAP protein could help the body repair intestinal tissue from damage caused by inflammation, according to a new (..)

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Immune Response Protein Allergies Medicine 78

Scienmag

JULY 6, 2021

Studies reveal unprecedented mechanism behind loss of antibody neutralization against this pandemic coronavirus variant of concern Credit: Young-Jun Park, UW Department of Biochemistry Three mutations in the Epsilon coronavirus spike protein dampen the neutralizing potency of antibodies induced by current vaccines or past COVID infections.

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Drug Discovery World

JANUARY 22, 2024

Simon Bushell, SVP of Molecular Discovery at Entact Bio, will present: ‘Proximity-inducing drugs: Using technological innovation to build the next generation of medicine’. The impact of this technology on the patients for which it is being implemented is multifaceted.

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Engineer Immune Response Drugs Vaccination 59

Scienmag

APRIL 9, 2021

The structural revelation could have implications as a therapeutic target in all SARS-CoV-2 variants Credit: Kelly Lab/Penn State A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.

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Scienmag

AUGUST 20, 2020

aureus) proteins protects mice against S. Credit: NIAID Immunization of mice with a new vaccine consisting of fungal particles loaded with Staphylococcus aureus (S. aureus infection, according to a study published August 20 2020 in the open-access journal PLOS Pathogens by David Underhill of Cedars-Sinai Medical Center, and colleagues.

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Vaccination Vaccine Protein Allergies 98

Scienmag

AUGUST 11, 2020

Antibody that blocks TREM2 protein frees immune cells to reject cancer Credit: William Vermi/Martina Molgora Immunotherapy has revolutionized cancer treatment by stimulating the patient’s own immune system to attack cancer cells, yielding remarkably quick and complete remission in some cases.

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Protein Antibody Drugs Allergies 95

Trialfacts

JANUARY 11, 2023

This study is exploring a medication that is nearly identical to a natural protein already produced by the body when we exercise in order to help reduce inflammation. Researchers are exploring a potential new treatment for CIPN and are looking for volunteers to participate in a multi-site research study in Australia.

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Research Clinical Research Allergies Protein 52

Scienmag

JUNE 6, 2021

New resource for neuroscience maps cell types, secreted proteins, spatial organization, and more Credit: Dani N, Herbst RH, et al. Cell April 30, 2021, DOI 10.1016/j.cell.2021.04.003. 2021.04.003.

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Protein Allergies Medicine 72

Scienmag

JUNE 25, 2021

Changes to the ‘spike’ protein explain Alpha’s faster spread, and how the Beta variant evades immune responses, suggesting the need for a booster with an updated vaccine Credit: Bing Chen, PhD, Boston Children’s Hospital New SARS-CoV-2 variants are spreading rapidly, and there are fears that current COVID-19 vaccines won’t (..)

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Scienmag

MARCH 15, 2021

The first vaccine has been administered in a comparative adjuvant trial of DNA prime/protein boost HIV vaccine regimens in Kericho, Kenya Credit: U.S. Military HIV Research Program SILVER SPRING, Md.

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Vaccination Vaccine Trials DNA 68

Delveinsight

AUGUST 27, 2020

The phase 1 study that is being run by the National Institute of Allergy and Infectious Diseases tests three dose levels of the vaccine, mRNA-1273, given in two injections a month apart in 120 adults. The BET inhibitor worked by increasing beta-3 tubulin (TUBB3), a protein found in brain metastases.

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Vaccination Vaccine Research Trials 53

Scienmag

OCTOBER 23, 2020

The technique should help in the design of vaccines against HIV, SARS-CoV-2 and other viruses that cloak their outer proteins with sugars to evade antibodies.

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Protein Antibody Scientist Vaccination 61

Scienmag

DECEMBER 17, 2020

The team discovered that removing the inflammatory signalling protein TNF in a laboratory model prevented early stage stomach cancers from progressing to a more severe […].

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Protein Regulation Research Allergies 52

Scienmag

JANUARY 28, 2021

Scientists from Hokkaido University, Japan and Universidade Federal do Rio Grande do Sul and Universidade Federal do Rio de Janeiro, Brazil, have revealed that substances in tick saliva activates immune response-suppressing proteins in cattle […].

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Immune Response Protein Scientist Allergies 52

Pharmaceutical Technology

AUGUST 5, 2022

As per the prevailing prion theory, a misfolded version of a normal cell-surface protein acts as the chief infectious agent. It is ultra-rare,” says Jesús Rodriguez Requena, PhD, associate professor in the Department of Medicine at the University of Santiago de Compostela. And then comes the question of the right target.

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Scienmag

OCTOBER 13, 2020

Credit: Kim Ratliff, Production Coordinator, Augusta University Dr. Guangyu Wu is dissecting the molecular homing that enables a nascent protein to ultimately find its way to the surface of a cell as a mature receptor type that helps us taste, smell and even regulate our mood and immunity.

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Protein Regulation Production Allergies 52