STAT News

FEBRUARY 16, 2023

The treatment, teplizumab, is a type of antibody therapy that blocks T cells, the “attack dogs” of the immune system, from destroying insulin-producing islet cells in the pancreas. Approved last November in the United States, it’s also the first drug proven to delay the onset of an autoimmune disorder.

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Pharmaceutical Technology

JULY 5, 2022

Through the Impact brand, which comprises insulin, glibenclamide and oxaliplatin among others, the company will supply its 30 medicines in 40 lower-income countries in the world. The post Sanofi unveils global health brand for medicines supply appeared first on Pharmaceutical Technology.

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Pharma Packaging Solutions

JUNE 30, 2023

Whole blood, organ and tissue transplants, breast milk, antibodies for passive immunity, fecal microbiota, human reproductive cells, and stem-cell therapy are all examples of this type of biologic.

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pharmaphorum

JULY 7, 2021

The complete response letter (CRL) for teplizumab as a treatment to delay clinical type 1 diabetes in at-risk individuals reiterates the FDA’s concerns around the pharmacokinetics (PK) data for the antibody.

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pharmaphorum

NOVEMBER 18, 2022

The US regulator has approved the anti-CD3 antibody as Tzield to delay the onset of stage 3 T1D in people eight years and older who currently have stage 2 disease, which according to the FDA “may provide patients with months to years without the burdens of disease.”

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STAT News

NOVEMBER 18, 2022

The monoclonal antibody teplizumab, which will be marketed under the brand name Tzield and is from ProventionBio and Sanofi, is given through intravenous infusion. Diabetic patients will now have easier access to insulin after the FDA approved an Eli Lilly biosimilar as interchangeable with the biologic drug , Bloomberg News notes. Rezvoglar,

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XTalks

OCTOBER 22, 2021

Boehringer Ingelheim’s Cyltezo has become the second interchangeable biosimilar approved by the FDA, and the first approved interchangeable monoclonal antibody. In July 2021, the agency approved the first interchangeable biosimilar product, Semglee (insulin glargine-yfgn) for the treatment of diabetes.

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pharmaphorum

FEBRUARY 28, 2022

Biocon’s partnership with Mylan – which merged with Pfizer’s Upjohn to form Viatris in 2020 – dates back more than a decade and has generated a number of biosimilars including insulin analogues, antibodies and recombinant proteins.

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pharmaphorum

JANUARY 11, 2021

Cambridge-based Kymab is one of several rising stars on the UK biotech scene, with technology that uses transgenic mice to develop antibodies optimised for the human immune system. In August last year Kymab said KY10005 had met both primary endpoints in a phase 2 trial in moderate to severe atopic dermatitis, otherwise known as eczema.

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pharmaphorum

MARCH 21, 2022

Teplizumab is thought to work by binding to CD3, preventing the activation of T cells that attack and kill insulin-producing pancreatic beta cells in the autoimmune disease. In the latter, teplizumab wasn’t able to show an impact on insulin use or HbA1c, an indirect measure of glucose control over time.

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Pharmaceutical Technology

DECEMBER 22, 2022

The main focus is the antibody-drug conjugate (ADC ), Enhertu (trastuzumab deruxtecan), which had already achieved regulatory approval as a second-line therapy for metastatic or recurrent HER2-positive breast cancer, as well as HER2-positive gastric or gastroesophageal junction adenocarcinoma. Civica JAAQ Sanofi.

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pharmaphorum

NOVEMBER 21, 2022

The company argues that the cost is justified as Tzield (teplizumab) is the first drug that can delay the onset of type 1 diabetes, fending off the time when they become highly reliant on insulins and at risk of the serious complications that can accompany advanced T1D.

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pharmaphorum

JANUARY 10, 2023

The report also says late-stage rivals from Eli Lilly (donanemab) and possibly Roche (gantenerumab) may follow suit pending the results of ongoing trials; 7) Lenacapavir : Gilead Sciences’ first-in-class capsid inhibitor makes the grade for its potential to transform the treatment of HIV thanks to a twice-yearly dosing regimen.

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Pharmaceutical Technology

DECEMBER 27, 2022

Drug pricing was a hot-button topic, and William Newton found that while e-commerce chains could cut insulin prices , any major change won’t happen overnight. A few months later, the monkeypox outbreak showed the difficulty in accessing vaccines and antivirals despite a plan to stockpile them.

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XTalks

FEBRUARY 8, 2021

They include proteins, monoclonal antibodies and vaccines that are considered to be “ highly similar ” to biological products that have already been approved by the FDA. Significantly, insulin was deemed to be a biologic as of March 23, 2020, making it a reference product for the development of biosimilar versions.

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Pharmaceutical Technology

JANUARY 30, 2023

Numerous drug approval applications to the FDA failed in 2022, including oncology monoclonal antibodies (mAbs) such as Eli Lilly and Co’s (Indianapolis, IN, US) sintilimab, Y-mAbs Therapeutics Inc’s (New York, NY, US) omburtamab, and Coherus BioSciences’ (Redwood City, CA, US) toripalimab. The drug increases insulin synthesis and release.

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Pharmaceutical Technology

MAY 15, 2023

Adeno-associated virus vectors, alcohol dehydrogenase compositions, and antibody serum stabilisers are some of the accelerating innovation areas, where adoption has been steadily increasing. Among maturing innovation areas are anti-influenza antibody compositions and anti-interleukin-1, which are now well established in the industry.

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Drug Discovery World

MAY 25, 2023

Research has shown that metabolism + inflammation leads to insulin resistance in type 2 diabetes. However, she has identified FFA4, a G protein-coupled receptor (GCPR) with the therapeutic potential to improve insulin sensitivity in metabolic disorders. It was a lively meeting, with lots of discussion and opportunities for networking.

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XTalks

MAY 13, 2021

Its latest ad campaign, “Wake Up to the Possibilities” set to the backdrop of Simon Ravenhall’s song “You Are My Sunshine,” boasts about the possibilities of lowering blood sugar for type 2 diabetics through a trifecta of increasing insulin, decreasing glycogen breakdown in the liver and slowing digestion. Eli Lilly spent $14.7

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Roots Analysis

MARCH 21, 2022

There has been a significant increase in the number of biologics, specifically the new generation molecules, such as monoclonal antibodies, in the late-stage clinical studies ( phase II / phase III ). This can be attributed to their relatively more efficient and patient friendly mode of drug delivery. Our Social Media Platform. Web: [link].

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pharmaphorum

OCTOBER 9, 2022

Chowiria was previously chairman and CBO at Nektar 2011 when it was trying to build a business in respiratory therapeutics including a now-defunct inhaled formulation of insulin. PureTech also has discovery and preclinical-stage candidates in oncology, including anti-Galectin-9 and Delta-1 antibodies for solid tumours.

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The Pharma Data

AUGUST 3, 2021

Revenue growth was 12 percent when excluding effects of 2020 COVID-related stocking patterns, revenue from COVID-19 antibodies and recent business development. The trial compared tirzepatide to insulin glargine in adults with type 2 diabetes and increased cardiovascular risk. The company recognized worldwide revenue of $148.9

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Delveinsight

AUGUST 20, 2020

Generating insulin-producing pancreatic beta cells from stem cells to substitute those damaged by the immune system is a promising approach for diabetes treatment. The takeover will proffer J&J control of an anti-FcRn antibody, which completed a phase 2 trial in myasthenia gravis earlier this year.

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The Pharma Data

AUGUST 17, 2021

About JEMPERLI (dostarlimab-gxly) JEMPERLI is a programmed death receptor-1 (PD-1)-blocking antibody that binds to the PD-1 receptor and blocks its interaction with the PD-1 ligands PD-L1 and PD-L2. The collaboration has resulted in three monospecific antibody therapies that have progressed into the clinic. Immune-Mediated Pneumonitis.

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pharmaphorum

MARCH 7, 2022

The World Health Organization (WHO) announced the opening of a global biomanufacturing hub located in South Korea to provide training to low- and middle-income countries seeking to produce vaccines and other biologics, such as insulin and monoclonal antibodies. .

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Pharmaceutical Technology

JANUARY 10, 2023

Hailed as a breakthrough, Tzield’s approval marks the first of its kind to be introduced since the discovery of insulin, which won the 1923 Nobel Prize in the category of Physiology or Medicine. These therapies work by reprogramming the immune system, preventing it from attacking and eradicating insulin-producing cells in the pancreas.

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The Pharma Data

DECEMBER 31, 2020

Antibodies Respond Differently to Severe Versus Mild COVID-19. Researchers at Stanford Medicine found that COVID-19 antibodies preferentially target different parts of the SARS-CoV-2 virus in mild COVID-19 cases than they do in severe cases. People with severe COVID-19 have low proportions of antibodies that target the spike protein.

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The Pharma Data

NOVEMBER 2, 2020

2, 2020 — An experimental antibody drug that targets one of the body’s key metabolism regulators may help obese people lose weight — at least briefly. It would take much more research to prove the antibody is safe and effective, Ryan said. MONDAY, Nov. She was not involved in the study.

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The Pharma Data

FEBRUARY 23, 2022

The World Health Organization (WHO), the Republic of Korea and the WHO Academy today announced the establishment of a global biomanufacturing training hub that will serve all low- and middle-income countries wishing to produce biologicals, such as vaccines, insulin, monoclonal antibodies and cancer treatments.

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Delveinsight

JULY 21, 2021

The body produces antibodies to fight infections, but in the case of Autoimmune diseases, the antibodies start attacking the body’s cells, tissues, and organs. Type 1 Diabetes is a chronic condition in which the pancreas produces little or no insulin. It is also known as insulin-dependent diabetes. Diabetes Type 1.

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XTalks

AUGUST 17, 2020

Monoclonal antibodies : these are antibodies that are designed to bind to specific targets on cells. The design of the immune biologic puts these elements together on an antibody scaffold. With the Neo-STAT platform, “it’s like making a separate antibody molecule for each one of those. Immune system modulators (i.e.

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XTalks

APRIL 22, 2022

Generally, antibody-based therapeutics are one of the main types of drugs that are assessed using receptor occupancy assays as they bind to specific cell surface receptors through which they impact downstream intracellular signalling pathways. The antibodies are conjugated to fluorochromes for them to be detected.

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XTalks

OCTOBER 26, 2020

Autoantibody screening involves measuring levels of islet autoantibodies (iAb) that recognize antigens found in insulin-producing pancreatic beta cells. Provention is developing an investigational anti-CD3 monoclonal antibody called PRV-031 (teplizumab), which is designed to delay onset, or prevent T1D in at-risk individuals.

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XTalks

AUGUST 2, 2023

2) Darzalex (daratumumab) Darzalex is a targeted monoclonal antibody that slows or stops the progression of multiple myeloma (a blood cancer) by binding to the CD38 protein on multiple myeloma cells. The monoclonal antibody targets CD20, a protein found on the surface of B lymphocytes (B cells). billion in 2022, a 32.44

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Camargo

NOVEMBER 29, 2021

Monoclonal antibodies (mAbs). Allergenics. Somatic cells. Gene and cellular therapies. Recombinant therapeutic proteins. Growth factors. Fusion proteins. Interferons. Biologics change the manner of operation of natural biologic intracellular and cellular actions.

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XTalks

SEPTEMBER 17, 2020

Acromegaly Surrogate Endpoint: Serum growth hormone and serum insulin-like growth factor 1 (IGF-1) are acceptable surrogate endpoints for acromegaly clinical trials involving somatostatin analogs such as octreotide, lanreotide and pasireotide. Also known as Berardinelli-Seip syndrome, there are four subtypes of lipodystrophy.

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Drug Discovery World

SEPTEMBER 6, 2022

CellTrans is currently awaiting an FDA decision for its cell therapy Lantidra, a treatment for patients with brittle type 1 diabetes mellitus whose symptoms cannot be well managed despite insulin therapy.

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