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Guide to using AAV vectors in gene therapy

Drug Discovery World

The event aimed to help the audience understand the AAV workflow, from upstream methods for AAV production and validation to downstream analysis of the packaged product for enhanced therapeutic development. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

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Guide to using AAV vectors in gene therapy

Drug Discovery World

The event aimed to help the audience understand the AAV workflow, from upstream methods for AAV production and validation to downstream analysis of the packaged product for enhanced therapeutic development. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

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For bacteria, a small genome means some serious decluttering — even in the ribosome

Scienmag

Researchers from Skoltech, Lomonosov Moscow State University, and the Kharkevich Institute for Information Transmission Problems have studied the genomes of some 200 strains of bacteria to determine which proteins in the ribosome, part of the key cell machinery, can be safely lost and why.

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Antibiotic resistance may spread even more easily than expected

Scienmag

Credit: Jan Zrimec/Chalmers University of Technology Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans.

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Full evolutionary journey of hospital superbug mapped for the first time

Scienmag

Modern hospitals and antibiotic treatment alone did not create all the antibiotic resistant strains of bacteria we see today. Instead, selection pressures from before widespread use of antibiotics influenced some of them to develop, new research has discovered.

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WHO launches global network to detect and prevent infectious disease threats

The Pharma Data

Pathogen genomics analyzes the genetic code of viruses, bacteria and other disease-causing organisms to understand how infectious they are, how deadly they are, and how they spread. Diseases do not respect borders: a disease threat in one country is also a threat to others.

Genome 52
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Researchers develop technique to functionally identify and sequence soil bacteria one cell at a time

Scienmag

Credit: LIU Yang Researchers from the Single-Cell Center at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences have developed a technique to sort and sequence the genome of bacteria in soil one bacterial cell at a time, while also identifying what its function is in the soil environment. […]. (..)