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Key early steps in gene expression captured in real time by CSU researchers

Scienmag

Capturing how RNA polymerase enzymes kick off transcription On scales too small for our eyes to see, the business of life happens through the making of proteins, which impart to our cells both structure and function.

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How big data analytics can make personalised care a reality

Drug Discovery World

Johannes Goll, Global Head of Emmes’ Biomedical Data Science and Bioinformatics department, explains how big data analytics can deliver improved therapies and bring clinical research one step close to realising the potential of personalised care. Figure 2: Advanced data visualisation examples for transcriptomics data.

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Democratising proteomics for cancer and beyond

Drug Discovery World

For instance, Mallick says he believes “80% of pontine gliomas have mutations in histone H3,” which in turn has a consequence on the “downstream chromatin landscape,” – a structure of DNA, RNA, histones and proteins which house the eukaryotic genome and in which mutations can lead to the development of cancers. “We BMC Bioinformatics.

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Synthetic biology tools advancing and accelerating drug discovery efforts

Drug Discovery World

Gene-to-antibody production begins with scientists entering antibody sequences as starting material, after which bioinformatics tools filter out potentially non-viable sequences. It’s now possible to programme cell-free systems to make RNA and proteins that interact with each other,” Dr Laohakunakorn continues.

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